Clinical trials: Adult Depression
Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted
Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder.
- Conditions
- Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched
- Trial name
- Creyos-MD (NCT06780917)
- Where
- 3 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
A Study of LY2216684 in Participants With Major Depression Disorder
The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily in the adjunctive treatment with an Selective Serotonin Reuptake Inhibitors (SSRI) for up to…
- Trial name
- NCT01370499
- Testing
- LY2216684, SSRI
- Where
- 9 sites in Japan
- Volunteers
- 288 people
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder, Major Depressive Episode
Glabellar Botulinum Toxin Injections for the Treatment of Geriatric Depression
The effectiveness of glabellar injection of botulinum toxin type A (BTA) in treating depression has not yet been investigated in elderly patients.
- Conditions
- Major Depressive Disorder, Major Depressive Episode, Treatment Resistant Depression
- Trial name
- BOTDEP (NCT03833063)
- Testing
- botulinum toxin A
- Sponsor
- Helse Stavanger HF
Prolonged Grief Symptoms
Internet-based Self-help After Spousal Bereavement or Divorce
The purpose of this study is to evaluate the efficacy of an internet-based self-help intervention for older adults with prolonged grief symptoms after spousal bereavement or separation/divorce.
- Trial name
- LIVIA (NCT02900534)
- Testing
- Internet-based self-help
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- University of Bern
Depressive Disorder
PB-18 Probiotic for Mild to Moderate Depression
The goal of this clinical trial is to learn if Bifidobacterium PB-18 can treat mild to moderate depressive disorder in adults aged 18 to 65 years who are not taking antidepressants or other psychotropic medications during the…
- Trial name
- NCT07562516
- Testing
- Bifidobacterium
- Volunteers
- 88 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression
Adult Depression and Integrative Medical Care
The goal of this quasi-experimental study is to learn if integrative medical care works to treat depression in adults and compare it to usual medical care.
- Trial name
- NCT06915207
- Testing
- Counselling, behavioural, nutrition
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- University of Saskatchewan
Major Depressive Disorder
Virtual Mindfulness Training for Adults With History of Depression
Mindfulness Based Cognitive Therapy (MBCT) has shown to be an effective method of preventing relapse of an episode Major Depressive Disorder (MDD).
- Trial name
- NCT05347719
- Testing
- MBCT Intervention
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Clemson University
Suicide, Attempted, Suicidal Ideation
WellPATH-PREVENT: A Mobile Intervention for Middle-Aged and Older Adults Hospitalized for Suicidal Ideation or Attempt
The goal of this project is to test whether WellPATH-PREVENT (a novel, mobile psychosocial intervention) improves a specific aspect of emotion regulation, i.e., cognitive reappraisal ability, and reduces suicide risk in…
- Conditions
- Suicide, Attempted, Suicidal Ideation, Depression
- Trial name
- NCT05183230
- Testing
- WellPATH-PREVENT, Optimized WellPATH-PREVENT
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- Weill Medical College of Cornell University
Depression
RCT of Adjunctive Curcumin and the Meru Health Program
This is a randomized controlled trial (RCT) to compare the Meru Health Program plus adjunctive curcumin (MHP-CUR) versus Meru Health Program only (MHP-ONLY) for adults with depression.
- Trial name
- NCT04744545
- Testing
- Meru Health Program, Curcumin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meru Health, Inc.
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Emotional Distress, Anxiety
Conceptualization and Scale Development of Excessive Emotional Behaviors
Emotional disorders, including anxiety and depression, represent a major global health burden and are increasingly conceptualized within a transdiagnostic framework.
- Conditions
- Emotional Distress, Anxiety, Depression Anxiety Disorder
- Trial name
- NCT07558772
- Where
- China
- Volunteers
- 637 people, healthy volunteers welcome
- Sponsor
- Xinghua Liu
Major Depressive Disorder (MDD
Single Dose Study to Evaluate Dose-proportionality of Vortioxetine Hemihydrobromide Orally Disintegrating Tablets
An open label, randomized, three-period, three-treatment, six-sequence, crossover, balanced, single dose, dose proportionality study.
- Trial name
- NCT05416762
- Testing
- Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 5mg, Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 10mg, Vortioxetine Hemihydrobromide Orally Disintegrating Tablets 20mg
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seasons Biotechnology (Taizhou) Co., Ltd.
LLM-based AI Dialogue Bot, Depression
Young People Aged 18-25 With Depression or Anxiety Mood Participate in an LLM-based Digital Dialogue Intervention Study
This study is a 28-day randomized controlled trial (RCT). Residents were randomly assigned to an intervention group or a waiting group according to the order in which they were successfully contacted by the staff, and each user…
- Conditions
- LLM-based AI Dialogue Bot, Depression, Anxiety
- Trial name
- NCT06346496
- Testing
- Douyin Xinqing AI dialog bot, Douyin Xinqing AI dialog bot for delayed intervention
- Where
- China
- Volunteers
- 657 people, healthy volunteers welcome
- Sponsor
- Institute of Psychology, Chinese Academy of Sciences
General Mental Health and Well-Being, Mental Disorders
PREWELL Digital Well-being Promotion Intervention With the BitHabit App
Mental wellbeing is a major public health concern, and digital interventions have emerged as a scalable approach for promoting mental well-being and healthy lifestyle behaviors.
- Conditions
- General Mental Health and Well-Being, Mental Disorders, Common Mental Disorders (CMD)
- Trial name
- PREWELL (NCT07868146)
- Testing
- Digital wellbeing promoting intervention with the BitHabit app
- Where
- Finland
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Older Adults, Hearing Impairment
Effect of an Aural Rehabilitation Program in Hearing-impaired Older Adults
Hearing impairment in older adults is becoming a common health problem as the population ages. The impact of hearing impairment in older adults includes not only physical function and cognitive performance, but also depression…
- Conditions
- Older Adults, Hearing Impairment, Nursing
- Trial name
- NCT05083221
- Testing
- Hear-Talk-Activity audiological program
- Where
- Taiwan
- Volunteers
- 96 people
- Sponsor
- National Taiwan University Hospital
Geriatrics
Activities of Daily Living in Older Adults
In order to maintain independence and prevent disability, it is essential to identify associated factors and reduce functional loss due to concomitant diseases.
- Trial name
- NCT05398523
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Halic University
Quality of Life, Behavioral Symptoms
A Structured Qi-gong Program for Hospitalized Older Adults
The purpose of this study is to test the effects on a number of health outcomes and the feasibility of a structured program of qi-gong, a form of tai-chi which has been previously tested in older populations, in older…
- Conditions
- Quality of Life, Behavioral Symptoms, Patient Compliance
- Trial name
- NCT00944788
- Testing
- qi-gong
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Fundacio Salut i Envelliment UAB
Depression, Loneliness
Nature-Oriented Chatbots on Older Adults' Mental Health
This study aims to explore the influence of nature-oriented chatbots on the mental health of older adults residing alone. Leveraging the therapeutic potential of nature exposure and the interactive capabilities of chatbot…
- Conditions
- Depression, Loneliness, Happiness, Connection With Nature
- Trial name
- NCT06423027
- Testing
- Nature-Oriented Chatbots
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Older Adults, Depression
Educational and Cultural Engagement and Incidence of Health Adverse Events
This study evaluated if the social and cultural activities decrease the incidence of dementia and frailty conditions.
- Conditions
- Older Adults, Depression, Cognitive Decline
- Trial name
- NCT03987360
- Testing
- Observational
- Where
- Canada
- Volunteers
- 30,000 people
- Sponsor
- Jewish General Hospital
Chronic Pain, Depression
Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study
The goal of this clinical trial is to pilot a randomized controlled trial comparing an adaptation of mindfulness-based cognitive therapy to the health enhancement program for chronic pain and depression.
- Trial name
- NCT07118722
- Testing
- Quiet Focus, Health Enhancement Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
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