Clinical trials: Adult Depression
Deep Brain Stimulation
Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder…
- Trial name
- NCT06112067
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Self-guided Treatment for Depression
This study will examine the efficacy and safety of a self-guided digital therapeutic app for the adjunct treatment of Major Depressive Disorder compared to a control app in adolescents and adults.
- Trial name
- NCT06028984
- Testing
- Intervention app, Control app
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Big Health Inc.
Major Depressive Disorder
Efficacy Study of Vortioxetine (Lu AA21004) in Adults With Major Depressive Disorder
The purpose of this study is to determine the effectiveness and safety of vortioxetine, once daily (QD), in patients with Major Depressive Disorder.
- Trial name
- NCT00735709
- Testing
- Vortioxetine
- Where
- 48 sites in Australia, Czechia and 13 more
- Volunteers
- 560 people
- Sponsor
- Takeda
Strength, Quality of Life
Update on the Detection of Frailty in Older Adults
The main objective is to update the diagnostic assessment of frailty by correlating several variables with the ultrasound image of the frail elderly patient.
- Conditions
- Strength, Quality of Life, Functional Independence, Functionality
- Trial name
- NCT06218121
- Testing
- Instrumental and Functional Tests that Assess Functional Capacity
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Universidad Europea de Madrid
Limb Injury, Older Adults
Geriatric Trauma Care Program for Living Alone Older Adults With Injuries
To examine the long-term effects of the Geriatric Trauma Care Program (GTCP) regarding pain, functional disability, depression, loneliness, and health-related quality of life among older adults with traumatic injuries who live…
- Conditions
- Limb Injury, Older Adults, Geriatric, Pain
- Trial name
- NCT06902636
- Testing
- Geriatric trauma care program
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Medical University
Treatment Resistant Depressive Disorder
A Study To Evaluate The Safety, Tolerability And Pharmacokinetics of HS-10345 In Treatment-Resistant Depression
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of intranasal HS-10345 (84mg) compared with placebo in participants with treatment-resistant depression (TRD).
- Trial name
- NCT05196971
- Testing
- HS-10345 84mg
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Depression
Efficacy of Rice Bran Extract in Mildly to Moderately Depressed Adults
The investigators conduct a randomized, double-blind, placebo-controlled study to investigate the effects and tolerability of rice bran extract on depressive symptoms and related biomarkers in mildly to moderately depressed…
- Trial name
- NCT05180136
- Testing
- Rice bran extract group, Control group
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Spinal Cord Injuries
Spinal Cord Injury Vocational Integration Program (SCI-VIP)
This study involves research about how to help Veterans with spinal cord injury (SCI) gain employment. During the first couple of years following SCI, many people are concentrating on their rehabilitation and are unable to afford…
- Trial name
- SCI-VIP (NCT00117806)
- Testing
- Arm 1, Arm 2
- Where
- 5 sites in United States
- Volunteers
- 249 people
- Sponsor
- VA Office of Research and Development
Dementia, Neurocognitive Disorders
Cognitive Stimulation in Older Adults With Alzheimer's Disease
This multicentre study, employing a randomised controlled repeated measures experimental design, will be conducted in several Portuguese institutions that provide care and support services for older adults diagnosed with mild to…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT07041008
- Testing
- Digital intervention, Physical/Analogue Intervention
- Where
- 39 sites in Portugal
- Volunteers
- 514 people
- Sponsor
- Rsocialform - Geriatria, Lda
Major Depressive Disorder
Evolution of the Sensory Profile in Depression
The perception of the environment through the study of sensory awareness is important to understand the adaptive or symptomatological behaviors (e.g., withdrawal, increased activity level, stimulation seeking, etc.).
- Trial name
- DEPSENS (NCT05686668)
- Testing
- assessment by scales
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Esquirol
Major Depressive Disorder
Effective of Transcranial Magnetic Stimulation (TMS) vs Treatment as Usual for First-Episode Depression in Adults
This clinical trial aims to assess the effectiveness of Transcranial Magnetic Stimulation (TMS) compared to Treatment as Usual (TAU) in adult patients experiencing their first or second episode of unipolar major depressive…
- Trial name
- NCT06644833
- Testing
- Transcranial magnetic stimulation, Antidepressant
- Volunteers
- 120 people
- Sponsor
- Sultan Qaboos University
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Pain, Chronic, Pain, Musculoskeletal
Assessment of the Efficacy of Digital CBT for Anxiety in Adults With Chronic Musculoskeletal Pain
The present study involves a randomized clinical trial of Digital Cognitive Behavioral Therapy (dCBT) targeting worry and anxiety symptoms in a population with chronic pain and clinical levels of generalized anxiety disorder…
- Conditions
- Pain, Chronic, Pain, Musculoskeletal, Anxiety
- Trial name
- NCT04907656
- Testing
- dCBT
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Boston University Charles River Campus
Depression, HIV
Depression Therapy to Improve Cardiovascular Risk in HIV
This trial will determine if depression treatment will reduce cardiovascular risk in HIV-infected patients already receiving HIV treatments.
- Trial name
- NCT02309372
- Testing
- Beating the Blues
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Indiana University
Major Depressive Disorder
SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder
To evaluate the efficacy of SPD489 for the treatment of executive function impairments (EFI) when used as an adjunct to stable, standard therapy in the setting of partial or full remission from recurrent Major Depressive Disorder…
- Trial name
- NCT00985725
- Testing
- SPD489 (Lisdexamfetamine dimesylate)
- Where
- 33 sites in United States
- Volunteers
- 143 people
- Sponsor
- Shire
Major Depressive Disorder
Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder
The goal of this clinical trial is to learn if zelquistinel works to treat depression in adults. It will also learn about the safety of zelquistinel.
- Trial name
- GATE-251 (NCT06547489)
- Testing
- Zelquistinel
- Where
- 34 sites in United States
- Volunteers
- 164 people
- Sponsor
- Syndeio Biosciences, Inc
Depressive Disorder, Major, Self-Injurious Behavior
Transcranial Magnetic Stimulation in Patients With Depression and Non-suicidal Self-injury
This clinical trial aims to investigate the effects of Transcranial Magnetic Stimulation (TMS) as an adjunctive treatment for young adult patients with depression and non-suicidal self-injury (NSSI).
- Trial name
- NCT06110585
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brain Institute of Rio Grande do Sul
Depressive Symptoms
Physical Exercise and Depressive Symptoms in Moderately or Severely Depressed Adults
This study is a comparative trial comparing the time course of depressive symptoms between moderately and severely depressed participants over a 10-week long exercise program
- Trial name
- EXIMOS (NCT05703776)
- Testing
- Nordic Walking
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Je Bouge Pour Mon Moral
Postpartum Depression
A Study of BRII-297 in Healthy Adult Subjects
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics of BRII-297 in healthy adult subjects.
- Trial name
- NCT05845840
- Testing
- BRII-297
- Where
- Australia
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brii Biosciences Limited