Clinical trials: Adrenocortical Adenoma
Prevalence, Adrenal Incidentaloma
The Prevalence and Characteristics of Adrenal Incidentaloma
To investige the prevalence, characteristics and prognosis of adrenal incidentalomas in Chinese adults.
- Trial name
- NCT04682938
- Where
- China
- Volunteers
- 25,356 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Insulinoma; Pancreas, MEN1
Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions
The goal of this observational study is to evaluate the long-term clinical effectiveness of EUS-RFA and quality of life in patients with pancreatic or adrenal tumors recieving EUS-RFA.
- Conditions
- Insulinoma; Pancreas, MEN1, NETs, Radiofrequency Ablation
- Trial name
- EURAGIL (NCT07272187)
- Testing
- observational study
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Herlev Hospital
Primary Aldosteronism, Secondary Hypertension
PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA).
- Conditions
- Primary Aldosteronism, Secondary Hypertension, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT07027254
- Testing
- 68Ga-pentixafor PET/CT
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Metastatic Malignant Solid Neoplasm, Metastatic Melanoma
Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
This phase I trial studies the side effects and best dose of modified immune cells (IL13Ralpha2 CAR T cells) after a chemotherapy conditioning regimen for the treatment of patients with stage IIIC or IV melanoma or solid tumors…
- Conditions
- Metastatic Malignant Solid Neoplasm, Metastatic Melanoma, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8, Pathologic Stage IV Cutaneous Melanoma AJCC v8
- Trial name
- NCT04119024
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Anusha Kalbasi
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital
Primary Aldosteronism
Subtyping Primary Aldosteronism With Para-chloro-2-[18F]Fluoroethyl-etomidate
The goal of this clinical trial is to investigate the uptake characteristics of [18F]CETO in adrenal tissue in patients with two different subtypes of primary aldosteronism.
- Trial name
- SPACE (NCT06616142)
- Testing
- [18F]CETO tracer, Dexamethasone oral, Adrenal vein sampling
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Advanced Solid Tumors (Part A/B/C/D), Non-small Cell Lung Cancer (Part E)
A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549
This dose-escalation study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of IPI-549 monotherapy and IPI-549 in combination with nivolumab in subjects with advanced solid tumors.
- Conditions
- Advanced Solid Tumors (Part A/B/C/D), Non-small Cell Lung Cancer (Part E), Melanoma (Part E), Squamous Cell Cancer of the Head and Neck (Part E)
- Trial name
- NCT02637531
- Testing
- IPI-549 (eganelisib), Nivolumab
- Where
- 11 sites in United States
- Volunteers
- 219 people
- Sponsor
- Infinity Pharmaceuticals, Inc.
Pheochromocytoma, Non-Secretory Adrenal Adenoma
Intraoperative Hemodynamic Instability During Unilateral Adrenalectomy for Pheochromocytoma
Pheochromocytomas are tumors of the adrenal gland that develop from cells producing adrenaline and noradrenaline. Consequently, intraoperative blood pressure variations (hypertensive and hypotensive episodes) are characteristic…
- Trial name
- HEMODADRE (NCT06062082)
- Testing
- adrenalectomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
Pituitary Neoplasm, Pituitary Adenoma
Rhinological Outcomes in Endonasal Pituitary Surgery
This is a prospective, multi-center observational study designed to address patient-reported nasal outcomes in adults undergoing endoscopic and microscopic surgical removal of pituitary tumors.
- Conditions
- Pituitary Neoplasm, Pituitary Adenoma, Prolactinoma, Cushings Disease
- Trial name
- NCT01504399
- Where
- 4 sites in United States
- Volunteers
- 235 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Adrenal Incidentaloma
Natural History of NFAI: 10 Year Follow-up Results
The data on long term natural history of benign nonfunctioning adrenal tumors (NFATs) are lacking. The aim is to identify clinical characteristics associated with tumor growth and progression to mild autonomous cortisol excess…
- Trial name
- NCT04616703
- Testing
- CT imaging
- Where
- Slovenia
- Volunteers
- 65 people
- Sponsor
- University Medical Centre Ljubljana
Primary Hyperaldosteronism, Primary Hyperaldosteronism Due to Adrenal Adenoma
Radiofrequency Endoscopic Ablation With Ultrasound Guidance: a Non-surgical Treatment for Aldosterone-producing Adenomas
High blood pressure (hypertension) causes strokes and heart attacks. While most patients need long-term treatment with pills, some have a cause which can be removed, curing the hypertension.
- Trial name
- FABULAS (NCT03405025)
- Testing
- Endoscopic ultrasound guided radiofrequency ablation, ultrasound
- Where
- 3 sites in United Kingdom
- Volunteers
- 28 people
- Sponsor
- University College, London
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism
Majority of patients with hypertension have primary hypertension (without an underlying cause). Secondary hypertension (due to an underlying disease) is important to recognize, as treatment can lead to cure of hypertension.
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- PA_PACES (NCT03174847)
- Testing
- Adrenalectomy, Mineralocorticoid Receptor Antagonists
- Where
- Singapore
- Volunteers
- 57 people
- Sponsor
- Changi General Hospital
Endocrine Disorders, Adiposity
Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models
The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary…
- Conditions
- Endocrine Disorders, Adiposity, Pituitary Adenoma, Cushing Syndrome
- Trial name
- NCT06326853
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Hyperaldosteronism
Adrenal Vein Sampling International Study (AVIS Study)
The AVIS Study is a retrospective multicenter international study that aims to answer a series of questions on the use and performance of adrenal venous catheterization (AVS) for the diagnosis of primary hyperaldosteronism…
- Trial name
- AVIS (NCT01234220)
- Where
- 20 sites in United States, Australia and 8 more
- Volunteers
- 2,604 people
- Sponsor
- University Hospital Padova
Adrenal Adenoma, Cushing Syndrome
A Prospective Cohort Study for Patients With Adrenal Diseases
The purpose of this study is to investigate the pathologic features, complications, and prognostic factors of functioning adrenal adenoma and suggest follow-up algorithms for adrenal incidentaloma.
- Conditions
- Adrenal Adenoma, Cushing Syndrome, Pheochromocytoma, Adrenal Incidentaloma
- Trial name
- NCT03474237
- Testing
- Hormone study and Imaging study
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Seoul National University Hospital
Subclinical Hypercortisolism, Cushing Syndrome
Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
Background: Adrenal tumors are a common kind of tumor. Some of these secrete extra cortisol into the body, which can lead to diabetes, obesity, and other diseases.
- Conditions
- Subclinical Hypercortisolism, Cushing Syndrome, Adrenal Neoplasm
- Trial name
- NCT02001051
- Testing
- Adrenalectomy, Observation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Adrenal Tumor, Adrenal Disease
Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy
The goal of this multicenter, observational, analytic, randomized clinical trial is to analyze the laparoscopic and robot-assisted method in the surgical treatment of patients with adrenal diseases.
- Conditions
- Adrenal Tumor, Adrenal Disease, Adrenal Mass, Adrenalectomy; Status
- Trial name
- NCT06050057
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Olomouc
Primary Aldosteronism, Aldosterone-Producing Adenoma
Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma
This is a prospective, single-center, single-arm study evaluating endoscopic ultrasound-guided ethanol ablation for left-sided aldosterone-producing adenoma.
- Trial name
- CREATE (NCT07700472)
- Testing
- Endoscopic Ultrasound-Guided Ethanol Ablation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chongqing Medical University
Cushing's Syndrome, Pituitary Adenoma
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Lentiginosis refers to groups of diseases marked by the presence of pigmented spots on the skin. These conditions are most commonly associated with multiple tumors and changes in hormone producing glands.
- Conditions
- Cushing's Syndrome, Pituitary Adenoma, Carney Complex, Primary Pigmented Nodular Adrenocortical Disease
- Trial name
- NCT00001452
- Testing
- oCRH
- Where
- United States
- Volunteers
- 1,387 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)