Clinical trials: Adult Depression
Depression, Suicidality
Assessing Improvements in Mood and Sleep Trial
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt).
- Conditions
- Depression, Suicidality, Sleep
- Trial name
- AIMS (NCT06639477)
- Testing
- Treatment As Usual, Active Condition, Active Comparator
- Where
- 3 sites in United States
- Volunteers
- 420 people
- Sponsor
- University of Pittsburgh
COVID-19
Effectiveness and Safety of Two Vitamin D3 Supplementation Regimens in Adults with Early-stage COVID-19
This study aimed to determine the effectiveness and safety of individualized vitamin D3 supplementation in adult patients with early-stage severe COVID-19.
- Trial name
- VDCOVID19ACUTE (NCT06585995)
- Testing
- vitamin D (cholecalciferol) supplementation
- Where
- Mexico
- Volunteers
- 216 people
- Sponsor
- Escuela Militar de Graduados de Sanidad, SEDENA
Depression, Major Depressive Disorder
Feasibility and Acceptability of a Healthy Nordic Diet Intervention in Depressed and Non-depressed Adults
In the future, we plan to conduct an 8-week diet intervention to investigate whether a healthy Nordic diet improves depression symptoms.
- Trial name
- NCT04731454
- Testing
- Control Diet (CD), Healthy Nordic Diet (ND)
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Anxiety Depression
Effectiveness and Safety of Probiotics in Relieving Anxiety and Depression
To evaluate the effectiveness and safety of probiotics in relieving anxiety and depression in adults, in comparison with placebo.
- Trial name
- NCT06629441
- Testing
- Probiotic group
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Taste Disorders
Gustatory Modulators Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy
Identify possible modulators for developing gustatory dysfunction among a sample of depressed Egyptian adults (age from 20 to 50 years old) under anti-depressants therapy ( for at least 3 months) using a questionnaire ( appendix)…
- Trial name
- NCT04923425
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Depressive Disorder, Major
A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy
The purpose of this study is to assess the dose-response relationship of 2 doses of JNJ-42847922 before interim analysis, and potentially 3 doses based on interim analysis results, compared to placebo as adjunctive therapy to an…
- Trial name
- NCT03227224
- Testing
- JNJ-42847922
- Where
- 101 sites in United States, Bulgaria and 6 more
- Volunteers
- 287 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder (MDD), Suicidal Ideation
Accelerated Intermittent Theta Burst Stimulation for Adolescent and Young Adult Depression With Elevated Suicide Risk
The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts.
- Trial name
- NCT07025720
- Testing
- TMS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, Davis
Psychosis, Bipolar and Related Disorders
A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults
Researchers aim to test a brief culturally-responsive young adult orientation program for community mental health services. They will conduct a 24-month randomized trial with 80 young adults from racial and ethnic minority groups…
- Conditions
- Psychosis, Bipolar and Related Disorders, Depressive Disorder
- Trial name
- NCT06508450
- Testing
- Just Do You, Component A, Component B
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- New York University
Bipolar Disorder, Affective Psychosis, Bipolar
Management of my Bipolarity Intervention in Bipolar Disorder Patients
The Management of my Bipolarity study aims to develop an educational intervention (MoB EI) on the combined use of technology and face to face education on the empowerment of ill health self-management skills in adults with…
- Conditions
- Bipolar Disorder, Affective Psychosis, Bipolar, Manic-Depressive Psychosis, Depression, Bipolar
- Trial name
- MoB (NCT04643210)
- Testing
- F2F MoB EI, MoB DP
- Where
- Cyprus
- Volunteers
- 80 people
- Sponsor
- Cyprus University of Technology
MAjor Depressive Disorder
The Experience of Older Adults Facing Depression for the First Time in Old Age
Analysis of recent studies show that researchers find it hard to distinguish between Late Onset Depression, a first diagnosed major depressive episode which occurs at old age, and Early Onset Depression, a depressive episode at…
- Trial name
- NCT03009448
- Testing
- Interview
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Shalvata Mental Health Center
Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) in Young Individuals with Major Depressive Disorder: a Literature Review and Feasibility Study
Objectives: (1) To assess the therapeutic effects of tDCS on improving depressive symptoms in young individuals with Major Depressive Disorder (MDD), relative to sham stimulation ; and (2) to evaluate the tolerability, and…
- Trial name
- NCT06518642
- Testing
- Sooma tDCS portable device - active stimulation
- Where
- Hong Kong
- Volunteers
- 8 people
- Sponsor
- The University of Hong Kong
Stress, Anxiety
An ISO Principle-Based Music Intervention for Reducing Stress, Anxiety, and Depression
This study aims to evaluate the effectiveness of a music-based intervention, guided by the ISO principle, in reducing stress, anxiety and depression induced by work, family or others among adults.
- Conditions
- Stress, Anxiety, Depression in Adults
- Trial name
- ISO4SAD (NCT07055061)
- Testing
- ISO Principle Music Intervention, DUL Principle Music Intervention, ISO Principle Music Intervention with Waiting-list
- Where
- 2 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride Extended-Release Tablets Using 11C-CFT Positron Emission Tomography (PET)
This study was a single-arm, non-randomized, open-label clinical study to assess dopamine transporter occupancy in the brain of healthy adults using 11C-CFT positron emission tomography (PET)
- Trial name
- NCT05905120
- Testing
- Toludivenlafaxine hydrochloride sustained-release tablets
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Vortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder (MDD)
The purpose of this study is to evaluate the efficacy of vortioxetine (5, 10, and 20 mg) versus placebo during the first 28 weeks of the 32-week double-blind treatment period in the prevention of relapse in participants with MDD…
- Trial name
- NCT02371980
- Testing
- Vortioxetine
- Where
- 79 sites in United States
- Volunteers
- 1,106 people
- Sponsor
- Takeda
Delusions, Depression
Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder
Psychological studies have shown that individuals tend to attribute causes of positive and negative events differently. Specifically, individuals hold an internalising or externalising bias of attribution which, in the case of…
- Trial name
- NCT03449394
- Testing
- Metacognitive Training
- Where
- Hong Kong
- Volunteers
- 113 people
- Sponsor
- Chinese University of Hong Kong
Dementia, Mild, Mild Cognitive Impairment
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
The purpose of this study is to test the adapted protocol, CAPABLE Family which builds upon the evidenced based CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early…
- Conditions
- Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive
- Trial name
- NCT05187117
- Testing
- CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Major Depressive Disorder
Heart Rate Variability in Depression
The purpose of this study is to understand if there is a relationship between the way that emotions are regulated by the brain and the way that heart rate is regulated by the brain.
- Trial name
- NCT02525978
- Testing
- Video Task, Imaginal Task
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Emory University
Mild Cognitive Impairment (MCI), Depressive Symptoms
rTMS Combined With Aerobic Exercise for Older Adults With Mild Cognitive Impairment and Comorbid Depression
This study aims to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) and aerobic exercise on cognitive function and mental health in older adults with mild cognitive impairment (MCI) and comorbid…
- Trial name
- NCT07652775
- Testing
- Repetitive Transcranial Magnetic Stimulation, Aerobic Exercise
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Cheng-Hsin General Hospital
Young Adult
The Effect of Smartphone Addiction on Physical Activity and Depression in University Students
This study was planned considering that young people with smartphone addiction are depressed and their physical activity is significantly reduced.
- Trial name
- NCT04606277
- Testing
- Smartphone addiction scale, physical activity scale and depression questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Major Depressive Disorder
Assessment in Work Productivity and the Relationship With Cognitive Symptoms in Patients With MDD Taking Vortioxetine
The purpose of the study is to describe the association/correlation between change in patient-reported cognitive symptoms and work productivity in gainfully employed patients receiving vortioxetine for a Major Depressive Episode…
- Trial name
- AtWoRC (NCT02332954)
- Testing
- vortioxetine
- Where
- 26 sites in Canada
- Volunteers
- 226 people
- Sponsor
- Lundbeck Canada Inc.
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