Clinical trials: Adult
Post-Operative Cognitive Decline in Older Adults
Study To Analyze Memory/Thinking Problems In Older Adults After Surgery
The purpose of the study is to examine specific neuroimaging predictors of memory and executive decline in older adults at various stages after total knee replacement surgery.
- Trial name
- POCD (NCT01786577)
- Testing
- Magnetic Resonance Imaging, Cognitive assessment testing
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Florida
Gastrointestinal Microbiome, Nutrition, Healthy
The Effects of a Novel Nutritional Product on Nutrient Gaps and Gut Health in Active Adults
This study is a randomized, double-blind, placebo-controlled study of N=20 active men and women. This study to assess the effect of a novel dietary supplement on improving nutrient gaps and the gut microbiome.
- Conditions
- Gastrointestinal Microbiome, Nutrition, Healthy, Exercise
- Trial name
- NCT06521424
- Testing
- AG1 - Nutritional Supplement
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Athletic Greens International
Infraorbital Hollowing
Study to Assess Effectiveness and Adverse Events of JUVEDERM VOLBELLA With Lidocaine Injection in Correcting Infraorbital Hollowing in Chinese Adult Participants
Aged appearance is often caused by an infraorbital hollowing, which is characterized as a sunken appearance of the eye that results in the casting of a dark shadow over the nasal lower eyelid, giving a fatigued appearance.
- Trial name
- NCT05088980
- Testing
- VOLBELLA with Lidocaine
- Where
- 7 sites in China
- Volunteers
- 160 people
- Sponsor
- Allergan
Diabetic Peripheral Neuropathy
A Study Of The Analgesic (Pain-Relief) Effects Of Tanezumab In Adult Patients With Diabetic Peripheral Neuropathy
The purpose of this study is to determine the effectiveness and safety of the investigational drug, tanezumab, in adult patients with painful diabetic peripheral neuropathy.
- Trial name
- NCT01087203
- Testing
- Tanezumab
- Where
- 48 sites in United States
- Volunteers
- 73 people
- Sponsor
- Pfizer
Mesothelioma, BAP1 Loss of Function
Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma
This is a Phase 2, multicenter, open-label, 2-part, single-arm, 2-stage study of tazemetostat 800 mg two times a day (BID) administered orally.
- Trial name
- NCT02860286
- Testing
- Tazemetostat
- Where
- 16 sites in United States, France and 1 more
- Volunteers
- 74 people
- Sponsor
- Epizyme, Inc.
Adenoid Cystic Carcinoma, Colorectal Cancer
Study of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
Phase 1 study to evaluate safety, tolerability and anti-tumor activity of RGT-61159 in patients with ACC or CRC
- Trial name
- NCT06462183
- Testing
- RGT-61159, lenvatinib
- Where
- 9 sites in United States, Canada
- Volunteers
- 105 people
- Sponsor
- Rgenta Therapeutics Inc
Obesity
Physical Activity, Meal Composition, and RMR Among Children Adolescent and Adults
Resting metabolic rate (RMR) is the amount of energy the body uses at rest, and accounts for 60%-70% of daily energy expenditure.
- Trial name
- NCT04284683
- Testing
- DRINK - Water, Protein, Fat, Carbohydrate
- Where
- 2 sites in Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Insomnia, Adults
A Theory-based Sleep Hygiene Education for Insomnia Patients
Insomnia is a prevalent sleep disorder associated with substantial negative health consequences, including fatigue, irritability, and impaired daytime functioning.
- Trial name
- NCT07559305
- Testing
- Sleep Hygiene Education
- Where
- Hong Kong
- Volunteers
- 11 people
- Sponsor
- The Hong Kong Polytechnic University
Depressive Disorder, Major
Efficacy and Safety Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
The purpose of this study is to evaluate the efficacy of vortioxetine, once daily (QD), compared with placebo in adults with major depressive disorder.
- Trial name
- NCT01163266
- Testing
- Vortioxetine
- Where
- 39 sites in United States
- Volunteers
- 462 people
- Sponsor
- Takeda
Human Immunodeficiency Virus 1 Positive, Stage I Adult Hodgkin Lymphoma
HIV-Resistant Gene Modified Stem Cells and Chemotherapy in Treating Patients With Lymphoma With HIV Infection
This pilot phase I trial studies the side effects and best dose of human immunodeficiency virus (HIV)-resistant gene modified stem cells in treating HIV-positive patients who are undergoing first-line treatment for Hodgkin or…
- Conditions
- Human Immunodeficiency Virus 1 Positive, Stage I Adult Hodgkin Lymphoma, Stage I Adult Non-Hodgkin Lymphoma, Stage II Adult Hodgkin Lymphoma
- Trial name
- NCT02343666
- Testing
- C46/CCR5/P140K Lentiviral Vector-transduced Autologous HSPCs, Carmustine, Filgrastim
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Chronic Hepatitis B
Study to Evaluate the Safety, Tolerability, and Antiviral Activity of Selgantolimod (Formerly GS-9688) in Viremic Adult Participants With Chronic Hepatitis B (CHB) Who Are Not Currently on Treatment
The primary objectives of this study are to evaluate the safety and tolerability of multiple oral doses of selgantolimod and to evaluate the antiviral activity of selgantolimod in adult participants with chronic hepatitis B (CHB)…
- Trial name
- NCT03615066
- Testing
- Selgantolimod, TAF
- Where
- 10 sites in Canada, South Korea and 1 more
- Volunteers
- 67 people
- Sponsor
- Gilead Sciences
Abdominal Pain, Abdominal Cramps
A Study on Intestinal Gas Symptoms to Evaluate the Effects of Gas Defense in Otherwise Healthy Adult
This is a randomized, double-blind, placebo-controlled trial to determine the safety and efficacy of Digestive Advantage™ Gas Defense formula, a probiotic dietary supplement.
- Conditions
- Abdominal Pain, Abdominal Cramps, Flatulence
- Trial name
- NCT00881322
- Testing
- BC-130 (Gas Defense)
- Where
- 2 sites in United States, Dominican Republic
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Miami Research Associates
Malaria
Trial to Evaluate L9LS in Healthy Adults
Background: Malaria is a parasitic disease carried by mosquitoes in tropical areas. There is no vaccine to prevent malaria infection. If not treated right away, it can become serious or deadly.
- Trial name
- VRC 614 (NCT05019729)
- Testing
- VRC-MALMAB0114-00-AB, Plasmodium falciparum (P. falciparum) sporozoite challenge
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Iron Deficiency Anemia
Efficacious Iron for Iron Deficiency Anemia in Adults Aged ≥18 Years
Iron deficiency anemia (IDA) is a widespread condition affecting many people globally. Despite the many cases of IDA, there are few studies that compare the effectiveness of different types of iron supplements with a greater…
- Trial name
- NCT06303531
- Testing
- Ferrous Fumarate, Polysaccharide Iron, Ferrous Ascorbate
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Dr. Anil K. Gupta Medicine Professional Corporation
Cardiovascular Diseases, Stress, Psychological
Adaptive Internet-based Stress Management Among Adults With a Cardiovascular Disease: A Pilot Sequential Multiple Assignment Randomized Trial (SMART) Design
Internet-based stress management programs adapted to patients' needs Stress is inevitable, and it has many negative consequences on the health of everybody, but particularly on the health of patients with a cardiovascular disease…
- Trial name
- NCT03267953
- Testing
- My Health CheckUp Online Stress Management Program, Lay telephone coaching, Motivational interviewing (telephone)
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- St. Mary's Research Center, Canada
Hypertrophic Scar
A Study to Evaluate the Effectiveness and Safety of RXI 109 on the Outcome of Scar Revision Surgery in Healthy Adults
The purpose of this study is to determine the effectiveness of RXI-109 in reducing the recurrence of hypertrophic scar formation following elective revision of a pre-existing hypertrophic abdominal scar.
- Trial name
- NCT02030275
- Testing
- RXI-109
- Where
- 5 sites in United States, Honduras
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- RXi Pharmaceuticals, Corp.
Healthy
Effect of Passive Heat Therapy on Metabolism
The goal of this prospective interventional study is to examine if repeated brief hot stimuli affects glucose metabolism and substrate oxidation in young non-obese adults.
- Trial name
- NCT06147557
- Testing
- Heat therapy
- Where
- Lithuania
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Sexually Transmitted Diseases
Safety and Efficacy of GSK Neisseria Gonorrhoeae GMMA (NgG) Investigational Vaccine When Administered to Healthy Adults 18 to 50 Years of Age
The aim of this first time in human proof of concept (FTiH-PoC) study was to evaluate safety and reactogenicity, to demonstrate efficacy and to explore immunogenicity of GlaxoSmithKline's (GSK) Neisseria gonorrhoeae generalized…
- Trial name
- NCT05630859
- Testing
- NgG 12.5 µg investigational vaccine, NgG 25 µg investigational vaccine, NgG 50 µg investigational vaccine
- Where
- 23 sites in United States, Brazil and 6 more
- Volunteers
- 1,009 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Opioid Use Disorder, Opioid Misuse
Natural Language Processing for Screening Opioid Misuse
This is a clinical study to implement and evaluate a hospital-wide, operational intervention for a real-time natural language processing (NLP)-driven clinical decision support (CDS) tool, called Substance Misuse Algorithm for…
- Trial name
- NCT05745480
- Testing
- Opioid Misuse Screening with an Addiction Consult Service
- Where
- United States
- Volunteers
- 47,502 people
- Sponsor
- University of Wisconsin, Madison
Metabolic Health, Cardio Respiratory Fitness
HIIT, Cardiorespiratory Fitness, and Metabolic Health in Healthy Young Adults
The purpose of this study was to investigate the effects of a high-intensity interval training (HIIT) intervention on cardiorespiratory fitness (CRF) and cardiometabolic health in active male university students.
- Trial name
- NCT07719296
- Testing
- High-intensity interval training (HIIT) program
- Where
- Tunisia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- High Institute of Sports and Physical Education of Kef
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