Clinical trials: Adult Depression
Major Depressive Disorder (MDD)
A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression
In this study, researchers will learn more about a study drug called DT-101 in participants with Major Depressive Disorder (MDD), a form of depression.
- Trial name
- AERON-1 (NCT07610473)
- Testing
- DT-101
- Where
- 23 sites in United States
- Volunteers
- 118 people
- Sponsor
- Draig Therapeutics Ltd
Depressive Disorder, Treatment-Resistant
A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
The purpose of this study is to evaluate the efficacy of switching adult participants with treatment-resistant depression (TRD) from a prior antidepressant treatment (to which they have not responded) to flexibly dosed intranasal…
- Trial name
- NCT03434041
- Testing
- Esketamine 56 mg, Esketamine 84 mg, Duloxetine (Oral Antidepressant)
- Where
- 30 sites in United States, China
- Volunteers
- 252 people
- Sponsor
- Janssen Research & Development, LLC
Depressive Disorder, Major
A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder
The study will evaluate the efficacy, safety, and tolerability of 450 milligrams (mg) of Rapastinel, compared to placebo in adult patients with major depressive disorder (MDD) who are at imminent risk of suicide.
- Trial name
- NCT03352453
- Testing
- Rapastinel
- Where
- 17 sites in United States
- Volunteers
- 138 people
- Sponsor
- Naurex, Inc, an affiliate of Allergan plc
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas
Depressive Disorder
A Fifty-two-week Study to Evaluate the Safety of Saredutant in Adult and Elderly Patients With Depression
The purpose of the study is to evaluate the long-term safety of saredutant (or SR48968C) in adult and elderly patients with depression.The primary objective is to evaluate the long-term safety and tolerability of a 100 mg dose of…
- Trial name
- NCT00250653
- Testing
- Saredutant succinate (SR48968C)
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- Sanofi
Major Depressive Disorder, Loneliness
Treating Loneliness In The Older Adult With Depression With tDCS
High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited.
- Trial name
- NCT06658795
- Testing
- Transcranial direct current stimulation (tDCS) on the Left DLPFC, Transcranial direct current stimulation (tDCS) on the right VLPFC
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Frail Elderly Syndrome
A Machine Learning Algorithm to Predict Health Clinical Situations in Primary Healthcare for Frail Older Adults.
Introduction: We developed a machine learning algorithm to predict the risk of emergency hospitalization within the new 7 to 14 days with a good predictive performance (AUC=0.85).
- Trial name
- NCT06013709
- Testing
- PRESAE CARE
- Volunteers
- 1,478 people
- Sponsor
- Presage
Depression
Primary Care Based Depression Prevention for Adolescents/Young Adults/Young Adults and Young Adults
The purpose of this research is to evaluate the feasibility of an interview between an adolescent / young adult and a PCP (Primary Care Physician).
- Trial name
- CATCH-IT (NCT00145912)
- Testing
- MI + CATCH-IT Internet Site, BA (brief advice) + CATCH-IT Internet site
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Chicago
Cardiac Surgery, Older Adults
Behavioral Activation and Medication Optimization In Older Adults Undergoing Cardiac Procedures
This Hybrid 1 Study will test the effectiveness of a bundled intervention comprised of behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing cardiac surgery…
- Conditions
- Cardiac Surgery, Older Adults, Depression, Anxiety
- Trial name
- NCT05575128
- Testing
- Behavioral activation, Medication optimzation, Care as usual
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Washington University School of Medicine
Exercise, Physical Fitness
Internet-based Physical Activities Randomized Controlled Trial in Mild/Moderate Depression Participants: SONRIE Project
The goal of this randomized controlled trial is to determine the effect of an intervention program with physical activity for 12 weeks on depression, social and emotional well-being and quality of life and health in adults with…
- Conditions
- Exercise, Physical Fitness, Depression, Adult ALL
- Trial name
- SONRIE (NCT05849792)
- Testing
- Exercise and psychological intervention
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- University of Cadiz
Stress, Anxiety
Single-Session Web-Based Training in Self-Compassion
Two-arm, parallel group randomized clinical trial conducted via Mturk comparing a single-session web-based intervention called Compassionate Care versus a control intervention (nature videos with relaxing music) for adults with…
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT05715034
- Testing
- Compassionate Care, Relaxing with Nature
- Where
- United States
- Volunteers
- 365 people, healthy volunteers welcome
- Sponsor
- Yale University
Depression
Combination Lexapro and Massage for Treatment of Depression in Older Adults
Depression is a common and disabling condition which represents a substantial public health concern, especially with the aging of the population in general.
- Trial name
- NCT00643162
- Testing
- Lexapro, Light touch, Massage
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Cedars-Sinai Medical Center
Major Depressive Disorder
Pharmacogenomics for Antidepressant Guidance and Education 1 (PAGE-1_AG1)
One-third or more of individuals treated for major depressive disorder (MDD) do not experience remission of symptoms despite at least two adequate antidepressant trials.
- Trial name
- PAGE-1_AG1 (NCT01426516)
- Testing
- Genecept Assay
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Genomind, LLC
Major Depressive Disorder
Study Evaluating DVS-233 SR And Venlafaxine ER In Adult Outpatients With Major Depressive Disorder
To compare the antidepressant efficacy and safety of DVS-233 SR with those of placebo in adult outpatients with MDD.
- Trial name
- NCT00090649
- Testing
- DVS-233 SR
- Volunteers
- 369 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Heart Failure, Depression
Problem-solving to Improve Depressive Symptoms and Self- Care Among Recently Hospitalized Adults With Heart Failure
The purpose of this study is to examine the feasibility of providing a problem-solving therapy-based intervention to improve both depressive symptoms and heart failure self-care specifically after hospital discharge.
- Trial name
- NCT03606304
- Testing
- Problem-solving therapy
- Sponsor
- University of Rochester
Major Depressive Disorder (MDD)
NQ TMS for MDD Therapy Using 1 Day x 3 Sessions Protocol for Adult Patient
Transcranial Magnetic Stimulation (TMS) Therapy is a non-invasive procedure that uses magnetic pulses to stimulate the cortex (brain) to treat Major Depressive Disorder (MDD).
- Trial name
- NCT06772987
- Testing
- Accelerated rTMS treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NeuroQore Inc.
Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure
Closed-Loop O2 Use During High Flow Oxygen Treatment of Critical Care Adult Patients (CLOUDHFOT)
High flow nasal oxygen therapy (HFNO) is an established modality in the supportive treatment of patients suffering from acute hypoxemic respiratory failure.
- Conditions
- Acute Hypoxemic Respiratory Failure, Acute Hypercapnic Respiratory Failure, Respiratory Depression, Respiratory Failure
- Trial name
- CLOUDHFOT (NCT06374589)
- Testing
- Closed-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Dementia, Depression
3D Team Care for Cognitively Vulnerable Older Adults
This study addresses how to achieve better outcomes for cognitively vulnerable community-dwelling older adults and their families.
- Conditions
- Dementia, Depression, Delirium
- Trial name
- NCT02945085
- Testing
- Home Based Care Team, Telephone Based Care Team
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- UConn Health
Depression
Treatment of Depression in Adults
This study will determine how certain features of depressed individuals affect their responses to depression treatment.
- Trial name
- NCT00073697
- Testing
- Escitalopram, Interpersonal Psychotherapy, Escitalopram plus IPT
- Where
- 2 sites in United States, Italy
- Volunteers
- 290 people
- Sponsor
- University of Pittsburgh
Anxiety, Depression
Effects of a High EPA Multinutrient Supplement on Negative Affect in Young Adults.
This is a 12-week-long, randomised, double-blind, placebo-controlled trial exploring the efficacy of a high-EPA multinutrient supplement in the management of sub-clinical anxiety and depression.
- Trial name
- NutriMOOD (NCT04844034)
- Testing
- High-EPA multinutrient supplement.
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
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