Clinical trials: Adult Depression
Depressive Symptoms
Cognitive Stimulation Program With Virtual Reality for Older Adults With Depressive Symptoms
The aim of this pilot RCT is the development, implementation, and evaluation of a cognitive stimulation program with virtual reality for individuals aged 65 or older who have depressive symptoms and attend Portuguese day centers.
- Trial name
- NCT07710222
- Testing
- Cognitive stimulation program
- Volunteers
- 60 people
- Sponsor
- Grupo Lusófona
Depression, Eating Disorders
Implementation of Project YES in Ambulatory Adolescent & Young Adult Medicine
This study tests a suite of single-session intervention (SSI) targeting risk factors for depression and eating disorders among adolescents and young adults.
- Conditions
- Depression, Eating Disorders, Anxiety
- Trial name
- NCT06359951
- Testing
- Project YES
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
PTSD - Post Traumatic Stress Disorder
REVEAL Study - Diagnostic Testing for PTSD Using the Senseye Diagnostic Tool
The goal of the REVEAL PTSD study is to test how well the Senseye DT works as a diagnostic test for Post-traumatic Stress Disorder (PTSD) in adults 18 and older who are experiencing one or more symptoms that might be related to…
- Trial name
- NCT07280065
- Testing
- Senseye Diagnostic Tool (DT), Clinician Administered PTSD Scale for DSM-5, Revised Version
- Where
- 6 sites in United States, Australia
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Senseye, Inc.
Suicidal Behavior, Self-Harm, Deliberate
Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults
This randomized controlled trial will evaluate two approaches to achieving the aspirational goal of Zero Suicide within a health system: 1) Zero Suicide Best Practices initiated through a zero suicide quality improvement…
- Conditions
- Suicidal Behavior, Self-Harm, Deliberate, Suicidal Ideation, Suicide
- Trial name
- Step2Health (NCT03092271)
- Testing
- Stepped Care for Suicide Prevention, Zero Suicide Quality Improvement
- Where
- 2 sites in United States
- Volunteers
- 301 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness of treatment with vortioxetine on participant goal achievement after a change in antidepressant medication for the treatment of major depressive disorder (MDD).
- Trial name
- NCT02972632
- Testing
- Vortioxetine
- Where
- 25 sites in United States
- Volunteers
- 123 people
- Sponsor
- Takeda
Preventive Intervention
Preventive Intervention to Promote Healthy Ageing
The aim of the project is the support of healthy ageing of older adults in acommunity. Efficient educational and psychosocial intervention will besuggested and verified to prevent anxiety, depression, and cognitivedisorders of…
- Trial name
- NCT05637177
- Testing
- Anging Wisely, Music therapy, Reminiscence therapy
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Ostrava
Suicide, Depression
Adaptation of a French E-health Tool for Suicide Prevention in Young Populations
"France's suicide rate is among the highest in Europe, with the young among the more at risk. Several European projects have demonstrated the effectiveness of using e-tools in suicide prevention particularly for hard-to-reach…
- Conditions
- Suicide, Depression, Psychological Distress, Anxiety Disorders
- Trial name
- E-psYouth (NCT04946955)
- Testing
- Application and website with or without promotion
- Where
- France
- Volunteers
- 12,000,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Major Depressive Disorder
A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder
Major depressive disorder (MDD) is a serious medical illness associated with significant suicidal risk and marked disability. Despite the availability of numerous treatments, achievement of consistent and favorable long-term…
- Trial name
- NCT03538691
- Testing
- Brexpiprazole, Antidepressant therapy
- Where
- United States
- Volunteers
- 1,149 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder
Study of ALTO-300 in MDD
The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics.
- Trial name
- NCT05922878
- Testing
- ALTO-300
- Where
- 75 sites in United States
- Volunteers
- 325 people
- Sponsor
- Alto Neuroscience
Depression, Loneliness
Empower@Home:Connected - Feasibility and Preliminary Effect Study
This single-group trial will evaluate the feasibility and preliminary effect of a novel group-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Loneliness, Social Isolation, Depressive Disorder
- Trial name
- NCT05732740
- Testing
- Empower@Home:Connected
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Michigan
ADHD
Network Analysis of Adult MDD and ADHD
The study is an investigation to determine co-morbid symptoms between adult major depressive disorder (MDD) and adult attention-deficit hyperactivity disorder (ADHD) using a novel statistical technique called network analysis.
- Trial name
- NCT04504474
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Health Sciences North Research Institute
Caregiver Burden, Caregiver Burnout
Peer Support for Family Caregivers of Older Adults Living With Dementia
Family caregivers of people living with dementia are at high risk of poor health when caregiving for their loved one. Peer Support for Family Caregivers of Older Adults Living with Dementia (Pair 2 Care©) is a simple…
- Conditions
- Caregiver Burden, Caregiver Burnout, Caregiver Anxiety, Alzheimer Disease Dementia
- Trial name
- Pair 2 Care (NCT07868718)
- Testing
- Peer Support, Usual Care
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Ohio State University
Obesity & Overweight, Depression Disorders
Physical Activity for Depressive Symptoms in Adults With Obesity: A Randomized Controlled Feasibility Trial
The goal of this clinical trial is to learn whether a supervised physical activity program can be successfully carried out for adults living with obesity and depression, and whether people are willing to take part in this kind of…
- Trial name
- NCT07836582
- Testing
- Supervised Physical Activity Program
- Where
- 3 sites in Canada
- Volunteers
- 26 people
- Sponsor
- Universite du Quebec en Outaouais
Autism Spectrum Disorder, Depression
TMS for Adults With Autism and Depression
The goal of this proposal is to investigate whether a standard rTMS protocol for depression, including multiple sessions applied to left dorsolateral prefrontal cortex (DLPFC) results in reduction of depressive symptoms for adult…
- Conditions
- Autism Spectrum Disorder, Depression, Depressive Disorder, Major Depressive Disorder
- Trial name
- TAD (NCT02939560)
- Testing
- NeuroStar® TMS device (Neuronetics, Atlanta, GA)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Communication, Anxiety
AYA-PeerConnect: A Communication Coaching Intervention for Adolescent/Young Adult Cancer Survivors (AYACS)
This research is being done to test a communication coaching intervention pilot designed to improve communication quality between adolescent/young adult cancer survivors (AYACS) and their friends/peers.
- Conditions
- Communication, Anxiety, Depression, Social Isolation
- Trial name
- NCT07454460
- Testing
- Asynchronous coaching and artificial intelligence (AI) Yoodli coach sessions
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Milton S. Hershey Medical Center
Major Depressive Disorder (MDD)
A Study to Assess Adverse Events of Fosigotifator (ABBV-CLS-7262) in Adults With Major Depressive Disorder
Major depressive disorder (MDD; depression) is a mood disorder that causes a continued feeling of sadness and loss of interest. It is a common and serious illness that can cause both emotional and physical symptoms such as…
- Trial name
- NCT06618118
- Testing
- Fosigotifator
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- AbbVie
Depression
Antidepressant Treatment of AIDS Related Depression.
To test the effectiveness treating AIDS related depression with imipramine hydrochloride. Depression syndromes are commonly associated with chronic, disabling, and fatal diseases.
- Trial name
- NCT00000390
- Testing
- Imipramine hydrochloride
- Where
- United States
- Sponsor
- GEIGY Pharmaceuticals
Psoriasis, Depressive Symptoms
Smart Phone Delivered Cognitive Behavioral Therapy for Adults With Psoriasis and Co-Morbid Depression Symptoms
A single arm, pilot study in which all eligible participants will be enrolled in an 8-week coach-guided smartphone delivered CBT program. The full duration of the program, with follow-up interview, will be 9 weeks.
- Trial name
- NCT06216691
- Testing
- Coach-guided smartphone delivered CBT program.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Depression, Anxiety
Development of a Multiplatform Mental Health Mobile Tool
Mobile applications for mental health (MAMH) have shown great potential for delivering digital interventions for the general population. However, most of these apps do not have evidence on how they work.
- Trial name
- NCT05997849
- Testing
- Mobile application
- Where
- Chile
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Talca
Race-related Stress, Depression, Anxiety
Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black…
- Conditions
- Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
- Trial name
- ACT for SCD (NCT05685368)
- Testing
- ACT for SCD
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Children's Hospital Los Angeles
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