Clinical trials: Adult Congenital Heart Disease, active
Atrial Septal Defect, Patent Foramen Ovale
Canadian Adult Congenital Heart Disease Intervention Registry
The ACHDi Registry study will create a foundational database for adult congenital heart disease interventions. This Pan-Canadian Registry will collect clinical and patient-reported information that will enable the evaluation of…
- Conditions
- Atrial Septal Defect, Patent Foramen Ovale, Tetralogy of Fallot, Fontan
- Trial name
- C-ACHDiR (NCT04288596)
- Testing
- Participants undergoing ACHD intervention
- Where
- Canada
- Volunteers
- 9,000 people
- Sponsor
- University Health Network, Toronto
Friedreich Ataxia, Cardiomyopathies
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ATI-105 in Healthy Adults
The goal of this clinical trial is to learn how ATI-105 administered to healthy participants at works in the body at different doses and with or without food.
- Conditions
- Friedreich Ataxia, Cardiomyopathies, Central Nervous System Diseases, Neuromuscular Diseases
- Trial name
- NCT07869654
- Testing
- ATI-105
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Adjuvia Therapeutics, Inc.
Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism
Growing up With the Young Endocrine Support System (YESS!)
Transition from paediatric to adult endocrinology is a challenge for adolescents, families and doctors. Up to 25% of young adults with chronic endocrine disorders are lost to follow-up ('drop-out') once the young adult moves out…
- Conditions
- Congenital Adrenal Hyperplasia, Hypogonadotropic Hypogonadism, Growth Hormone Deficiency, Combined Pituitary Hormone Deficiency
- Trial name
- YESS (NCT04252001)
- Testing
- YESS! game, Snake '97, Transition-toolkit
- Where
- 7 sites in Belgium, Netherlands and 2 more
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- dr. Laura C. G. de Graaff-Herder
Congenital Heart Disease
Implementation of an Accessible Healthcare Model (ACHD STRONG): Comparing Nurse and Physician Lead Healthcare Transition Education in a RE-AIM Framework
The study includes patients with congenital heart disease (CHD), as well as their support persons and their providers, who are preparing to make the transition from pediatric to adult care for their CHD.
- Trial name
- NCT07559253
- Testing
- Accessible Care Model Visit, Recruitment Interviews, Participating Patient-Support Person Interviews
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Wisconsin, Madison
Congenital Heart Disease, Congenital Heart Defect
Swiss National Registry of Adults With Congenital Heart Disease
Due to successes in the last decades in pediatric heart surgery and cardiology, 90-95% of the children with congenital heart disease reach adult age.This results in an increasing number of adults or "grown-ups" with congenital…
- Trial name
- SACHER (NCT02258724)
- Where
- 6 sites in Switzerland
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Marfan Syndrome
Marfan Syndrome Moderate Exercise Trial II
Marfan syndrome (MFS) is a distinctive connective tissue disorder that affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection.
- Trial name
- NCT05809323
- Testing
- Exercise Intervention Group, Control Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Adult Congenital Heart Disease
Real-World Data on the Effects of Cardiac Resynchronization Therapy in Adult Patients With Congenital Heart Disease
This study aims to evaluate the real-world effects of cardiac resynchronization therapy (CRT) in adult patients with congenital heart disease (ACHD).
- Trial name
- RECORD-CHD (NCT06969924)
- Testing
- Cardiac resynchronization therapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Epilepsy (treatment Refractory)
Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale（PREDICT-PFO Trial）
Patent foramen ovale (PFO) is the most common cause of right-to-left shunt (RLS) in the adult heart, with a prevalence of approximately 25% in the general population.
- Trial name
- PREDICT-PFO (NCT06863350)
- Testing
- patent foramen ovale closure
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sichuan University
Congenital Heart Disease, Congenital Heart Defect
Peer Coaching Intervention in Young Adults With Congenital Heart Disease
The purpose of the study is to evaluate a peer coaching intervention in young adults with congenital heart disease.
- Trial name
- CHASM in ACHD (NCT04271358)
- Testing
- Peer Health Coaching
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Congenital Heart Disease, Behavior, Health
Improving Congenital Heart Disease Care
The theory-informed digital health intervention, called as "Empower My Congenital Health (EmpowerMyCH)" aims to activate and engage ACHD patients in building confidence toward navigating the adult healthcare system.
- Conditions
- Congenital Heart Disease, Behavior, Health, Quality of Life, Empowerment, Patient
- Trial name
- EmpowerMyCH (NCT06581484)
- Testing
- Digital patient empowerment intervention
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Francisco
Adult Congenital Heart Disease, Congenital Heart Disease
Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease
The purpose of this study, entitled "Psychological trauma, post-traumatic stress disorder, and resilience in adults with congenital heart disease in a large population sample", is to evaluate for exposures during a lifetime with…
- Conditions
- Adult Congenital Heart Disease, Congenital Heart Disease, PTSD
- Trial name
- PTSD in ACHD (NCT06952933)
- Testing
- Other
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Heterozygous Familial Hypercholesterolemia (HeFH)
EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
A phase 1/2, two-part trial consisting of an open label dose-escalation part and a randomized, double blind, placebo-controlled part to investigate safety, tolerability, pharmacokinetics, and efficacy with EDIT-401 gene editing…
- Trial name
- NCT07894887
- Testing
- Drug: EDIT-401
- Where
- 2 sites in Australia
- Volunteers
- 56 people
- Sponsor
- Editas Medicine, Inc.
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Marfan Syndrome
Clinical and Psychosocial Factors Associated With Physical Activity Level in Adults With Marfan Syndrome
Background. Marfan syndrome is a genetic connective tissue disorder with cardiovascular and musculoskeletal involvement. Despite clinical advances, many patients exhibit low levels of physical activity, influenced by clinical and…
- Trial name
- NCT07419386
- Testing
- Adults with Marfan syndrome
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- University of Oviedo
Congenital Heart Disease
Effect of Sacubitril-Valsartan on Cardiac Structure and Function
The purpose of this study is to compare changes in cardiac structure and function, biomarkers, and patient reported outcomes between adults with congenital heart disease (ACHD) randomized to angiotensin receptor-neprilysin…
- Trial name
- NCT06693674
- Testing
- Entresto Pill
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Osteogenesis Imperfecta (OI), Osteogenesis Imperfecta
Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups.
- Trial name
- OI Cardio (NCT07287241)
- Testing
- Imaging evaluation, Echocardiography
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Aortic Coarctation
Aortic Stiffness by CMR in Aortic Coarctation
This study investigates the correlation between medium-term systemic blood pressure control and aortic stiffness index in adults following coarctation stenting, using cardiac magnetic resonance (CMR) imaging.
- Trial name
- NCT06740461
- Volunteers
- 30 people
- Sponsor
- Assiut University
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adult Congenital Heart Disease
Prognosis in Adult Patients With Congenital Heart Disease
This is a mono-center observational ambispective study in which adult patients with congenital heart disease evaluated at our institution will be enrolled.
- Trial name
- PRO-ACHD (NCT06723704)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Adult Congenital Heart Disease, Symptom Clusters
AI-Enabled Frailty Risk Prediction in Adult Congenital Heart Disease
The goal of this three-year mixed-methods observational study with an embedded randomized controlled trial is to develop and validate a frailty risk prediction model and evaluate an artificial intelligence-based voice emotion…
- Conditions
- Adult Congenital Heart Disease, Symptom Clusters, Frailty, Risk Prediction Model
- Trial name
- NCT07479654
- Testing
- AI-Based Voice Emotion Detection-Guided Counselling, Usual Care (Control)
- Volunteers
- 410 people
- Sponsor
- Mackay Memorial Hospital