Clinical trials: Adult Depression
Major Depressive Disorder
Major Depressive Disorder Study In Adults
A study to obtain safety and tolerability data
- Trial name
- NCT00049972
- Testing
- paroxetine CR
- Where
- 71 sites in United States
- Volunteers
- 646 people
- Sponsor
- GlaxoSmithKline
Mood Disturbance, Depressive Symptoms
Examining the Effectiveness of a Tablet Video Game on Mood and Cognition
Sustained negative mood and depression are characterized by functional impairment, and significant reduction in quality of life.
- Trial name
- THRIVE (NCT05447091)
- Testing
- LOH game- high dose, LOH game- low dose
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hebrew University of Jerusalem
Major Depressive Disorder
Pilot Decentralized Trial
The purpose of this study is to collect biologically-based data for defining predictors and correlates of the effects of ALTO-100.
- Trial name
- NCT05419869
- Testing
- ALTO-100 PO Tablet
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Alto Neuroscience
Depression
Study to Compare the Use of a Behavioral Health App Versus Care As Usual for 16-22 Year Olds with Depression
Randomized Controlled Trial comparing a coach-enhanced digital cognitive behavioral intervention (d-CBI) (RxWell) + treatment as usual (TAU) versus TAU alone for moderate depression as determined by Patient Health Questionnaire…
- Trial name
- NCT05159713
- Testing
- dCBI, Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 185 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Study of Escitalopram in Adult Patients With Major Depressive Disorder
Escitalopram is the S-enantiomer of citalopram. Both escitalopram and citalopram are selective serotonin reuptake inhibitors (SSRIs) and are used to treat depression in adults.
- Trial name
- NCT00108979
- Testing
- Escitalopram
- Where
- 9 sites in United States
- Volunteers
- 240 people
- Sponsor
- Forest Laboratories
Schizophrenia, Treatment Resistant Depression
Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
This pilot open-label study examines the effects of a combination of dasatinib plus quercetin - two drugs that have known senolytics properties - on physiological aging in older individuals with depression or schizophrenia.
- Conditions
- Schizophrenia, Treatment Resistant Depression, Aging, Premature
- Trial name
- NCT05838560
- Testing
- Dasatinib, quercetin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Chronic Pain, Depression
The Impact of Comorbid Chronic Pain on Older Adults With Depression in Behavioral Activation
This qualitative nested sub-study will aim to explore how chronic pain (as defined as pain lasting for more than 3 months) impacts older adults' depression and treatment in a brief psychological therapy of behavioral activation…
- Trial name
- NCT05646628
- Testing
- Qualitative Interviews
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Teesside University
Depression, Anxiety
Effect of Two Probiotic Formulations on Mental Health and Mood Biomarkers in Adults With Depressive Symptoms
This is a 3-arm, parallel-group, randomized, double-blind, placebo-controlled pilot trial. Sixty adults presenting with depressive symptoms will be randomly allocated to one of 3 groups comprising (1) Bifidobacterium adolescentis…
- Trial name
- NCT05564767
- Testing
- B. adolescentis Bif-038, Lacticaseibacillus rhamnosus, LGG® and Bifidobacterium, BB-12®
- Where
- Australia
- Volunteers
- 62 people
- Sponsor
- Chr Hansen
Anhedonia, Depressed Mood
Depressed Mood and Anhedonia in Healthy Adults
The aim of this study is to evaluate the effect of nutraceutical supplement on depressed mood and anhedonia in volunteers after 8 weeks of consumption.
- Trial name
- MOOD5 (NCT05306093)
- Testing
- Nutraceutical, Maltodextrin
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Major Depressive Disorder (MDD)
Single Dose Oral Bioequivalence Study of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets
An open label, randomized, three-period, three-treatment [Treatment A (test product administered without water), Treatment B (test product administered with water) and Treatment C (Reference product administered with water)]…
- Trial name
- NCT05417087
- Testing
- Vortioxetine Hemihydrobromide Orally Disintegrating Tablets, Vortioxetine Hydrobromide Tablets
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Seasons Biotechnology (Taizhou) Co., Ltd.
Depression
Antidepressant Adherence for Depressed Adults in Primary Care
The goal of this study is to test ways to help people improve their health and manage their medication for depression. This study will measure both medication adherence and depression outcomes.
- Trial name
- NCT06496646
- Testing
- Arm 1 intervention, Arm 2 Intervention
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- University of Pennsylvania
Treatment Resistant Depression, Treatment Resistant Depression (TRD)
A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial
Major depressive disorder (MDD) is a significant public health problem and leading cause of worldwide disability. Treatment resistance is common in MDD, however, for these individuals, targeted noninvasive brain stimulation is an…
- Trial name
- SPARC-TMS (NCT07227103)
- Testing
- Neuronavigated robotic-enabled TMS, NRX-101
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- NeuroRx, Inc.
Bipolar I Disorder
Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.
Phase II study for patients with Bipolar 1 Disorder experiencing major depressive episode. Patient eligible for enrollment will be randomized (like flipping a coin) to either active drug (LB-102 or placebo).
- Trial name
- Illuminate1 (NCT07494305)
- Testing
- LB-102
- Where
- 26 sites in United States
- Volunteers
- 320 people
- Sponsor
- LB Pharmaceuticals Inc.
Anxiety, Depression
Implementation of Group Problem Management Plus (PM+) in Adult Syrian Refugees in Turkey: RCT (STRENGTHS)
To implement Group Problem Management Plus (PM+) in Syrian refugees with this RCT to evaluate feasibility, acceptability, effectiveness and cost-effectiveness of the culturally adapted Group PM+ intervention for adult Syrian…
- Conditions
- Anxiety, Depression, Posttraumatic Stress Disorder, Psychological Distress
- Trial name
- (STRENGTHS) (NCT03960892)
- Testing
- Problem Management Plus (PM+)
- Where
- Turkey (Türkiye)
- Volunteers
- 369 people
- Sponsor
- Istanbul Sehir University
Healthy, Psychological Distress
The Effects of the Somatic Intervention 'Dance-Walk' on Body Awareness, Vitality, and Mental Health in Help-Seeking Adults: a RCT Study
The goal of this clinical trial is to learn if a movement program called "Dance-Walk" can improve body awareness, energy levels, and mental health in adults seeking mental health support.
- Conditions
- Healthy, Psychological Distress, Stress, Depression Disorders
- Trial name
- DANCEWALK (NCT07024901)
- Testing
- Dance-walk
- Where
- Lithuania
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Major Depressive Disorder
EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT
The aim of this study is to evaluate the effects of transranial pulse stimulation (TPS) on young adults with symptoms of depression in Hong Kong.
- Trial name
- TPS (NCT05006365)
- Testing
- Transcranial Pulse Stimulation
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Medical Conditions, Depression
FACE-PC: Family-Centered Care for Older Adults With Depression and Chronic Medical Conditions in Primary Care
Comorbid depression and multiple medical conditions in older adults are a serious public health problem. As an important facilitator of health-related activities, families are already involved in various aspects of…
- Trial name
- FACE-PC (NCT03094871)
- Testing
- FACE-PC
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Anxiety, Depression
Internet-delivered Cognitive Behaviour Therapy for Older Adults With Anxiety
The purpose of this study is to determine whether tailored internet-administrated cognitive behaviour therapy (ICBT) is a feasible approach in the treatment of anxiety symptoms and comorbid depressive symptoms in older adults.
- Trial name
- NCT02403557
- Testing
- Waitlist, Tailored Internet-delivered CBT
- Volunteers
- 66 people
- Sponsor
- Linkoeping University
Pain Management, Thoracic Trauma
Comprehensive Multicenter Study on the Management of Acute Pain Following Thoracic Combat-Related Trauma in Ukraine
This study is a multicenter clinical trial conducted in Vinnytsia, Rivne, and Lviv, Ukraine, focusing on the management of acute pain following thoracic injuries sustained during combat.
- Conditions
- Pain Management, Thoracic Trauma, Pulmonary Function, Quality of Life
- Trial name
- CMS-APT-UA (NCT07380789)
- Testing
- Cryoablation, Radiofrequency ablation alone
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Lviv National Medical University
Major Depressive Disorder
A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend
- Trial name
- NCT07592689
- Testing
- DT120
- Where
- 30 sites in United States
- Volunteers
- 165 people
- Sponsor
- Definium Therapeutics US, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.