Clinical trials: Adult
HIV, Cardiovascular Diseases
Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults
People with HIV are at risk for cardiovascular disease (CVD). This study evaluated the use of pitavastatin to reduce the risk of CVD in adults with HIV on antiretroviral therapy (ART).
- Trial name
- REPRIEVE (NCT02344290)
- Testing
- Pitavastatin
- Where
- 137 sites in United States, Botswana and 11 more
- Volunteers
- 7,769 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Adult Asthma Surveillance and Intervention in a Managed Care Setting
1. To determine if there are gender differences in asthma prevalence, severity, treatment, and health care utilization within patient populations in Kaiser Permanente Northwest and Colorado Regions. 2.
- Trial name
- NCT00147810
- Testing
- Telephone outreach to enhance asthma care
- Where
- United States
- Volunteers
- 6,948 people
- Sponsor
- Kaiser Permanente
Tetralogy of Fallot
Exercise Training in Adults With Corrected Tetralogy of Fallot
In this controlled trial, patients with tetralogy of Fallot will be randomized to either interval training, continuous training, or usual care groups.
- Trial name
- NCT02643810
- Testing
- Exercise training
- Where
- Slovenia
- Volunteers
- 27 people
- Sponsor
- University Medical Centre Ljubljana
Chronic Rhinosinusitis With Nasal Polyps
A Study in Male and Female Adult Participants With Chronic Rhinosinusitis With Nasal Polyps In the Greater Gulf Region
Primary Objective: To describe the clinical characteristics of participants with chronic rhinosinusitis with nasal polyps (CRSwNP) in terms of disease severity, Type 2 inflammation-related comorbidities (such as asthma and…
- Trial name
- NCT05649813
- Where
- Kuwait
- Volunteers
- 148 people
- Sponsor
- Sanofi
Episodic Migraine, Chronic Migraine
A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults
A migraine is a headache with severe throbbing pain or a pulsating sensation, usually on one side of the head. It is often accompanied by feeling or being sick and a sensitivity to bright lights and sound.
- Trial name
- MERANTI (NCT06625060)
- Testing
- Corabotase, Corabotase dose A, Corabotase dose B
- Where
- 162 sites in United States, Australia and 12 more
- Volunteers
- 670 people
- Sponsor
- Ipsen
Drug Hypersensitivity
A Study to Assess the Hypersensitivity to TAK-880 Compared to Gammagard S/D in Blood of Children, Teenagers and Adults
The aim of this study is to find out whether TAK-880 creates hypersensitivity reactions compared to Gammagard S/D by testing blood taken from participants who have a higher risk of becoming hypersensitive to immunoglobulin…
- Trial name
- NCT05269082
- Testing
- No intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Takeda
Unspecified Adult Solid Tumor, Protocol Specific
Monoclonal Antibody Plus Cyclophosphamide in Treating Patients With Metastatic Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00002482
- Testing
- antibody therapy, biological therapy, muromonab-CD3
- Where
- United States
- Sponsor
- St. Vincent Medical Center - Los Angeles
Cognitive Decline, Nutrition, Healthy
Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults
This study will test whether consuming blueberry powder 20g/d for 24 weeks can improve memory and other cognitive function and alter serum biomarkers of brain injury among older adults.
- Conditions
- Cognitive Decline, Nutrition, Healthy, Brain Injuries
- Trial name
- NCT05764824
- Testing
- Blueberry powder, Controlled and matched powder
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Psoriasis
Study of Subcutaneous Risankizumab Injection Compared to Oral Apremilast Tablets to Assess Change in Disease Activity And Adverse Events in Adult Participants With Moderate Plaque Psoriasis Who Are Candidates for Systemic Therapy
Psoriasis (PsO) is a chronic disease characterized by marked inflammation of the skin that results in thick, red, scaly plaques.
- Trial name
- NCT04908475
- Testing
- Risankizumab, Apremilast
- Where
- 54 sites in United States, Canada and 3 more
- Volunteers
- 352 people
- Sponsor
- AbbVie
Obesity, Time Restricted Feeding
Time Restricted Feeding on Weight Loss and Cardio-protection (TREATY Trial)
Time restricted feeding (TRF) is a novel type of intermittent calorie restriction diet that involves eating a daily period of 8 hours or less.
- Conditions
- Obesity, Time Restricted Feeding, Weight Loss, Calorie Restriction
- Trial name
- TREATY (NCT03745612)
- Testing
- Time restricted feeding, Continuous Energy Restriction
- Where
- China
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Metastatic Melanoma
Patient Characteristics, Treatment Patterns, and Healthcare Resource Utilization of Metastatic Melanoma Patients
This was a retrospective, non-interventional, registry study based on secondary electronic medical record (EMR) data collected in Helsinki and Uusimaa hospital district (HUS data lake), hospital district of Southwest Finland…
- Trial name
- NCT06369428
- Where
- Switzerland
- Volunteers
- 1,795 people
- Sponsor
- Novartis
Leukemia
High-Intensity, Brief-Duration Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002865
- Testing
- filgrastim, cyclophosphamide, cytarabine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Hemiplegic Cerebral Palsy
Spinal Cord Associative Plasticity in Cerebral Palsy
Associative plasticity has been used to promote functional recovery from conditions affecting movement. The long term goal of this project is to use electrical stimulation techniques to improve arm and hand function.
- Trial name
- SCAP-CP (NCT07607665)
- Testing
- Paired brain and nerve stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Columbia University
Cervical Dystonia
Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS)
Phase 3, open-label, multi-center trial to evaluate the long-term safety, efficacy, and immunogenicity of up to four continuous treatment cycles of daxibotulinumtoxinA (DAXI) for injection.
- Trial name
- ASPEN-OLS (NCT03617367)
- Testing
- daxibotulinumtoxinA for injection
- Where
- 65 sites in United States, Austria and 7 more
- Volunteers
- 357 people
- Sponsor
- Revance Therapeutics, Inc.
Chronic Spontaneous Urticaria
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HS-10561 Capsule in Healthy Chinese Adults and Patients With Chronic Spontaneous Urticaria.
This is a randomized, double-blind, placebo-controlled phase 1/2 clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of HS-10561 capsule in healthy Chinese adults and patients with…
- Trial name
- NCT06864507
- Testing
- HS-10561
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
HIV Infections
Evaluating the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibodies in Healthy Participants
Part A: The purpose of this part is to study how the body's immune system reacts to a lab-made HIV-1 monoclonal antibody against HIV antigen when given in different doses.
- Trial name
- HVTN143 (NCT05959707)
- Testing
- VRC01.23LS, PGT121.414.LS, PGDM1400LS
- Where
- 8 sites in South Africa
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- HIV Vaccine Trials Network
Unspecified Adult Solid Tumor, Protocol Specific
17-AAG and Irinotecan in Treating Patients With Locally Advanced or Metastatic Solid Tumors
This phase I trial is studying the side effects and best dose of 17-AAG and irinotecan in treating patients with locally advanced or metastatic solid tumors.
- Trial name
- NCT00119236
- Testing
- tanespimycin, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
Hypopituitarism
Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults With Growth Hormone Deficiency
Patients with Growth hormone (GH) deficiency often report impaired quality of life and difficulty with mental functioning. It has been suggested that GH replacement in such patients leads to improvement in cognitive function.
- Trial name
- GHD (NCT01007071)
- Testing
- Human Growth Hormone (1-134)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Hypertension
Effect of Isometric Handgrip Exercises on Blood Pressure of Hypertensive Adults
This study is designed to determine the effects of isometric handgrip exercises as compared to aerobic exercises in the hypertensive population, specifically in pre-hypertensives and those with hypertension stage I who are not…
- Trial name
- NCT05240144
- Testing
- IHG, Aerobic exercises
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Riphah International University
Functional Endoscopic Sinus Surgery, Premedication
Intranasal Versus Intravenous Dexmedetomidine for Hypotensive Anesthesia in FESS
Intranasal dexmedetomidine provided good pharmacokinetic profile. However, intravenous dexmedetomidine have been used in functional endoscopic sinus surgery for several outcomes, there is lack in studies that had compared the…
- Conditions
- Functional Endoscopic Sinus Surgery, Premedication, Analgesia
- Trial name
- NCT05604599
- Testing
- Intranasal dexmedetomidine, Intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Al-Azhar University
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