Clinical trials: Adult Depression
Anxiety, Depression
Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks"
The goal of this study is first to develop and adapt a digital low-intensity treatment, "VIBE in the Parks", for adolescents and young adults (AYA) who visit programming at the Chicago Park District.
- Trial name
- VIBE (NCT07539636)
- Testing
- "VIBE in the Parks", Digital Control
- Volunteers
- 268 people
- Sponsor
- University of Illinois Chicago
Mindfulness Based Cognitive Therapy, Depression
MBCT Intervention: Healthy Mind, Healthy Living
Depression among older Korean Americans are rising. Mindfulness-based cognitive therapy (MBCT) is an evidence-based intervention (EBI), effective for preventing depression relapse and reducing depressive symptoms.
- Conditions
- Mindfulness Based Cognitive Therapy, Depression, Sleep, Anxiety Depression
- Trial name
- HMHL (NCT05965349)
- Testing
- Healthy Mind, Healthy Living
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Psychosocial Functioning, Surgery
Building Resilience for Surgical Recovery
The goal of this clinical trial is to test problem solving therapy (PST) in older adults who are undergoing major surgery. The main question it aims to answer is: What is the feasibility and acceptability of delivering PST to…
- Conditions
- Psychosocial Functioning, Surgery, Older Adults, Physical Function
- Trial name
- BRSR (NCT06174701)
- Testing
- Problem Solving Therapy (PST), Enhanced Usual Care
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The University of Texas Health Science Center, Houston
Depressive Disorder, Bipolar Disorder
Effect of African Drumming in Mood Disorders
This pilot study evaluated whether participating in an African drumming activity for 45 minutes immediately improved mental well-being among 13 adults diagnosed with acute mood disorders who were attending a private mental health…
- Trial name
- NCT02675712
- Testing
- African drumming
- Volunteers
- 13 people
- Sponsor
- University of Stellenbosch
Major Depressive Episode
Validation Study: Mobile DSST on Cognition in Adults With MDD
Objectives The primary objective of this study is to determine the convergent validity of the mobile DSST application with the pencil and paper version of the DSST.
- Trial name
- NCT03999567
- Testing
- Pen and Paper Digit Symbol Substitution Test (DSST), Electronic Digit Symbol Substitution Test (DSST)- (a.k.a. Codebreaker)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Brain and Cognition Discovery Foundation
Depressive Disorder, Major
54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide
The purpose of the study is to evaluate the efficacy of intranasal esketamine 84 milligram (mg) compared with intranasal placebo in addition to comprehensive standard of care in reducing the symptoms of Major Depressive Disorder…
- Trial name
- Aspire I (NCT03039192)
- Testing
- Esketamine, Standard of Care
- Where
- 56 sites in United States, Bulgaria and 9 more
- Volunteers
- 226 people
- Sponsor
- Janssen Research & Development, LLC
Sleep Disturbance, Sleep
Sleep and Circadian Interventions for College Students at High Risk of Suicide
The purpose of this study is to examine the extent to which delivering sleep and circadian focused interventions in addition to evidenced based psychiatric care for depression and suicide risk may contribute to decreasing suicide…
- Conditions
- Sleep Disturbance, Sleep, Depression, Suicide
- Trial name
- REST-UP (NCT07346014)
- Testing
- Sleep Feedback + Psychoeducation, Transdiagnostic Sleep and Circadian Intervention + Bright Light (TSC+), Triple Chronotherapy (TCT+)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Pittsburgh
Caregivers, Stress
Comprehensive Support for Alzheimer's Disease Caregivers
The purpose of this study is to determine the effectiveness of a comprehensive counseling and support intervention for people who care for parents with Alzheimer's disease (AD) or other dementias on outcomes such as stress…
- Conditions
- Caregivers, Stress, Depression
- Trial name
- NCT00362284
- Testing
- NYUCI-AC
- Where
- 2 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depressed Mood, Young Adults
Heat and Mental Health - PART 2
The goal of this clinical trial is to learn how hot indoor temperatures affect mood in young adults with depression, with or without anxiety.
- Conditions
- Depressed Mood, Young Adults, Heat Stress, Sleep
- Trial name
- NCT07903896
- Testing
- Heat/Humidity Exposure Condition, Thermoneutral Condition
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Hartford Hospital
Anxiety Disorders, Depression
Internet-administrated Treatment of Anxiety Symptoms for Young Adults
The purpose of this study is to determine whether tailored internet-administrated CBT is a feasible approach in the treatment of anxiety symptoms and comorbid anxiety and depressive symptoms in a clinical setting.
- Trial name
- NOVA-IV (NCT01402258)
- Testing
- Tailored Internet-administrated CBT-Treatment
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Linkoeping University
Depressive Disorder, Major
A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Disorder (MDD)
The purpose of this study to evaluate the efficacy of SAGE-217 in the treatment of participants with MDD.
- Trial name
- NCT04442490
- Testing
- SAGE-217
- Where
- 39 sites in United States
- Volunteers
- 543 people
- Sponsor
- Biogen
Cancer Diagnosis, Non-Metastatic Neoplasm
PRISM for Depression and Anxiety in Young Adults With Cancer
This research study is being done to test the feasibility of an existing supportive program (PRISM) to address psychological symptoms (i.e., depressive and anxiety symptoms) that young adult participants diagnosed with cancer or…
- Conditions
- Cancer Diagnosis, Non-Metastatic Neoplasm, Anxiety, Anxiety Disorders
- Trial name
- PRISM (NCT06502483)
- Testing
- Promoting Resilience in Stress Management Program
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Dana-Farber Cancer Institute
Major Depressive Disorder, Anxiety
Safety and Effectiveness Study of BCI-540 Versus Placebo in the Treatment of Major Depressive Disorder With Concomitant Anxiety
The purpose of this study is to determine whether BCI-540 80 mg given once daily (q.d.) or three times daily (t.i.d.) is effective in the treatment of major depression with concomitant anxiety.
- Trial name
- NCT00621270
- Testing
- BCI-540
- Where
- 16 sites in Canada
- Volunteers
- 115 people
- Sponsor
- BrainCells Inc.
Depression, Depressive Symptoms
Effectiveness of Aquatic Exercises for Improving Mental and Physical Health in Adults.
Objective: To compare the effectiveness between aquatic exercises (water aerobics versus Watsu) versus control groups, for improving the outcomes of depression, anxiety, stress, sleep quality, functionality, cognition and quality…
- Conditions
- Depression, Depressive Symptoms, Anxiety
- Trial name
- AEforMH (NCT04100850)
- Testing
- Aquatic Exercises, Watsu
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Universidade Federal do vale do São Francisco
Depression, Hypertension
Community-based Approach to Lowering Stress Through Mindfulness
The goal of this clinical trial is to test a culturally adapted mindfulness-based stress reduction intervention in a community setting for African American adults with high blood pressure (hypertension) and depression.
- Trial name
- CALM-Chicago (NCT06987799)
- Testing
- Mindfulness-Based Stress Reduction (MBSR; CALM-Chicago Study)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Major Depressive Disorder, Post Traumatic Stress Disorder
ALTO-100 in MDD and/or PTSD
The goal of this study is to collect biologically based data for defining predictors and correlates of the effects of ALTO-100.
- Trial name
- NCT05117632
- Testing
- ALTO-100 PO tablet
- Where
- 23 sites in United States
- Volunteers
- 245 people
- Sponsor
- Alto Neuroscience
Post Traumatic Stress Disorder, Major Depressive Disorder
Antidepressant Response in Older Adults With Comorbid PTSD and MDD
In the Investigator's ongoing studies of Posttraumatic Stress Disorder (PTSD) in older adults, it has been found that older adults with PTSD frequently meet the criteria for comorbid Major Depressive Disorder (MDD).
- Trial name
- NCT04697693
- Testing
- Escitalopram, Duloxetine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute
Predictive Model
Development and Validation of a Prediction Model for Depression and Anxiety in Perioperative Elderly Adults
Anxiety and depression in later life are highly prevalent, often appear as comorbid disorders, and have many adverse consequences for both the individual and society.
- Trial name
- NCT05600504
- Testing
- no intervention
- Where
- China
- Volunteers
- 6,386 people
- Sponsor
- Chinese PLA General Hospital
Depressive Symptoms, Aging
ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
This randomized, cross-over, pilot study aims to compare preliminary impact of a standard dose of blueberry powder (24 g) vs a higher dose (48 g) on the bioavailability of flavonoids and inflammatory biomarkers in older adults…
- Trial name
- NCT05937165
- Testing
- Freeze-dried Blueberry Powder
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Mental Health, Vitamin D
Omega-3 Supplementation and Mental Health in College Students
This randomized, placebo-controlled double blinded study examined whether placebo, low- or high dose omega 3 fatty acid supplementation had associations with mental health symptoms and vitamin D status in college students aged…
- Trial name
- OMEGA-MH (NCT07391254)
- Testing
- Low dose Omega 3, High dose Omega 3
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
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