Clinical trials: Adult
Hyperthermia
Complementary and Alternative Medicine Sauna Detoxification Study: Phase I
The purpose of this study is to determine the impact of sauna use on polychlorinated biphenyls (PCB) in the blood of healthy human adults, as well as to assess safety, feasibility, and tolerability, and effects on quality of life…
- Trial name
- NCT01905098
- Testing
- Sauna Detoxification Protocol, Observation Sessions
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Hereditary Angioedema (HAE)
Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects
This trial is looking to gain information about the safety and tolerability of an investigational treatment (SHP623) in healthy adult volunteers.
- Trial name
- NCT02663687
- Testing
- Recombinant human C1 esterase inhibitor, SHP623
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shire
Blood Flow Restriction Exercise, Resistance Training
Low Load With Blood Flow Restriction for Improving Strength, Balance, and Cognition in Older Adults
This study aims to examine the effects of low load resistance exercise with a blood flow restriction cuff on muscle strength, balance, physical performance, depression, and cognitive function in community-dwelling older adults.
- Conditions
- Blood Flow Restriction Exercise, Resistance Training, Elderly (People Aged 65 or More), Muscle Strength
- Trial name
- BFRT (NCT06962514)
- Testing
- Blood flow restriction cuff, Exercise without BFR cuff
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Sahmyook University
HIV-1-infection, Hepatitis B
B/F/TAF Switch Study for HIV-HBV Coinfection
The primary objective of this study is to evaluate the efficacy and safety of fixed dose combination (FDC) bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in adults coinfected with both HIV-1 and hepatitis B.
- Trial name
- BEST-HBV (NCT03797014)
- Testing
- B/F/TAF
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- University of Maryland, Baltimore
Dengue
TDENV PIV and LAV Dengue Prime-boost Strategy
The potential synergistic effect of administering 2 dengue vaccine candidates that were previously shown to be safe and immunogenic in humans will be evaluated in this study.
- Trial name
- NCT02239614
- Testing
- TDENV-LAV, TDENV-PIV 4 µg + alum adjuvant
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Conversion Disorder
TMS and Attentional Bias in Functional Motor Disorder
Functional motor disorders, also called motor conversion disorder, are common reasons for attendance at neurology outpatient clinics.
- Trial name
- NCT02102906
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Recurrent Colon Cancer, Extensive Stage Small Cell Lung Cancer
Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung Cancer
RATIONALE: Vaccines made from mutated ras peptides may make the body build an immune response to and kill tumor cells. PURPOSE: Phase I trial to study the effectiveness of a vaccine containing mutated ras peptides and an immune…
- Conditions
- Recurrent Colon Cancer, Extensive Stage Small Cell Lung Cancer, Stage III Pancreatic Cancer, Stage III Rectal Cancer
- Trial name
- NCT00019006
- Testing
- Detox-B adjuvant, ras peptide cancer vaccine
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Anxiety, Depression
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Major depressive and anxiety disorders are highly prevalent in the general population and are a leading cause of disability. Black adults have a high burden of depression and anxiety.
- Conditions
- Anxiety, Depression, Health Knowledge, Attitudes, Practice, Stigmatization
- Trial name
- NCT06316804
- Testing
- Video Intervention 1, Video Intervention 2, Video Intervention 3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Bronchiectasis Adult
Real Life Evaluation of the LibAirty Airway Clearance System in Adults With Bronchiectasis (RELACS)
The purpose of this study is to collect data to assess the use of the LibAirty™ System for improving bronchiectasis symptoms and healthcare resource utilization when it is used at home.
- Trial name
- NCT07135284
- Testing
- Airway clearance system
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Synchrony-Medical, Ltd
Type 2 Diabetes Mellitus
A Nurse-Led Digital Coaching Program to Improve Blood Sugar Control in Adults With Type 2 Diabetes
The goal of this clinical trial is to learn whether ChronoCoach, a nurse-led multidisciplinary digital coaching program, improves blood sugar control and self-management in adults with type 2 diabetes attending primary health…
- Trial name
- ChronoCoach (NCT07916584)
- Testing
- ChronoCoach, Usual diabetes care
- Where
- Bahrain
- Volunteers
- 160 people
- Sponsor
- Alexandria University
Oligodendroglioma, Astrocytoma, Grade II
Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma
This is a pilot neoadjuvant vaccine study in adults with WHO grade II glioma, for which surgical resection of the tumor is clinically indicated.
- Conditions
- Oligodendroglioma, Astrocytoma, Grade II, Glioma, Astrocytic, Glioma
- Trial name
- NCT02549833
- Testing
- GBM6-AD and poly-ICLC before and after surgery, GBM6-AD and poly-ICLC after surgery only
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Jennie Taylor
T2D
Peanut Consumption and Cardiovascular Disease Risk in a Chinese Population
This is a 2 parallel-arm randomized controlled study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of two servings of peanuts with an isocaloric matched refined…
- Trial name
- NCT03194152
- Testing
- Peanut, Control
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Harvard School of Public Health (HSPH)
Metastatic Non-small Cell Lung Cancer
A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)-Japan Extension
This study is to assess the pharmacokinetics (PK) and safety of SC pembrolizumab (+) berahyaluronidase alfa vs intravenous (IV) pembrolizumab, administered with chemotherapy in first line treatment of adult Japanese participants…
- Trial name
- NCT06212752
- Testing
- Pembrolizumab Formulated with Berahyaluronidase Alfa, Pemetrexed, Cisplatin
- Where
- 18 sites in Japan
- Volunteers
- 39 people
- Sponsor
- Merck Sharp & Dohme LLC
Brain Cancer, Brain Neoplasm, Primary
IDH1 Peptide Vaccine for Recurrent Grade II Glioma
Potential subjects with progressive Grade II primary brain tumor that have IDH1 positive testing from the primary tumor (initial diagnosis) will be offered this treatment study in order to test the safety of the PEPIDH1M vaccine…
- Conditions
- Brain Cancer, Brain Neoplasm, Primary, Brain Neoplasms, Recurrent, Brain Tumor
- Trial name
- RESIST (NCT02193347)
- Testing
- PEPIDH1M vaccine, Tetanus-Diphtheria Toxoid (Td), Temozolomide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Katy Peters, MD, PhD
Ornithine Transcarbamylase Deficiency
Phase 1b Study to Assess Safety, Tolerability, and Pharmacokinetics of ARCT-810 in Stable Adult Subjects With Ornithine Transcarbamylase Deficiency
Determine the safety, tolerability and pharmacokinetics of single doses of ARCT-810 in clinically stable patients (stable on standard of care treatment, e.g.
- Trial name
- NCT04442347
- Testing
- ARCT-810
- Where
- 8 sites in United States
- Volunteers
- 16 people
- Sponsor
- Arcturus Therapeutics, Inc.
Healthy Adult, Role of Vagal Stimulation in Oxytocin Release
The Effect and Mechanism of taVNS in Modulating Human Social Attention
The objectives of this study are to investigate: 1. whether non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) can enhance human interest in social stimuli in free-viewing and stressful tasks; 2.
- Conditions
- Healthy Adult, Role of Vagal Stimulation in Oxytocin Release, Role of Vagal Stimulation in Social Attention
- Trial name
- NCT07798349
- Testing
- taVNS
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy Adult Male
Oxytocin's Effects on Emotional Processing and Its Acting Routes
The main goal of this study is to investigate the modulatory effects of intranasally administrated oxytocin on the processing of emotional stimuli and its acting routes.
- Trial name
- NCT07425938
- Testing
- vasoconstrictor (Otrivin), oxytocin
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy Subjects, PK/PD
Pharmacokinetics and Pharmacodynamics of Vicagrel in Healthy Adult Subjects of Different CYP2C19
This study is a single-center, randomized, open, two-cycle crossover, clopidogrel control, multiple dosing study. The aim was to evaluate the pharmacokinetic/pharmacodynamic behavior of different metabolites of CYP2C19 in healthy…
- Trial name
- NCT03942458
- Testing
- Vicagrel 6mg, Clopidogrel 75mg
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide
This randomized, double-blind, placebo-controlled trial will evaluate whether daily calcium beta-hydroxy-beta-methylbutyrate (calcium-HMB) plus vitamin D3 preserves muscle mass, physical function, and resting metabolism in adults…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Sarcopenia, Obesity, Muscle Loss
- Trial name
- PRESERVE-HMB (NCT07760948)
- Testing
- Calcium-HMB Plus Vitamin D3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
HIV Infections
A Phase 1, Randomized, Blinded, Dose-escalation Study of rAAV1-PG9DP Recombinant AAV Vector Coding for PG9 Antibody in Healthy Male Adults.
The purpose of this study is to evaluate the safety, tolerability and immunogenicity of rAAV1-PG9DP when administered intramuscularly at different dose levels in healthy male adults.
- Trial name
- NCT01937455
- Testing
- rAAV1-PG9DP
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.