Clinical trials: Adult Depression
Major Depression, Post Traumatic Stress Disorder
Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults
Phase I safety and dose finding study of a standardized Ayahuasca analog (SM-001) in healthy adult volunteers
- Trial name
- NCT05894902
- Testing
- SM-001
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Advanced Integrative Medical Science Institute
Older Adults Institutionalized in Residential Homes
A Virtual Reality Program for Nursing Home Residents With Physical Disabilities
This project will evaluate how well the immersive virtual reality psychological program works in residential care homes and how it can be used in everyday practice.
- Trial name
- NCT07879677
- Testing
- Psychological intervention
- Volunteers
- 400 people
- Sponsor
- Tung Wah College
Anxiety Symptoms, Perceived Stress
The Effects of Probiotic Supplementation on State and Trait Stress, Anxiety, and Depression Symptoms in Stressed Adults
The goal of this randomized controlled trial is to learn if supplementation with the probiotic Lactobacillus reuteri DSM 17938 can reduce levels of trait and state perceived stress, anxiety, and depressive symptoms compared to a…
- Conditions
- Anxiety Symptoms, Perceived Stress, Depressive Symptoms
- Trial name
- NCT07216729
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Boulder
Intrinsic Capacity, Frailty
Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults
The ICOPE Brazil study aims to understand aging trajectories in Brazil, especially healthy aging trends based on intrinsic capacity, a collective of mental and physical capacities one may have to maintain their functional ability…
- Conditions
- Intrinsic Capacity, Frailty, Aging, Healthy Aging
- Trial name
- ICOPE-BR (NCT06968702)
- Volunteers
- 3,838 people
- Sponsor
- University of Sao Paulo
Pancreatic Tumor, Benign, Pancreatic Cancer, Adult
Association Between Chronic Psychological Stress and Disease Course Outcomes in Pancreatic Cancer
This is a prospective, observational cohort study (MIND-PANC) to explore the associations of chronic psychological stress with disease progression, treatment outcomes, and prognosis of pancreatic cancer.
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Cancer, Adult, Pancreatic Cancer Resectable
- Trial name
- MIND-PANC (NCT07529626)
- Where
- 3 sites in China
- Volunteers
- 320 people
- Sponsor
- Shanghai Zhongshan Hospital
Major Depressive Disorder Patients
Study to Evaluate Safety and Tolerability of FK949E in Patients With Major Depressive Disorder
The objective of the study was to evaluate the safety and plasma concentration changes of quetiapine after multiple oral administration of FK949E (extended-release formulation of quetiapine) in patients with major depressive…
- Trial name
- NCT01871974
- Testing
- FK949E
- Where
- 2 sites in Japan
- Volunteers
- 16 people
- Sponsor
- Astellas Pharma Inc
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Binge-Eating Disorder, Emotion Regulation
Profiling the Dynamic of Binge Eating Disorder (PRODY-BED)
The goal of this observational study is to explore if different and specific profiles can be identified in adults with binge eating disorder (BED) depending on their additional eating pathology, emotion regulation and executive…
- Conditions
- Binge-Eating Disorder, Emotion Regulation, Executive Dysfunction, Eating Behavior
- Trial name
- PRODY-BED (NCT05726721)
- Testing
- Treatment as usual, Psychotherapy
- Where
- 3 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Aarhus University Hospital
Anxiety Disorder, Depression
Stress Management Training in Patients Undergoing Radiation Therapy for Cancer
RATIONALE: Stress management techniques such as muscle relaxation, guided imagery, and abdominal breathing may improve quality of life and decrease emotional distress in patients who are undergoing radiation therapy for cancer.
- Conditions
- Anxiety Disorder, Depression, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00057733
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 12 sites in United States
- Sponsor
- University of South Florida
Diabetes Mellitus, Type 2, Depression
Assessing Adherence to Digital Health Technologies Among Hispanic/Latino Adults With or At Risk of Type 2 Diabetes:
In an effort to personalize medical care, novel approaches have been used to categorize sub-populations of patients with type 2 diabetes (T2D).
- Conditions
- Diabetes Mellitus, Type 2, Depression, Anxiety, Diet Habit
- Trial name
- NCT04820348
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Older Adults, Mental Health
The BE WITH Project: A Partially Nested Randomized Control Trial (PN-RCT)
The goal of this clinical trial is to learn if the BE WITH (Belonging through Empathy With Intentional Targeted Helping) innovation delivered to older adults improves their mental health.
- Conditions
- Older Adults, Mental Health, Depression, Loneliness
- Trial name
- BE_WITH (NCT07204444)
- Testing
- standardized and manualized warm calls from providers trained in the BE training, standardized and manualized warm calls from providers trained in the BE training + ASIST training
- Where
- United States
- Volunteers
- 671 people, healthy volunteers welcome
- Sponsor
- University of Florida
Major Depressive Disorder
Brain Connectivity and Response to Tai Chi in Geriatric Depression
The purpose of this study is to evaluate the effects after up to 1 year of supervised weekly Tai-Chi-Chi versus Health Education and Wellness classes on reduction of depressive symptoms and improvement in resilience, health…
- Trial name
- NCT02460666
- Testing
- Tai-Chi-Chih (TCC), Health Education and Wellness Classes (HEW)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of California, Los Angeles
Major Depressive Disorder
Cranial Electrotherapy Stimulation for the Treatment of Major Depressive Disorder in Adults
This study is designed to evaluate the safety and efficacy of the Fisher Wallace Stimulator FW-200 to deliver Cranial Electrotherapy Stimulation (CES) for the treatment of moderate to severe Major Depressive Disorder (MDD) in…
- Trial name
- CES-MDD (NCT05384041)
- Testing
- Fisher Wallace Cranial Electrotherapy Stimulator (Active Device)
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Fisher Wallace Laboratories
Depression, Anxiety
The Effect of Chinese Five-element Music
Depression and anxiety among the older adults is an issue that cannot be ignored at present. Compared to traditional pharmacological treatments and electroconvulsive therapy, non pharmacological treatments with fewer side…
- Trial name
- NCT06472154
- Testing
- Experimental, Control
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Depression
Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults
This study will evaluate the effectiveness of memantine in improving rehabilitation outcomes and preventing major depressive disorder in older adults who have been admitted to a rehabilitation hospital for a hip fracture or…
- Trial name
- NCT00183729
- Testing
- Memantine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Eric Lenze
Early Onset Alzheimer Disease, Mild Cognitive Impairment
Reference Database & Longitudinal Registry of the Normal and Pathological Aging Brain
Establishment of a BNA reference database for the Adult and Elderly Population. Hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between clinical…
- Conditions
- Early Onset Alzheimer Disease, Mild Cognitive Impairment, Depression, Aging
- Trial name
- (BNA™) (NCT02875496)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd
Depression, Anxiety
Voice Activated Personal Assistant for Depression Among Older Adults
Participants will use Amazon Alexa to test a new voice-assisted program for mental health management. The participant will use this program to help with goal setting, reminders, and various other services.
- Trial name
- NCT06114485
- Testing
- VIPA Treatment Program, Alexa with Guidebook
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Insomnia
Eszopiclone Co-Administered With Escitalopram for Insomnia in Elderly Adults With Major Depressive Disorder
Research has established the incidence of insomnia increases with age and the possible causes contributing to sleep problems in the elderly are still being explored and debated.
- Trial name
- NCT00813735
- Testing
- Eszopiclone, Escitalopram
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lehigh Center for Clinical Research
Depression, Mental Health Disorder
e-Mindfulness for Depression in Older Adults
This pilot study will test whether depression symptoms and cognitive functioning are impacted by internet-delivered mindfulness training following the principles of mindfulness meditation.
- Trial name
- MMW (NCT03922217)
- Testing
- Mindful My Way
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Major Depressive Disorder (MDD), Major Depressive Episode
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
The goal of this observational study is to learn about remote mental health monitoring technology for adults with treatment-resistant depression.
- Conditions
- Major Depressive Disorder (MDD), Major Depressive Episode, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT06732089
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
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