Clinical trials: Adult
Epilepsy, Partial-onset Seizures
A Trial to Evaluate the Long Term Safety and Tolerability of Lacosamide Taken as Monotherapy in Adults With Partial-onset Seizures
This study is to evaluate the long-term safety and tolerability of Lacosamide (LCM) 200 mg/day to LCM 600 mg/day taken in monotherapy in Japanese subjects who currently have partial-onset seizures with or without secondary…
- Trial name
- NCT02124564
- Testing
- Lacosamide
- Where
- 11 sites in Japan
- Volunteers
- 19 people
- Sponsor
- UCB Japan Co. Ltd.
Alcohol Use Disorder
Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD)
This study is a randomized controlled trial of oral semaglutide among treatment-seeking individuals with AUD. The investigators will randomly assign 50 participants to receive semaglutide (titrated to 7 milligrams (mg) per day)…
- Trial name
- NCT05892432
- Testing
- Semaglutide 3 MG [Rybelsus], Semaglutide 7 MG [Rybelsus]
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Muscle Strength
Effects of Vibrations on the Biceps Brachii Muscle and Grip Strength
It has been suggested that applying acute vibration exercises enhances muscle force, like several weeks of resistance training. The present study investigated the effects of local vibration with two different frequencies on…
- Trial name
- NCT05523232
- Testing
- Vibration training with 42 Hz, Vibration training with 63 Hz
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Saud University
Post-COVID-19 Syndrome, Post-COVID Syndrome
Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome
The aim of this study is to evaluate the efficiency and safety of immunoadsorption for the treatment of post-COVID syndrome (PCS).
- Conditions
- Post-COVID-19 Syndrome, Post-COVID Syndrome, Post COVID-19 Condition
- Trial name
- IAMPOCO (NCT05841498)
- Testing
- Immunoadsorption
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Medical Center Mainz
Earthquake
The Effect of Psychoeducation on Cognitive Emotion Regulation and Negative Emotional Symptoms
This research was planned to determine the effect of cognitive behavioral approach-based psychoeducation on the cognitive emotion regulation strategies and negative emotional symptom levels of emerging adults who experienced an…
- Trial name
- NCT06045637
- Testing
- Group included in a psychoeducational program based on the cognitive behavioral approach (experiment)
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University
Diabetes Mellitus, Type 1
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
The purpose of this study is to find out if baricitinib can delay the onset of clinical type 1 diabetes (T1D) in people who are at high risk to develop T1D. Participation in the study will last up to approximately 5 years.
- Trial name
- BARICADE-DELAY (NCT07222137)
- Testing
- Baricitinib
- Where
- 112 sites in United States, Australia and 17 more
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus
Impact of Optimized Titration and Delivery of Bedtime Insulin on Prevention of Nocturnal Hypoglycemia
The purpose of this study is to determine whether or not bedtime snacks are necessary to prevent overnight low blood glucose reactions (nocturnal hypoglycemia) in adults with type 1 diabetes who are using intensive insulin…
- Trial name
- NCT00475345
- Testing
- Bedtime snacks
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- McGill University
Fracture
Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department
The goal of this clinical trial is to learn if buprenorphine can treat pain in older adults who have broken bones. The main questions it aims to answer are: Is buprenorphine as effective as opioids to treat pain? Are there less…
- Trial name
- NCT07430345
- Testing
- Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- The Cooper Health System
Respiratory Syncytial Virus Infections
RV568 - Viral Challenge With RSV
RV568 is being developed for the treatment of diseases such as asthma, COPD and allergic rhinitis (e.g. hayfever). The main aim of this study is to investigate whether RV568 is effective in reducing the inflammation caused by…
- Trial name
- NCT01230645
- Testing
- RV568
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Respivert Ltd
Advanced Solid Tumors
Study of SIM0508 Alone and in Combination in Patients With Advanced Solid Tumors
This is a multicenter, open-label, first-in-human study to evaluate the safety,efficacy, and PK/PD characteristics of SIM0508 as a single agent and in combination with olaparib in participants with locally advanced/metastatic…
- Trial name
- NCT06686745
- Testing
- SIM0508 Tablets, SIM0508 in combination with olaparib
- Where
- 2 sites in China
- Volunteers
- 130 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Frailty Syndrome, Geriatric Health
Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Geriatric Health, Respiratory Muscle Weakness, Age-Related Frailty
- Trial name
- NCT07556445
- Testing
- Inspiratory Muscle Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Brain Metastases, Adult
A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases
This is a research study to determine if performing stereotactic radiosurgery (SRS) prior to surgical resection of the brain metastasis (tumor) will improve local control, in other words, increase the possibility of total removal…
- Trial name
- NCT05341739
- Testing
- Pre-operative Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Wellness Program, Cancer Survivorship
Brief Meaning-making for Young Adult Cancer Survivors
The goal of this feasibility study is to learn if a brief meaning-making wellness intervention based on Viktor Frankl's Existential Psychology works to improve fatigue levels in Young Adult Cancer Survivors (YACS) who have…
- Conditions
- Wellness Program, Cancer Survivorship, Adolescent and Young Adult Cancer Survivors
- Trial name
- NCT07836075
- Testing
- Meaning-making
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Heart Failure
Values-Affirmation + Education Intervention Targeting Medication Adherence in Older Adults With Heart Failure
The goals of this study are to determine the (1) feasibility and (2) acceptability of the study procedures through a pilot randomized controlled trial of a values affirmation intervention targeting medication adherence in adults…
- Trial name
- NCT05575375
- Testing
- Values Affirmation + Usual Care, Usual Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- The Miriam Hospital
Latent Autoimmune Diabetes in Adults (LADA)
Hybrid Closed-Loop System in LADA Patients: A Randomized Trial
Based on the difficulties in blood glucose control among the Latent Autoimmune Diabetes in Adults (LADA) population and the deficiencies of previous studies, this research aims to conduct a clinical comparative study.
- Trial name
- NCT06941675
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanxi Bethune Hospital
Healthy
A Study to Compare the Relative Bioavailability of Moexipril HCl/Hydrochlorothiazide in Healthy Adult Volunteers Under Fasting Conditions
The purpose of this study was to evaluate the relative bioavailability of Paddock Laboratories, Inc.'s test formulation of Moexipril/ Hydrochlorothiazide 15mg/25mg tablets with a reference formulation Uniretic®(Moexipril/…
- Trial name
- NCT00990301
- Testing
- Moexipril HCl/ Hydrochlorothiazide 15mg/ 25mg Tablet, Paddock Laboratories, Inc., Uniretic® 15mg/25mg Tablets
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Paddock Laboratories, Inc.
Respiratory Syncytial Virus
A Study to Assess EDP-938 for the Treatment of Acute Upper Respiratory Tract Infection With Respiratory Syncytial Virus in Adult Subjects
This was a randomized, double-blind, placebo-controlled, multicentre, phase 2 study to evaluate the efficacy, safety and tolerability of orally administered EDP-938 in adults with RSV infection.
- Trial name
- RSVP (NCT04196101)
- Testing
- EDP-938
- Where
- 29 sites in United States, Argentina and 5 more
- Volunteers
- 82 people
- Sponsor
- Enanta Pharmaceuticals, Inc
Major Surgery in Adult Patients
Central Temperature Monitoring by Zero-heath-flux a Non-invasive Technic Compared to Two Invasive Technic During Surgery
Core temperature monitoring is mandatory during major surgery. The accurate techniques currently used are invasive, such as artery catheter and oesophagal probe.
- Trial name
- TEMP CORE BLOC (NCT02869828)
- Testing
- Monitoring by arterial catheter and Spot-on, Monitoring by oesophagal probe and Spot-on
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
Asthma Intermittent, Uncontrolled
Feasibility of an Asthma Online Social Intervention
The goal of this observational study is to test the feasibility and acceptability of an online intervention for people with troublesome asthma in primary care, involving a consultation with a primary care clinician to introduce…
- Trial name
- NCT05829265
- Testing
- A digital social intervention by primary care clinicians.
- Where
- United Kingdom
- Volunteers
- 526 people
- Sponsor
- Queen Mary University of London
B-cell Acute Lymphoblastic Leukemia
Inaticabtagene Autoleucel Injection Treatment for Adult Relapsed or Refractory Acute Lymphocytic Leukemia
This clinical trial is a non-interventional, observational, multicenter, post-marketing real-world study to evaluate the efficacy and safety of Inaticabtagene Autoleucel Injection in Chinese adult patients with relapsed or…
- Trial name
- NCT06450067
- Where
- 10 sites in China
- Volunteers
- 200 people
- Sponsor
- Juventas Cell Therapy Ltd.
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