Clinical trials: Adult Depression
Treatment Resistant Depression
Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine
The purpose of this research study is to compare the antidepressant effect of lithium versus placebo in adults receiving ketamine.
- Trial name
- NCT03290963
- Testing
- Lithium, Ketamine
- Where
- United States
- Sponsor
- William V. Bobo, M.D.
Major Depressive Disorder, Alcohol Use Disorder
Cognitive Dysfunction in the Addictions Study - Project 4 (P4)
The prefrontal cortex, although well established as an efficacious target for the treatment of major depressive disorder (MDD), has recently come into favour as a therapeutic target for alcohol use disorders (AUD).
- Trial name
- CDiA-P4 (NCT06299787)
- Testing
- intermittent theta burst stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Irritable Bowel Syndrome (IBS), Pain
Study on Treatment Mechanisms and Efficacy Prediction of Individualized Transcranial Magnetic Stimulation in Adults With Irritable Bowel Syndrome Using Multimodal MRI and High-Throughput Sequencing
The goal of this clinical trial is to explore if "individualized repetitive Transcranial Magnetic Stimulation (TMS)" works to improve symptoms in adults with Irritable Bowel Syndrome (IBS).
- Conditions
- Irritable Bowel Syndrome (IBS), Pain, Depressive Disorder, Major, Moderate
- Trial name
- NCT07345377
- Testing
- Individualized TMS Intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Emotional Disorder, Trauma and Stressor Related Disorders
Efficacy of a Transdiagnostic Guided Internet-Delivered Intervention for Emotional, Trauma and Stress-Related Disorders.
Emotional, trauma and stress-related disorders show high incidence, prevalence, morbidity, and comorbidity rates in Mexico. In recent decades, research findings indicate that cognitive behavioral interventions, from a…
- Conditions
- Emotional Disorder, Trauma and Stressor Related Disorders, Anxiety Disorders, Depression
- Trial name
- NCT05225701
- Testing
- Transdiagnostic guided internet-delivered intervention with synchronous assistance, Transdiagnostic self-guided internet-delivered intervention
- Where
- 6 sites in Mexico
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Depressive Symptoms
Berries, Bugs, and the Blues
This study aims to investigate the impact of daily freeze-dried blueberry powder consumption on the gut microbiota, fecal short chain fatty acids, and depressive symptom severity in 40older, sedentary adults with depressive…
- Trial name
- NCT05817383
- Testing
- Freeze-dried Blueberry Powder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hebrew SeniorLife
Depression
Telehealth Depression Treatments for Older Adults
This study aims to find an effective and sustainable approach to reducing disparities in accessing mental health services for an underserved and growing population group of low-income, racially diverse, homebound older adults.
- Trial name
- NCT02600754
- Testing
- IT-PST, IT-SCM
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- University of Texas at Austin
Anxiety Disorders, Depressive Disorder
Problem Management Plus (PM+) in Chile: a Pilot Randomized Controlled Trial of a Psychological Transdiagnostic Intervention Delivered in Primary Health Care
This study aims to evaluate the implementation outcomes of a pilot randomized controlled trial and to assess the preliminary efficacy of Problem Management Plus (PM+) in reducing symptoms of depression and anxiety among users at…
- Trial name
- NCT06988332
- Testing
- Problem Management Plus (PM+)
- Where
- Chile
- Volunteers
- 56 people
- Sponsor
- University of Chile
Depression
Social Connectedness Group Intervention in Depression
This study evaluates the feasibility of the Groups for Health (G4H) intervention for adults accessing support for depression in the UK.
- Trial name
- G4H-A (NCT03446963)
- Testing
- Groups for Health
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Nottingham
Testicular Cancer
Young Adult Latino Testicular Cancer Survivors: a Pilot Study of Goal-Focused Emotion Regulation Therapy (GET)
Testicular cancer diagnosis and treatment, especially given its threat to sexuality and reproductive health, can be distressing in the formative period of young adulthood.
- Trial name
- NCT07615998
- Testing
- Goal-focused Emotion-regulation Therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, Irvine
Depressive Symptoms
Feasibility and Effects of a Blended Baduanjin Exercise and Green Tea Consumption Program on Depressive Symptoms, Gut Microbiota and Quality of Life in Older Adults
Depression is a common mental health issue in older adults, often manifesting as insomnia, low mood, vague somatic complaints, cognitive decline, and recurrent thoughts of death or suicide.
- Trial name
- NCT07687940
- Testing
- blended Baduanjin and Green Tea consumption program, Non-treatment control
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Hong Kong Baptist University
Depressive Symptoms
Computerized Cognitive Training in Young Adults With Depression
The purpose of the study is to examine the benefits and mechanism of action of computerized cognitive training (CCT) on mood, neuropsychological deficits, everyday functioning, and brain activity among young adults with a range…
- Trial name
- NCT03869463
- Testing
- Computerized Cognitive Training, Control
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Queens College, The City University of New York
Self-Harm, Depression
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group…
- Conditions
- Self-Harm, Depression, Suicide
- Trial name
- NCT04005053
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Post Intensive Care Syndrome, Narrative Medicine
Effect of Pediatric Intensive Care Unit Diaries on PICS-p
When children become very sick and need to stay in a Pediatric Intensive Care Unit (PICU), it can have a big impact on their recovery and their family's well-being.
- Conditions
- Post Intensive Care Syndrome, Narrative Medicine, Post Traumatic Stress Disorder, Anxiety
- Trial name
- PICS-p (NCT06310109)
- Testing
- PICU diary
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- Bambino Gesù Children's Hospital IRCCS
Adult Glioblastoma, Depression
Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive Glioblastoma
This clinical trial is studying magnetic resonance spectroscopy imaging in predicting response in patients to vorinostat and temozolomide in patients with recurrent, progressive, or newly diagnosed glioblastoma.
- Conditions
- Adult Glioblastoma, Depression, Recurrent Adult Brain Tumor
- Trial name
- NCT01342757
- Testing
- vorinostat, temozolomide, magnetic resonance spectroscopic imaging
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Major Depressive Disorder, Alzheimer Disease
Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD)…
- Conditions
- Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases
- Trial name
- NCT05976659
- Testing
- Transcranial direct current stimulation (tDCS); Transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hebrew SeniorLife
Depression and Self-Harm
RCT of the Clinical and Cost Effectiveness of Cognitive Behaviour Therapy (CBT) Delivered Remotely Versus Treatment as Usual in Adolescents and Young Adults With Depression Who Repeatedly Self-harm
A randomized controlled trial to test the whether remote delivery of cognitive based therapy (CBT) is clinically and cost effective when compared to treatment as usual in adolescents and young adults with depression who self-harm.
- Trial name
- eDASH (NCT02377011)
- Testing
- Problem solving cognitive behaviour therapy (PS CBT)
- Where
- 4 sites in United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Nottingham
Depressive Disorder, Major, Adult Attention Deficit Hyperactivity Disorder
Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD
In the presence of attention deficit hyperactivity disorder (ADHD) together with additional psychiatric diseases, the treatment process and prognosis of both ADHD and psychiatric comorbidity are adversely affected.
- Conditions
- Depressive Disorder, Major, Adult Attention Deficit Hyperactivity Disorder, Suicide
- Trial name
- NCT03721588
- Testing
- Clinical interviews, psychometric scales were applied.
- Volunteers
- 96 people
- Sponsor
- Bozyaka Training and Research Hospital
Cystic Fibrosis (CF)
Progressive Muscle Relaxation in Pulmonary Rehab for Quality of Life, Mental Health, and Sleep in Cystic Fibrosis
This study, called PRIME-CF, will look at how adding progressive muscle relaxation (PMR) to a typical pulmonary rehabilitation (PR) program might help adults with cystic fibrosis (CF).
- Trial name
- PRIME-CF (NCT06592742)
- Testing
- Pulmonary rehabilitation (alone), Intervention group (PR + PMR)
- Where
- Romania
- Volunteers
- 22 people
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Depression, Depressive Disorder, Major
Decentering and Relapse/Recurrence in MBCT for Depression in Adults
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions.
- Conditions
- Depression, Depressive Disorder, Major, Depression in Remission
- Trial name
- NCT05111665
- Testing
- Mindfulness-based Cognitive Therapy (MBCT), Relaxation Group Therapy (RGT), Treatment as usual (TAU)
- Where
- Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Major Depressive Disorder
A Phase 3 Trial of DT120 for Major Depressive Disorder (Emerge)
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Emerge
- Trial name
- NCT06941844
- Testing
- DT120
- Where
- 22 sites in United States
- Volunteers
- 149 people
- Sponsor
- Definium Therapeutics US, Inc.
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