Clinical trials: Adult
Heart Defects, Congenital, Cardiovascular Disease Other
Congenital Heart Disease Physical Activity Lifestyle Study V.2
The Congenital Heart Disease Physical Activity Lifestyle Intervention Study (CHD-PALS) V.2 seeks to determine the efficacy of a lifestyle intervention program for adolescents and young adults (AYAs) with congenital heart disease…
- Trial name
- CHD-PALS V2 (NCT06003023)
- Testing
- Physical Activity Monitoring, Tailored Exercise Prescription, Healthy Lifestyle Education
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Jamie Jackson
Aging, Sensory Deficit
Walking Sensation Study
The primary objective of this new line of research is to test whether augmenting sensory information from the legs, using Walkasins sensory neuroprosthesis, can enhance performance of a complex walking task in older adults with…
- Trial name
- NCT06975423
- Testing
- Active lower-limb neuroprosthesis, Inactive lower-limb neuroprosthesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Non-Alcoholic Steatohepatitis
Safety and Tolerability Study of SHP626 in Overweight and Obese Adults
This study will investigate the safety and tolerability of daily dosing regimens of SHP626 in overweight and obese adults.
- Trial name
- NCT02287779
- Testing
- SHP626
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mirum Pharmaceuticals, Inc.
Insulin Resistance, Prediabetic State
Impact of Digital Therapeutic on Metabolic Parameters
The purpose of this prospective randomized controlled study is to evaluate the impact of a six-month digitally administered behavioral change program on body weight, glycemic control and other metabolic parameters in obese adults…
- Conditions
- Insulin Resistance, Prediabetic State, Diabetes Mellitus, Type 2, Obesity
- Trial name
- NCT04573296
- Testing
- Vitadio, Conventional high-intensity lifestyle intervention program
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Vitadio s.r.o.
Uncomplicated Urinary Tract Infection, Cystitis
Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis
The purpose of this study is to evaluate the safety and efficacy of oral omadacycline as compared to oral nitrofurantoin in the treatment of female adults with cystitis.
- Trial name
- NCT03425396
- Testing
- Omadacycline tablets, Nitrofurantoin capsules
- Where
- 23 sites in United States
- Volunteers
- 225 people
- Sponsor
- Paratek Pharmaceuticals Inc
Tardive Dyskinesia
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
The primary objective of this study is to evaluate the efficacy of NBI-1065890 compared with placebo for the treatment of tardive dyskinesia (TD) in adult participants.
- Trial name
- NCT07365462
- Testing
- NBI-1065890
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
Cardiovascular Risk Factor
Choline and Cardiometabolic Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT04764162
- Testing
- Choline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Needs for Rehabilitation, Adult Attachment Style
The Need for Rehabilitation and the Connection With Attachment Styles Among Patients With Gynaecological Cancer
The purpose of this study is to provide new knowledge about: Integration of rehabilitation in a highly specialized gynaecological department. Development and testing of an individually adapted rehabilitation process.
- Conditions
- Needs for Rehabilitation, Adult Attachment Style, Quality of Life., Depression
- Trial name
- NCT01638741
- Testing
- Rehabilitation goals of patients with gynaecological cancer.
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Kamila Adellund Holt
Gut Microbiota
To Investigate the Effect of Arabinogalactan on the Gut Microbiome in Adults
Dietary fiber is an important nutrient that supports gastrointestinal function, as well as the maintenance of blood glucose and cholesterol.
- Trial name
- NCT04351841
- Testing
- arabinogalactan, maltodextrin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biofortis, Merieux NutriSciences
Dialysis, Chronic Kidney Disease
Next Generation Advanced Insulin Delivery System in Adults With Diabetes and Advanced Renal Disease
The goal of this this randomized, clinical trial is to test an automated insulin delivery system (AID) in people with type 1 or type 2 diabetes who are on hemodialysis, peritoneal dialysis, or have advanced chronic kidney disease…
- Conditions
- Dialysis, Chronic Kidney Disease, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT06330194
- Testing
- 2nd Generation Automated Insulin Delivery (AID) system
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Steno Diabetes Center Copenhagen
Respiratory Tract Diseases, Respiratory Hypersensitivity
Effects Of Ciclesonide And Beclomethasone On Lens Opacification In Adult Subjects With Moderate To Severe Persistent Asthma
The primary objective is to demonstrate the non-inferiority of ciclesonide compared to beclomethasone-HFA in the occurrence of Class 1 lens event for nuclear (NO), cortical (C), or posterior subcapsular (P) lens opacification…
- Conditions
- Respiratory Tract Diseases, Respiratory Hypersensitivity, Asthma
- Trial name
- NCT00254956
- Testing
- ciclesonide (XRP1526)
- Where
- France
- Volunteers
- 1,568 people
- Sponsor
- Sanofi
Chronic Insomnia Disorder
Online Tai Chi Versus Digital CBT-I for Chronic Insomnia
This multicenter randomized controlled trial will compare online Tai Chi (OTC) with digital cognitive behavioral therapy for insomnia (dCBT-I) in adults with chronic insomnia disorder.
- Trial name
- NCT07853651
- Testing
- Online Tai Chi, Digital Cognitive Behavioral Therapy for Insomnia
- Where
- China
- Volunteers
- 172 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Vaping Cessation
Mindful Breaths: Mindfulness for Young Adult Vaping
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary efficacy of mindfulness-based interventions (MBI) as a vaping cessation intervention in young adults aged 18-29 who vape nicotine at…
- Trial name
- NCT06626529
- Testing
- Guided mindfulness meditation, Scenery video
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Tulane University
Postural Assessment, Body Posture
Validity and Reliability of the DeepClinic Posture Assessment Application
Posture assessment is widely used in sports medicine, physiotherapy, and rehabilitation to identify body alignment problems and support clinical decision-making.
- Conditions
- Postural Assessment, Body Posture, Postural Alignment
- Trial name
- NCT07702331
- Testing
- DeepClinic Posture Assessment, APECS Posture Analysis System
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul Gelisim University
H1N1 Flu
Study of the Safety and Immunogenicity of H1N1 Vaccine
The Purpose Of This Study Is To Assess The Safety, Immunogenicity, And Tolerability Of A H1N1 Vaccine In Healthy Adults
- Trial name
- NCT01177202
- Testing
- HAC1 Vaccine
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fraunhofer, Center for Molecular Biotechnology
Advanced Cancer
A Phase I Trial of DM-CHOC-PEN in Adolescent and Young Adult (AYA) Subjects With Advanced Cancers
4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) is a polychlorinated pyridyl cholesterol carbonate that is lipophilic, electrically neural, crosses the blood brain barrier (BBB), ability to localize in intracranial…
- Trial name
- NCT02889445
- Testing
- 4-Demethyl-4-cholesteryloxycarbonylpenclomedine
- Where
- United States
- Sponsor
- DEKK-TEC, Inc.
Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma
A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
The goal of this clinical trial is to learn whether the Ad5.F35-hGCC-PADRE vaccine is safe and can stimulate an immune response against gastrointestinal (GI) cancers in patients with pancreatic, colorectal, esophageal, gastric…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma, Gastric Adenocarcinoma, Clinical Stage II Gastric Cancer AJCC v8
- Trial name
- NCT04111172
- Testing
- Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Leukemia, Lymphoma
Total-Body Irradiation, Tacrolimus, and Mycophenolate Mofetil Plus Bone Marrow Transplantation in Treating Patients With Hematologic Cancers
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Bone marrow transplantation may be able to replace immune cells that have been destroyed by radiation therapy used to kill tumor cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00003572
- Testing
- peripheral blood lymphocyte therapy, mycophenolate mofetil, tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Eldery People, Cognitive Decline
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
The purpose of this placebo-controlled trial is to compare the effects of 24-weeks supplementation with LPC-DHA and TAG-DHA on cerebrospinal fluid and blood DHA levels, as well as biomarkers of central neurodegenerative and…
- Conditions
- Eldery People, Cognitive Decline, Memory Decline, DHA CNS Delivery
- Trial name
- NCT06933095
- Testing
- LPC-EPA+DHA capsules containing omega-3 fatty acids EPA and DHA esterified to lysophosphatidylcholine (LPC-EPA+DHA)(Trade name: Lysoveta)
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Cincinnati
Healthy Male Volunteers
A Single Intravenous Dose Study of E3112 in Japanese Healthy Adult Male Subjects
The study (E3112/CP1) is a single-center, randomized, double-blind, placebo-controlled, single intravenous ascending dose study conducted in Japanese healthy adult males to evaluate the pharmacokinetics (PK), safety, and…
- Trial name
- NCT03014895
- Testing
- E3112
- Where
- Japan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- EA Pharma Co., Ltd.
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