Clinical trials: Adult Depression
Major Depressive Disorder (MDD)
An 8 Week Depression Study In Adults Diagnosed With Major Depressive Disorder
A Placebo Controlled Study Evaluating Efficacy, Safety and Tolerability of Radafaxine in Patients with Major Depressive Disorder (MDD)
- Trial name
- NCT00057239
- Testing
- Radafaxine
- Where
- 29 sites in United States
- Volunteers
- 546 people
- Sponsor
- GlaxoSmithKline
Fractures in the Elderly
Post-operative Anxiety and Depression Among Older Adults Who Undergo Surgery for Fragility Fractures
Patients who present with falls and fractures can experience increased symptoms of depression and anxiety due to the trauma of falling, hospitalisation and surgery.
- Trial name
- FFAD (NCT06724484)
- Testing
- Surgical management of fracture, No intervention
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Southampton
Major Depressive Disorder, Post Traumatic Stress Disorder
Positive Processes and Transition to Health
The R61 will be an open trial to determine if Positive Processes and Transition to Health (PATH) engages the proposed targets: unproductive processing, avoidance, and reward deficits in a sample of 45 adults who have experienced…
- Trial name
- PATH (NCT04678232)
- Testing
- Positive Processes and Transition to Health (PATH)
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Case Western Reserve University
Major Depressive Disorder
ALTO-300 in Depression (ALTO-300-004)
The purpose of this study is to collect biologically-based data for defining predictors and correlates of the effects of ALTO-300.
- Trial name
- NCT05157945
- Testing
- ALTO-300 PO Tablet
- Where
- 4 sites in United States
- Volunteers
- 148 people
- Sponsor
- Alto Neuroscience
Major Depressive Disorder
A Study of JNJ-40411813 as Supplementary Treatment to an Antidepressant in Adults With Depression and Anxiety Symptoms
The purpose of this study is to evaluate the efficacy and overall safety and tolerability of treatment with adjunctive JNJ-40411813 compared to placebo in patients with MDD with anxiety symptoms being treated with an…
- Trial name
- NCT01582815
- Testing
- JNJ-40411813
- Where
- 26 sites in Bulgaria, Hungary and 4 more
- Volunteers
- 121 people
- Sponsor
- Janssen Research & Development, LLC
Major Depressive Disorder
Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder
The clinical trial will investigate the effect of brexpiprazole on the concept of life engagement in participants with Major Depressive Disorder (MDD) with a current depressive episode.
- Trial name
- NCT04830215
- Testing
- Brexpiprazole
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Breast Carcinoma, Cancer Survivor
Survivorship Care in Reducing Symptoms in Young Adult Cancer Survivors
This randomized clinical trial studies survivorship care in reducing symptoms in young adult cancer survivors. Survivorship care programs that identify the needs of young adult cancer survivors and ways to support them through…
- Conditions
- Breast Carcinoma, Cancer Survivor, Depression, Fatigue
- Trial name
- NCT02192333
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 6 sites in United States
- Volunteers
- 390 people
- Sponsor
- Fred Hutchinson Cancer Center
Opioid Withdrawal, Opioid Use Disorder (OUD)
Sparrow Link Neuromodulation Device for Opioid Withdrawal Management in Hospitalized Adults With Opioid Use Disorder
This study is evaluating the Sparrow Link, a wearable device that delivers gentle electrical signals to nerves in the outer ear (a technique known as transcutaneous auricular neurostimulation, or tAN).
- Trial name
- NCT07079826
- Testing
- Sparrow Link (Active tAN)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Payel Roy
Older Adults, Hearing Impairment
Effect of Psycho-Educational Interventions in Communication Partners of Older Adults With Hearing Impairment
Hearing impairment is a critical health problem throughout the world. In addition, having an impact on the biopsychosocial functioning of older adults, it places enormous stress and burden on communication partners who interact…
- Conditions
- Older Adults, Hearing Impairment, Nursing, Communication Partners
- Trial name
- NCT06559514
- Testing
- Group-based multi-component psychoeducational inventions (GMC-PEIs)
- Where
- Taiwan
- Volunteers
- 92 people
- Sponsor
- National Taiwan University Hospital
Depression
A Safety and Efficacy Study of JNJ26489112 in Patients With Treatment-Resistant Major Depressive Disorder
The purpose of this study is to evaluate the effectiveness and safety of JNJ26489112 compared with an active control (Venlafaxine XR) and placebo in patients with Treatment-Resistant Major Depressive Disorder.
- Trial name
- NCT01114698
- Testing
- Venlafaxine XR, JNJ26489112
- Where
- 14 sites in United States
- Volunteers
- 12 people
- Sponsor
- Janssen Research & Development, LLC
Psychological Distress, Chronic Disease
Interactive Nature-Based Virtual Reality to Reduce Anxiety, Low Mood, and Feelings of Helplessness in Hospitalized Older Adults With Chronic Illness (Zenctuary VR+)
Prolonged hospitalization can reduce opportunities for independent activity, choice, and control and may contribute to passivity, low mood, anxiety, and distress in some older adults.
- Conditions
- Psychological Distress, Chronic Disease, Learned Helplessness
- Trial name
- ZenctuaryVR+ (NCT07712549)
- Testing
- Interactive nature-based virtual reality intervention, Passive nature-based virtual reality exposure
- Where
- 3 sites in Hungary
- Volunteers
- 100 people
- Sponsor
- Moholy-Nagy University of Art and Design
Mental Health Literacy
Testing Mediators and Moderators of a Fotonovela for Depression to Promote Help-seeking Behavior
Although rates of depression are similar in Latinx populations compared to non-Latinx whites (NLW), there are significant disparities in service utilization.
- Trial name
- NCT04319458
- Testing
- Fotonovela, Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of California, Los Angeles
Depressive Symptoms, Anxious Symptoms
Mindfulness for Emerging Adults Experiencing Anxious and/or Depressive Symptoms
Emerging adults (EA; 18 to 29 years old) in Canada are among the age group with highest risk of developing mental health issues. Despite this, they experience especially long wait-times for mental health services.
- Trial name
- NCT03769233
- Testing
- Mindfulness-based Intervention
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- York University
Depressive Symptoms
The Purpose of the Study is to Investigate if a Smartphone App Combined With Internet Based Cognitive Behavioural Therapy (ICBT) Leads to Improved Symtoms in Depressive Adults on Antidepressive Medicine, Compared to a Wait-list Control Condition
The purpose of the study is to investigate if a smartphone app combined with internet delivered cognitive behavioural therapy (ICBT) leads to improved symptoms in depressive adults on antidepressive mediation.
- Trial name
- FIG (NCT06907134)
- Testing
- Smartphone delivered internet-based Cognitive Behavioural Therapy
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Generalized Anxiety, Introspective & Anxiety-Prone Patient
Validation of a Rapid Screening Tool for Anxiety-depressive Disorders in Children, Adolescents and Young Adults Treated in Oncology. Multicenter Study.
In France today, it is estimated that one in every 850 people aged between 20 and 45 is a childhood cancer survivor (CCS), equivalent to around 40,000 to 50,000 people.
- Conditions
- Generalized Anxiety, Introspective & Anxiety-Prone Patient, Depression, Anxiety, Survivors of Childhood Cancer
- Trial name
- HARMONY-Tool (NCT07117058)
- Testing
- New rapid screening tool for anxiety and depressive disorders, SCARED-R-51 (Screen for Child Anxiety Related Emotional Disorders-Revised), HADS (Hospital Anxiety and Depression Scale)
- Where
- 7 sites in France
- Volunteers
- 545 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Depressive Disorder, Major
CONCERTA® (Methylphenidate Hydrochloride) as add-on Therapy in the Treatment of Adult Major Depressive Disorder.
The purpose of this study is to evaluate the effects of the addition of CONCERTA® (methylphenidate hydrochloride, a central nervous system (CNS) stimulant) or placebo in adult outpatients with Major Depressive Disorder who are…
- Trial name
- NCT00246233
- Testing
- methylphenidate
- Volunteers
- 145 people
- Sponsor
- Janssen-Ortho Inc., Canada
Suicide, Suicide, Attempted
Suicide Prevention Among Recipients of Care
Randomized controlled trial to determine the best brief suicide prevention intervention for adults and adolescents who screen positive for suicidal ideation or behavior in emergency departments or primary care clinics.
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation, Social Support
- Trial name
- SPARC (NCT04893447)
- Testing
- SPI+, SP+CC (Caring Contacts)
- Where
- United States
- Volunteers
- 1,520 people
- Sponsor
- St. Luke's Health System, Boise, Idaho
Major Depressive Disorder, Vasomotor Symptoms
Desvenlafaxine Succinate (Pristiq): Postmarketing Surveillance Study Among Filipino Patients
This is a non-interventional study to review safety data on administration of desvenlafaxine succinate among Filipino patients with MDD and VMS per usual clinical practice within the first three years post commercial distribution.
- Trial name
- NCT01353963
- Testing
- desvenlafaxine succinate
- Where
- 3 sites in Philippines
- Volunteers
- 13 people
- Sponsor
- Pfizer
Depression in Older Adults, Heart Rate Variability (HRV)
Recreational Yoga and Emotional-Autonomic Health in Older Adults
Older adults living in nursing homes often experience depression, reduced satisfaction with daily activities, and changes in heart rhythm related to the autonomic nervous system.
- Trial name
- NCT07340840
- Testing
- Recreational Therapy-Based Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Mersin University
COVID-19 Pandemic, Depression, Anxiety
Older Adults' Perceptions of the Impact COVID-19 Pandemic
This multicentre study will be conduct in several Portuguese institutions, which provide care and supporting services for older adults, with aim to assess the impact of COVID-19 pandemic on the cognitive, emotional and social…
- Conditions
- COVID-19 Pandemic, Depression, Anxiety, Cognitive Impairment, Quality of Life
- Trial name
- NCT05379426
- Testing
- Impact COVID-19 pandemic
- Where
- 58 sites in Portugal
- Volunteers
- 880 people
- Sponsor
- Rsocialform - Geriatria, Lda
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