Clinical trials: Adult Depression
Depression Anxiety Disorder
Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety
Major depression and anxiety disorders are leading causes of disability worldwide. These mental disorders deeply impact social functioning and physical health in more than 300,000-600,000 Canadians over the age of 60.
- Trial name
- NCT03607708
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Enhancement Program (HEP)
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Lady Davis Institute
Depression
Feasibility of Telehealth Problem-Solving Therapy for Depressed Homebound Older Adults
This study will test the feasibility and effectiveness of therapy given via teleconferencing to depressed homebound older adults.
- Trial name
- NCT00903019
- Testing
- Tele-Problem-Solving Therapy, In-Person PST, Attention control
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Depression, Postpartum, Postpartum Depression
A Study to Assess the Efficacy, Safety, and Tolerability of Oral NORA520 in Adults With Severe Postpartum Depression
The purpose of this research study is to test the study drug, NORA520, as a possible treatment for severe postpartum depression (PPD).
- Conditions
- Depression, Postpartum, Postpartum Depression, Post-partum Depression, Postnatal Depression
- Trial name
- NuMom (NCT06285916)
- Testing
- NORA520 Dose 1, NORA520 Dose 2
- Where
- 18 sites in United States
- Volunteers
- 93 people
- Sponsor
- TWi Biotechnology, Inc.
Major Depressive Disorder (MDD)
Food Effect Bioavailability Study of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets
An open label, randomized, two-period, two-treatment [Treatment A (Investigational product administration under fasting condition) vs Treatment B (Investigational product administration under fed condition)], two-sequence…
- Trial name
- NCT05416957
- Testing
- Vortioxetine Hemihydrobromide Orally Disintegrating Tablets
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seasons Biotechnology (Taizhou) Co., Ltd.
Rumination, Worry
Evaluating the Effects of a Self-help Mobile Phone Application on Worry and Overthinking in Young Adults Aged Between 16 and 24.
This project seeks to understand if a new self-help mobile phone application (called MyMoodCoach) is effective at reducing worry and overthinking, prominent risk factors that predict reduced well-being and poor mental health.
- Conditions
- Rumination, Worry, Repetitive Negative Thinking
- Trial name
- NCT04950257
- Testing
- digital CBT self-help including specific intervention elements to target worry and rumination.
- Where
- United Kingdom
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Depression
The Effect of a Selective Serotonin Reuptake Inhibitor on Gait, Balance, and Bone Metabolism in Older Adults
The purpose of this study is to examine the effects of sertraline treatment of depression in older adults on gait stability, balance recovery reactions, and markers of bone metabolism.
- Trial name
- NCT02228005
- Testing
- Sertraline
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Bipolar Disorder Depression
Study of ABX-002 for the Adjunctive Treatment of Depressive Episodes Associated With Bipolar Disorder in Adults
The goal of this clinical trial is to learn if ABX-002 added to participants' existing treatment(s) can improve clinical symptoms of depression and to learn about potential effects on brain chemistry that may correlate with…
- Trial name
- NCT06869187
- Testing
- ABX-002
- Where
- 14 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Autobahn Therapeutics, Inc.
Depression, Anxiety
Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Childhood trauma is remarkably prevalent, and it has long lasting impact on mental health and neural development. This trial aims to see whether the 8-week mindfulness based intervention can reduce stress related psychological…
- Conditions
- Depression, Anxiety, PTSD, Trauma, Psychological
- Trial name
- NCT02447744
- Testing
- Mindfulness based intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Suicide, Trauma
Integrated Suicide & Trauma Therapy for Suicide Risk
The investigators have developed a novel suicide intervention, Integrated Suicide and Trauma Therapy (ISTT). ISTT combines Brief-Skills for Safer Living (Brief-SfSL)-a promising method to enhance coping skills and reduce…
- Conditions
- Suicide, Trauma, Major Depressive Disorder
- Trial name
- ISTT (NCT05613972)
- Testing
- Integrated Suicide and Trauma Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Obesity, Depression
The Montreal Neighbourhood Networks and Healthy Aging Panel
Social networks, social capital, i.e., network-accessed resources, and neighbourhood environments have been shown associated with a range of health behaviours and conditions, including obesity, physical activity, nutrition, and…
- Conditions
- Obesity, Depression, Physical Activity, Hypertension
- Trial name
- MoNNET-HA (NCT03369496)
- Testing
- Social capital; Neighborhood environment
- Volunteers
- 2,707 people, healthy volunteers welcome
- Sponsor
- Queen's University
Sickle Cell Disease, Depression
Cognitive Behavioral Therapy and Real-time Self-management Intervention for SCD Via Mobile Applications
Patients with sickle cell disease (SCD) experience significant depressive symptoms that currently go unrecognized and under-treated.
- Conditions
- Sickle Cell Disease, Depression, Anxiety
- Trial name
- CaRISMA (NCT02384590)
- Testing
- Computerized cognitive behavioral therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Healthy Adult, Volunteer
Comparing 360-degree VR Video of Local vs Overseas Environment on Psychological Health
Medical students frequently experience high levels of stress, anxiety, and depression due to intense academic pressures. While spending time outdoors in nature is a proven way to reduce these negative feelings, students rarely…
- Conditions
- Healthy Adult, Volunteer, Psychological Stress, Anxiety, and Depression Associated With Academic Pressure
- Trial name
- NCT07447310
- Testing
- Local Environment 360-degree VR Video, Overseas Environment 360-Degree VR Video
- Where
- Malaysia
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Depression, Anxiety, Cancer
Evaluating a Tailored Cognitive Behavioral Therapy for Adolescent and Young Adult Cancer Patients
This project's overall goal is to test the feasibility, acceptability and efficacy of two coach-assisted, computer-based, cognitive- behavioral therapy (C-CBT) interventions in treating depression and anxiety in adolescent and…
- Trial name
- NCT04773197
- Testing
- Beating the Blues (BtB), Entertain Me Well (EMW), Coaching
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Michigan Rogel Cancer Center
Schizophrenia, Bipolar Disorder
Evaluation of the In SHAPE Fitness Intervention for Adults With Serious Mental Illness
Few studies targeting obesity in serious mental illness have reported clinically significant risk reduction, and non have been replicated in community settings or demonstrated sustained outcomes after intervention withdrawal.
- Conditions
- Schizophrenia, Bipolar Disorder, Schizoaffective Disorder, Major Depressive Disorder
- Trial name
- NCT02334228
- Testing
- In SHAPE Lifestyles, Health Club Membership and Education
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Major Depressive Disorder
Safety Study of F2695 SR in Major Depressive Disorder
The purpose of this study is to evaluate the long- term safety of F2695-SR in the treatment of adults with major depressive disorder.
- Trial name
- LVM-MD-04 (NCT01034267)
- Testing
- F2695 SR
- Where
- 68 sites in United States
- Volunteers
- 828 people
- Sponsor
- Forest Laboratories
Fermented Food, Depression
The Effect of Probiotic Foods on Depression
This exploratory study examined whether different frequencies of consuming three fermented foods commonly eaten in Türkiye-kefir, tarhana, and mixed pickles-were associated with short-term changes in body measurements and…
- Trial name
- NCT07846072
- Testing
- Individualized diet excluding fermented foods, Lower-frequency fermented-food dietary intervention, Higher-frequency fermented-food dietary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nadide Gizem Tarakci Filiz
Chronic Pain, Depression
A Behavioral Intervention for Depression and Chronic Pain in Primary Care (Relief-Hybrid)
Chronic pain and depression frequently co-exist in late and mid-life and contribute to increased disability, high health care costs, psychiatric comorbidity, and suicide.
- Trial name
- NCT04290845
- Testing
- Relief-Hybrid
- Where
- 4 sites in United States
- Sponsor
- Weill Medical College of Cornell University
Cancer, Cognitive Dysfunction
Feasibility and Acceptability of a Virtual 'Coping With Brain Fog' Intervention for Young Adults With Cancer
Cancer-related cognitive problems, also known as "brain fog", have a significant impact on patients with cancer and cancer survivors.
- Conditions
- Cancer, Cognitive Dysfunction, Cognitive Impairment, Adolescents
- Trial name
- NCT05115422
- Testing
- 'Coping with Brain Fog' program
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Depression
Comparing Differing Financial Incentive Structures for Increasing Antidepressant Adherence Among Adults
The investigators will test using financial incentives by leveraging decision-making biases to improve adherence to antidepressants among adults newly prescribed antidepressants.
- Trial name
- ADAPT (NCT03441399)
- Testing
- Financial incentives
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
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