Clinical trials: Adult Depression
Anxiety, Depression
Growth, Empowerment, and Mindfulness (GEM): A Mindfulness-based Intervention to Address Mental Health in Young Adults With Early Life Adversity
The goal of this clinical trial (single-arm feasibility study) is to examine the feasibility, acceptability, and preliminary efficacy of a mindfulness-based, app-delivered intervention to address mental health and emotion…
- Trial name
- NCT07546799
- Testing
- Growth, Empowerment, and Mindfulness (GEM)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brown University
Treatment-resistant Depression (TRD)
ALTO-207 in Adults With Treatment-resistant Depression (TRD)
The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD.
- Trial name
- NCT07553637
- Testing
- ALTO-207
- Where
- 63 sites in United States, United Kingdom
- Volunteers
- 178 people
- Sponsor
- Alto Neuroscience
Anxiety, Depressive Symptoms
A Single-Session Intervention for Adolescents and Young Adults With Internalizing Problems
With the increasing number of adolescents and young adults (AYA) experiencing depression and anxiety, paired with the lack of time, access, and funding towards social services, AYA need a mental health intervention that is…
- Trial name
- NCT05826392
- Testing
- Adolescent/Young Adult Self-Administered Web-Based Single-Session Intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Major Depressive Disorder With Anxious Distress
A Study of JNJ-61393215 in the Treatment of Depression
The purpose of this study is to evaluate the efficacy of JNJ-61393215 as adjunctive treatment compared to adjunctive placebo, as assessed by the change from baseline to week 6 on a 17-item Hamilton Depression Rating Scale…
- Trial name
- NCT04080752
- Testing
- JNJ-61393215
- Where
- 35 sites in United States, Moldova and 3 more
- Volunteers
- 222 people
- Sponsor
- Janssen Research & Development, LLC
Treatment Outcome
Vortioxetine (Lu AA21004) 10 and 20 mg for Treatment of Major Depressive Disorder With Sexual Dysfunction
The purpose of this study is to evaluate the effects of Vortioxetine (Lu AA21004), once daily (QD), compared with escitalopram on sexual functioning.
- Trial name
- NCT01364649
- Testing
- Vortioxetine, Escitalopram
- Where
- 62 sites in United States, Canada
- Volunteers
- 447 people
- Sponsor
- Takeda
Major Depressive Disorder
Trial of Levomilnacipran in Geriatric Depression
The purpose of this study is to examine the effects of levomilnacipran (FETZIMA) compared to placebo for the treatment of depression in older adults.
- Trial name
- LMIL (NCT02466958)
- Testing
- levomilnacipran
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of California, Los Angeles
Anxiety, Depression
Implementation of WHO's Doing What Matters in Times of Stress in Dutch Small and Medium-sized Enterprises (SMEs)
The goal of this cluster randomized controlled trial is to explore if mental health in Dutch small and medium-sized enterprises (SMEs) can be improved by the World Health Organization's online program Doing What Matters in Times…
- Conditions
- Anxiety, Depression, Psychological Distress
- Trial name
- NCT06979089
- Testing
- Doing What Matters in Times of Stress
- Where
- Netherlands
- Volunteers
- 518 people
- Sponsor
- VU University of Amsterdam
Cancer
E-MOSAIC Electronic Tool to Monitor Symptoms
RATIONALE: A hand held electronic tool used to monitor symptoms and assess quality of life may improve communication between patients and their doctors and improve the ability to plan treatment for patients with advanced cancer…
- Trial name
- NCT00477919
- Where
- 7 sites in Switzerland
- Volunteers
- 264 people
- Sponsor
- Swiss Cancer Institute
Major Depressive Disorder
Creatine Augmentation in Veterans With SSRI-Resistant Major Depression
The purpose of this study is to determine whether creatine will be helpful as an adjunctive treatment for treatment-resistant major depressive disorder (MDD) in female and male Veterans.
- Trial name
- NCT01175616
- Testing
- Creatine
- Sponsor
- University of Utah
Systolic Blood Pressure, Blood Pressure
IMST for Dementia Risk Reduction
Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and…
- Conditions
- Systolic Blood Pressure, Blood Pressure, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07349706
- Testing
- Inspiratory Muscle Strength Training High-Resistance, Inspiratory Muscle Strength Training Low-Resistance
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Florida State University
Insomnia, Depression
The Sleep Course: An Online Sleep Intervention for Adults With Self-reported Sleep Difficulties
This study evaluates an internet-delivered cognitive behavioural therapy for insomnia (ICBTi) intervention, known as the Sleep Course, within a routine online therapy clinic (the Online Therapy Unit).
- Conditions
- Insomnia, Depression, Anxiety
- Trial name
- NCT06745349
- Testing
- Sleep Course
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Regina
Depressive Symptoms
Effects of High-Intensity Interval Training on Depressive Symptoms in Hong Kong Older Adults
Depression in later life is a common health problem in aging societies. It is associated with poor quality of life, and increased risks of morbidity and mortality.
- Trial name
- NCT06014294
- Testing
- HIIT, Baduanjin, Workshop
- Where
- Hong Kong
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Depression
Dance Movement Therapy in the Treatment of Depressed Patients: A Randomised Controlled Trial
This multi-centre research investigates the effects of dance movement therapy (DMT) on participants diagnosed with depression. In total, 109 persons participated in the study in various locations in Finland.
- Trial name
- NCT04421651
- Testing
- Dance Movement Therapy group
- Volunteers
- 109 people
- Sponsor
- University of Jyvaskyla
Major Depressive Disorder, Dysthymic Disorder
Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults
The goal of this open-administration treatment study of citalopram (or duloxetine) is to evaluate the effect of antidepressant medication on treating the syndrome of "frailty" in older adults with depressive symptoms.
- Conditions
- Major Depressive Disorder, Dysthymic Disorder, Depressive Disorder, NOS
- Trial name
- NCT01973283
- Testing
- Antidepressant Medication
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- New York State Psychiatric Institute
Carbon Monoxide, Pain Perception, Sensory Thresholds, Anxiety, Depression, Tobacco Smoking
Effects of CO Level on Pain, Sensory Function, and Subjective Health
Carbon monoxide (CO) is a colorless and odorless gas that can enter the human body through environmental exposure and especially tobacco use.
- Trial name
- NCT07571941
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Major Depressive Disorder With Suicidal Ideation With Intent
Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent
Study of efficacy and safety of MIJ821 in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder (MDD) in subjects who have suicidal ideation with intent
- Trial name
- NCT04722666
- Testing
- MIJ821 Intravenous Injection
- Where
- 39 sites in United States, Argentina and 12 more
- Volunteers
- 199 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Low Back Pain
MBM and taVNS for Low Back Pain and Depressive Symptoms
This two-arm randomized controlled trial aims to test the preliminary effect of home-based mindfulness-based meditation and transcutaneous auricular vagus nerve stimulation on managing pain and depressive symptoms among…
- Trial name
- NCT07415941
- Testing
- MBM, VNSM
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Florida State University
Depressive Symptoms Mild to Moderate in Severity
A Pilot Study of Synbiotics in Adults With Depressive Symptoms
This study aims to explore the efficacy and safety of a synbiotic formula (MQU10) in improving mood and well-being in adults with mild to moderate depressive symptoms.
- Trial name
- NCT06905223
- Testing
- MQU10
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- GenieBiome Limited
Sleep Deprivation, Depression
Work Hour Reductions, Medical Errors, and Intern Well-Being at Providence St. Vincent Medical Center Intensive Care Unit
The purpose of this study is to determine whether reducing intern work hours and eliminating extended shifts in the intensive care unit will reduce prescribing errors and improve intern well-being.
- Trial name
- NCT00996320
- Testing
- Reduced work hour schedule
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Providence Health & Services
Depression and Quality of Life, Sexual Violence
Empowerment Self Defense Program for Adult Native Women Survivors of Sexual Violence
The purpose of this study is to culturally adapt and evaluate an empowerment self-defense (ESD) program (i.e., IMpower) for AI/AN women who have experienced SV in their lifetime and currently experiencing moderate to severe…
- Conditions
- Depression and Quality of Life, Sexual Violence, PTSD, Suicidal Ideation
- Trial name
- ESD (NCT07712796)
- Testing
- Empowerment self-defense training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan
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