Clinical trials: Adult
Cognitive Impairment, Cognitive Flexibility
The Effects of Single Exercise Sessions on Cognitive Flexibility and Brain Functional Connectivity in Older Adults With Cognitive Impairment
Objectives: To investigate the effects of different forms (physical and mental, aerobic and resistance) of single exercise on the cognitive flexibility and brain functional connectivity of elderly individuals with cognitive…
- Trial name
- NCT07623954
- Testing
- EXERCISE TRAINING, health education materials
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Sport
Attention Deficit Disorder, Sleep Initiation and Maintenance Disorders
Better Sleep in Psychiatric Care - ADHD Pilot Study
Comorbidities, including sleep problems, are common in adult Attention Deficit Hyperactivity Disorder (ADHD). Treatment of choice for insomnia is cognitive behavioral therapy (CBT-i), but evidence is lacking for CBT-i in patients…
- Conditions
- Attention Deficit Disorder, Sleep Initiation and Maintenance Disorders, Sleep Wake Disorders
- Trial name
- BeSiP-ADHD (NCT03852966)
- Testing
- CBT-i/ADHD
- Where
- Sweden
- Volunteers
- 19 people
- Sponsor
- Karolinska Institutet
Anxiety, Depression
A Feasibility Study of a Guided Self-help Programme for Male Offenders Serving a Long-term Prison Sentence
Background: Prisoners have complex mental health needs, and there is a disproportionately higher incidence of mental health problems compared with the general population.
- Trial name
- NCT04746651
- Testing
- Guided Self Help
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Glasgow
Leukemia
Chemotherapy Followed by Donor White Blood Cells Plus Interleukin-2 in Treating Patients With Acute Myeloid or Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interleukin-2 may stimulate a person's white blood cells to kill leukemia cells.
- Trial name
- NCT00005802
- Testing
- aldesleukin, filgrastim, therapeutic allogeneic lymphocytes
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Hidradenitis Suppurativa
A Study to Assess Disease Activity and Safety of Subcutaneous Lutikizumab (ABT-981) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-Tumor Necrosis Factor (TNF) Therapy and Who Are Naïve to Biologic Therapy
Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease which includes the forming of lumps, abscesses and scars in areas of the skin such as under the breasts, under armpits, inner thighs, groin…
- Trial name
- NCT05139602
- Testing
- Lutikizumab
- Where
- 54 sites in United States, Australia and 6 more
- Volunteers
- 210 people
- Sponsor
- AbbVie
Healthy Aging, Healthy
Cause-effect Relationships Between Brain Networks and Bimanual Coordination in Older Adults
In this study, high-definition dual-site transcranial alternating current stimulation (i.e., non-invasive brain stimulation) will be applied to boost the fronto-parietal network during a bimanual coordination task in healthy…
- Trial name
- NCT04349137
- Testing
- HD-tACS
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Afrezza® Dosing Optimization Study
MKC-TI-191 is a Phase 4, single-arm, multicenter, proof-of-concept clinical trial evaluating the efficacy and safety of Afrezza, administered according to the current Afrezza prescribing information (PI) compared to a titrated…
- Trial name
- DOS (NCT04849845)
- Testing
- Afrezza Dose 1, Afrezza Dose 2
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mannkind Corporation
Healthy
Drug-Drug Interaction Study of AG120 in Healthy Subjects
An Open-Label, 2-Period, Fixed Sequence Study to Determine the Effect of Multiple Oral Doses of Itraconazole on the Single Dose Pharmacokinetics of AG 120 in Healthy Adult Subjects.
- Trial name
- NCT02831972
- Testing
- AG120, Itraconazole
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
Atopic Dermatitis
A Study in Male and Female Adult Patients With Atopic Dermatitis Treated With Dupilumab in Taiwan
Primary objective: To characterize the use patterns of phototherapy and immunosuppressants prior to dupilumab treatment for adult AD patients, who are eligible for dupilumab reimbursement in Taiwan (e.g., used regimens, reason…
- Trial name
- NCT05442645
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sanofi
Influenza
Trial to Evaluate the Efficacy of GSK Biologicals' Influenza Vaccine GSK2186877A in Adults 65 Year of Age and Older
The purpose of this study is to evaluate the efficacy of GlaxoSmithKline Biologicals' influenza vaccine GSK2186877A in adults 65 year of age and older.
- Trial name
- NCT00753272
- Testing
- GSK Bio's influenza vaccine GSK2186877A, Fluarix TM
- Where
- 274 sites in United States, Belgium and 13 more
- Volunteers
- 43,695 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Suicide, Trauma
Integrated Suicide & Trauma Therapy for Suicide Risk
The investigators have developed a novel suicide intervention, Integrated Suicide and Trauma Therapy (ISTT). ISTT combines Brief-Skills for Safer Living (Brief-SfSL)-a promising method to enhance coping skills and reduce…
- Conditions
- Suicide, Trauma, Major Depressive Disorder
- Trial name
- ISTT (NCT05613972)
- Testing
- Integrated Suicide and Trauma Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Blood Sugar; High, Overweight and Obesity
Glucagon Like Peptide 1 (GLP-1) Booster™ RCT Study
BACKGROUND GLP1 booster (GB) was designed to stimulate the endogenous production of GLP1, which in turn releases insulin, controls blood glucose level, suppresses appetite and thus helps people lose weight.
- Conditions
- Blood Sugar; High, Overweight and Obesity, Fat Loss, GLP-1
- Trial name
- RCT (NCT07141472)
- Testing
- GB
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Lawry Han
Mitochondrial Biogenesis
Examining The Effect of Blood Flow Restricted Aerobic Training on Mitochondrial Adaptations in Young Healthy Adults
This parallel-arm trial study investigates the effects of restricting arterial blood flow during cycling exercise on citrate synthase.
- Trial name
- NCT04151095
- Testing
- BFR Exercise Training, CTL Exercise Training
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Brendon Gurd, PhD
Chronic Hepatitis B Infection, Chronic Hepatitis D Infection
The Safety and Efficacy of Sequential Treatment of Ropeginterferon Alfa-2b (P1101) and Anti-PD1 in Interferon-Naive Adults With Chronic Hepatitis B or D Infection
Primary objective: To evaluate the safety and tolerability of sequential administration of P1101 and anti-PD1 in patient with chronic hepatitis B or D infection Secondary objectives: 1.
- Trial name
- NCT04638439
- Testing
- P1101 + Nivolumab + Entecavir
- Where
- 5 sites in Taiwan
- Volunteers
- 20 people
- Sponsor
- PharmaEssentia
Solid Tumors
Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of escalating doses of RMC-4630 monotherapy in adult participants with relapsed/refractory solid tumors…
- Trial name
- NCT03634982
- Testing
- RMC-4630
- Where
- 12 sites in United States
- Volunteers
- 133 people
- Sponsor
- Revolution Medicines, Inc.
Gait, Balance
Sensor Ankle Brace for Special Operations Rehabilitation
The primary purpose of this study overall is to validate a modified version of a commercially available ankle brace. Inertial measurement unit sensors will be incorporated into an existing ankle brace ("sXAB") by TayCo Brace…
- Conditions
- Gait, Balance, Biomechanical Data, Postural Control
- Trial name
- NCT07776223
- Testing
- Sensor-enabled Athletic X Ankle Brace (sXAB)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nausea and Vomiting, Chemotherapy-Induced
The Pharmacokinetic Interaction Between Oral Casopitant and Oral Dolasetron, Granisetron or Rosiglitazone in Subjects
This A Three-Part Drug-Drug Interaction Study To Evaluate Effects of Casopitant On Dolasetron, Granisetron or Rosiglitazone When Co-Administered in Healthy Adults
- Trial name
- NCT00511823
- Testing
- casopitant, dolasetron, granisetron
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Kidney Transplantation, Adult
Web-Based Multi-Resource Training on the Prevention of Urinary Tract Infections in Adult Kidney Transplant Recipients
Purpose: The study aims to examine the effect of web-based multi-source training on the prevention of urinary tract infections in adult kidney transplant recipients on clinical outcomes.
- Conditions
- Kidney Transplantation, Adult, Urinary Tract Infections, Prevention
- Trial name
- NCT05821946
- Testing
- Web-Based Multi-Source Training on the Prevention of Urinary Tract İnfections
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Bulimia Nervosa
Lisdexamfetamine for Adults With Bulimia Nervosa
The relatively high rates of bulimia nervosa (BN) in attention-deficit/hyperactivity disorder (ADHD) cohorts suggest a relationship between the two disorders.
- Trial name
- NCT03397446
- Testing
- Lisdexamfetamine dimesylate
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Aaron Keshen
Substance Abuse
A Comparison of How Likely it is That Different Tablets of Oxycodone Will be Broken up and Snorted by Adults Who Sometimes Take Drugs for Pleasure
The trial comprises an Enrollment Visit, a Qualification Phase, a Treatment Phase (including 3 treatment periods), a Final Examination, and a Follow-up Phone Call.
- Trial name
- NCT03765346
- Testing
- Oxycodone IR ADF, Oxycodone API powder
- Where
- Canada
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
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