Clinical trials: Adult Depression
Physical Activity, Psychosocial Stressors
Improving Physical and Psychosocial Well-being of African American Older Adults
The proposed research effort will: The purpose of this study is as follows: 1. Test the feasibility and acceptability of an eight-week community-based exercise program among AA older adults living in rural areas. 2.
- Trial name
- NCT03716037
- Testing
- Physical Activity for Life (PAL)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Post Traumatic Stress Disorder, Depressive Symptoms
The Feasibility of Cognitive Process Therapy in Earthquake-affected Population With Mental Health Problems in Türkiye
The aim of the study is to test the pilot effectiveness of Cognitive Processing Therapy (CPT) in decreasing psychological distress and post-traumatic stress disorder (PTSD) symptoms and increasing well-being in earthquake…
- Conditions
- Post Traumatic Stress Disorder, Depressive Symptoms, Well-Being, Psychological, Anxiety Disorders and Symptoms
- Trial name
- NCT06136481
- Testing
- Cognitive Processing Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Koç University
Covid19, Mental Health
Mental Health Among Patients, Providers, and Staff During the COVID-19 Era
The Mental Health Among Patients, Providers, and Staff (MHAPPS) Study is designed to study how the COVID-19 pandemic has affected mental health and wellbeing, and how to support mental health while minimizing the burden on the…
- Trial name
- MHAPPS (NCT04700137)
- Testing
- Caring Contacts Plus Introductory Phone Call (CC+), Caring Contacts without an introductory phone call (CC)
- Where
- United States
- Volunteers
- 666 people
- Sponsor
- St. Luke's Health System, Boise, Idaho
Depression NOS
Feasibility of Empowerment Group Therapy on Ukrainian Adult Outpatients
This single-arm pilot study aims to explore the feasibility and acceptability of the culturally adapted, Ukrainian version of the Empowerment Group Therapy (Wiechers, 2023) manual and accompanying workbook for the Ukrainian…
- Trial name
- NCT07048990
- Testing
- Empowerment Group Therapy
- Where
- Ukraine
- Volunteers
- 55 people
- Sponsor
- Charite University, Berlin, Germany
Depressive Symptoms, Anxiety
Digital Mental Health and Wellness Intervention for Adults: A Randomized Control Trial of COMET
The investigators are evaluating the acceptability and effectiveness of brief online wellness modules. Participants will be randomly assigned to the intervention condition, an active control condition, or a wait-list control…
- Trial name
- COMET (NCT04586192)
- Testing
- Common Elements Toolbox- Adult version (COMET-A), Self-awareness Control
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Depression, Anxiety
A Randomized Controlled Trial of a VR Social Music-Movement Exergame for Depression and Anxiety in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of a virtual reality (VR) music-movement exergaming intervention for improving social connectedness and psychological well-being among young adults.
- Trial name
- VR-MOVE (NCT07482852)
- Testing
- VR social musical exergame, VR solo musical exergame, Waitlist control
- Volunteers
- 130 people
- Sponsor
- Hunan University of Traditional Chinese Medicine
Depression, Stage I Breast Cancer
Factors Affecting Weight Gain in Women Receiving Adjuvant Chemotherapy for Breast Cancer
RATIONALE: Chemotherapy may affect various factors that can lead to weight gain. PURPOSE: Clinical trial to evaluate factors that may affect weight gain in women receiving adjuvant chemotherapy for stage I, stage II, or stage…
- Conditions
- Depression, Stage I Breast Cancer, Stage IIIA Breast Cancer, Nutrition
- Trial name
- NCT00019643
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Loneliness, Cognitive Impairment
The Presence of Humanoid Robot With Older Adults at Homes
Background Older adults experience significant physical, cognitive and environmental losses in their later life. Self-supported 'aging-in-place' has benefits for mental health and the quality of life for older people.
- Conditions
- Loneliness, Cognitive Impairment, Depression, Self Efficacy
- Trial name
- NCT06487611
- Testing
- A humanoid social robot
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression, Depressive Disorder
A Single Group Study of Empower@Home-an Internet Cognitive Behavioral Therapy Intervention
This is a single group study of a novel internet-based cognitive behavioral therapy program for older adults with elevated depressive symptoms.
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT05384704
- Testing
- Empower@Home
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Michigan
Frail Elderly, Cognitive Impairment
A Community Health Worker Program to Support Rural Older Adults
This study will investigate an intervention delivered by community health workers for older adults with signs of cognitive impairment, mobility loss, and depression in the rural primary care setting.
- Conditions
- Frail Elderly, Cognitive Impairment, Mobility Limitation, Depressive Symptoms
- Trial name
- NCT03843333
- Testing
- Tai Ji Quan: Moving for Better Balance, Behavioral Activation, Resource Navigation
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- University of Vermont
Major Depressive Disorder
Trial to Evaluate the Effectiveness of a Digital Therapeutics in Adults Diagnosed With Major Depressive Disorder
This study compares the effectiveness of 2 digital therapeutics in adult participants diagnosed with major depressive disorder (MDD) who are on antidepressant therapy (ADT) monotherapy for the treatment of depression.
- Trial name
- MIRAI (NCT04770285)
- Testing
- CT-152 - Digital Therapeutic
- Where
- United States
- Volunteers
- 386 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Depressive Disorder, Major, Anhedonia
A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with…
- Trial name
- VENTURA-1 (NCT05455684)
- Testing
- Aticaprant
- Where
- 120 sites in United States, Argentina and 11 more
- Volunteers
- 513 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder, Cognitive Dysfunction
Musical Attention Control and Executive Function Training for Adults With MDD
The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques.
- Conditions
- Major Depressive Disorder, Cognitive Dysfunction, Suicide
- Trial name
- NCT05694156
- Testing
- Music-based cognitive training
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
PTSD, Depression
Evaluation of the Efficacy of Internal Family Systems (IFS) Therapy
Study examining the effectiveness of 16 weeks of Internal Family Systems (IFS) therapy for adults with posttraumatic stress disorder (PTSD).
- Trial name
- IFS (NCT05155930)
- Testing
- Internal Family Systems (IFS)
- Volunteers
- 17 people
- Sponsor
- Justice Resource Institute
Mild Cognitive Impairment, Depressive Symptoms
HEPPI: Efficacy of a Cognitive-Emotional Intervention for Homebound Older Adults
The main goal of this research is to assess the efficacy of a 10-week home-delivered cognitive-emotional intervention program for homebound older adults presenting Mild Cognitive Impairment (MCI) and depressive and/or anxiety…
- Conditions
- Mild Cognitive Impairment, Depressive Symptoms, Anxiety State
- Trial name
- HEPPI (NCT05499767)
- Testing
- HEPPI
- Where
- Portugal
- Volunteers
- 199 people
- Sponsor
- University of Coimbra
Major Depressive Disorder
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder
This is a Phase 2B clinical study evaluating the effectiveness and safety of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder.
- Trial name
- NCT06254612
- Testing
- SP-624
- Where
- 50 sites in United States
- Volunteers
- 497 people
- Sponsor
- Sirtsei Pharmaceuticals, Inc.
Depression, Anxiety
The Effects of Wild Blueberries on Depressive Symptoms in Young Adults
This study aims to investigate the effects of a 6-week dietary intervention of 22 g freeze-dried whole wild blueberry powder. The outcomes include measures of depression, anxiety, anhedonia, cognitive function, and biomarkers of…
- Conditions
- Depression, Anxiety, Anhedonia
- Trial name
- BluMood (NCT04647019)
- Testing
- Wild blueberry powder
- Where
- United Kingdom
- Volunteers
- 62 people
- Sponsor
- University of Reading
Major Depressive Disorder
Vilazodone for Treatment of Geriatric Depression
The purpose of this study is to examine the effects of vilazodone for the treatment of depression in older adults.
- Trial name
- NCT01608295
- Testing
- Vilazodone; Viibryd, Paroxetine; Paxil
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Schizophrenia, Schizoaffective Disorder
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
This study will evaluate the efficacy of valbenazine on clinician- and patient-reported outcomes in participants with TD while receiving or after stopping a VMAT2 inhibitor.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT07105111
- Testing
- Valbenazine
- Where
- 19 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
Depression, Cancer
Evaluating Procedures for a Study of the AYA Survivors Coping and Emotional Needs Toolkit
The investigators developed a digital intervention that aims to help adolescent and young adult cancer survivors (AYAs) manage symptoms of depression.
- Conditions
- Depression, Cancer, Adolescent, Young Adult
- Trial name
- ASCENT (NCT06420193)
- Testing
- AYA Survivors Coping and Emotional Needs Toolkit (ASCENT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- East Carolina University
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