Clinical trials: Adult Depression
Anxiety, Depression
Effect of an Innovative Online Ayurveda Program on the Mental and Physical Health of Home-Based Adults
The overall objective of this study is to evaluate the effects, feasibility, and safety of a comprehensive online Ayurveda whole-systems (WS) intervention that targets the underlying etiological factors influencing mental and…
- Trial name
- NCT06551467
- Testing
- Online Ayurveda Program for Detox and Lifestyle
- Where
- Austria
- Volunteers
- 98 people
- Sponsor
- Maharishi International University
Sleep, Anxiety
Cannabidiol and Older Adult Cannabis Users
Cannabis use increased 10 fold among adults over the age of 65 between 2014 and 2016 but very little data exists on the extent of their harmful effects on health and behavior.
- Conditions
- Sleep, Anxiety, Depression, Pain
- Trial name
- QUARTz (NCT06290063)
- Testing
- fsCBD Cannabidiol, bsCBD Cannabidiol
- Where
- United States
- Volunteers
- 385 people
- Sponsor
- University of Colorado, Boulder
Depression
Theta Burst Stimulation in Young Adults With Depression
For the proposed 2-year study, the investigators will conduct a within-subject, counterbalanced investigation using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) to examine the acute…
- Trial name
- NCT03737032
- Testing
- Intermittent Theta Burst Stimulation, Continuous Theta Burst Stimulation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Erika Forbes
Depressive Symptoms, Stress, Psychological
Effectiveness and Implementation of a Mindfulness Intervention for Depressive Symptoms Among Adults in a FQHC
The objective of this project is to examine the clinical effectiveness of a mindfulness intervention on reducing depressive symptoms among socio-economically disadvantaged, racial/ethnic minority adults and explore factors…
- Conditions
- Depressive Symptoms, Stress, Psychological, Stress, Physiological
- Trial name
- M-Body (NCT03620721)
- Testing
- mindfulness
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Northwestern University
Healthy, Physically Inactive
Effect of Resistance Exercise on Physical and Psychological Factors
Physical inactivity is a key risk factor for cardiovascular and metabolic disorders, negatively affecting emotional well-being by increasing psychological distress and reducing mental health.
- Trial name
- NCT06708325
- Testing
- Resistance Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Monira Aldhahi
Cognitive Function, Well-Being
Singing Groups for Seniors: Well-Being, Cognitive Function and Health
The researchers' implement and measure the effects of a singing group intervention program for older adults, with an RCT design, in a natural context, on the health, well-being and cognitive function of older adults.
- Conditions
- Cognitive Function, Well-Being, Physical Function, Respiratory Function
- Trial name
- Sing4Health (NCT03985917)
- Testing
- Singing Group Intervention Program, Alternative Social and Leisure Activities
- Where
- Portugal
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Iolanda Costa Galinha
Cognitive Function, Depression in Old Age
Computer Presented and Physical Exercises to Maintain Cognitive Function and Emotional Health in Older Adults
The aim of this study is to investigate and compare how 18-weeks of computer-based brain training and physical exercise together can improve physical performance, cognitive function and mood in older adults in a cross-over design…
- Trial name
- NCT04404621
- Testing
- Physical exercise (PE) training and computer-based brain (CBB)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yale University
Bipolar Disorder, Bipolar Depression
Seroquel in Bipolar Depression Versus Lithium
This study is being carried out to see if quetiapine fumarate (Seroquel) is effective in treating bipolar depression during an 8-week acute phase compared with placebo and lithium, followed by continuation treatment for 26 up to…
- Conditions
- Bipolar Disorder, Bipolar Depression, Depression
- Trial name
- NCT00206141
- Testing
- Quetiapine Fumarate (Seroquel™) drug, mood stabilizer (mood)
- Where
- 76 sites in Canada, Croatia and 14 more
- Volunteers
- 672 people
- Sponsor
- AstraZeneca
Dementia, Neurocognitive Disorders
Effect of Individual Reminiscence Therapy in the Elderly People With Neurocognitive Disorders
This research aims to evaluate the ability of individual reminiscence therapy (RT), using a simple reminiscence format, to improve the overall cognitive function, memory, emotional status and quality of life (QoL) of older adults…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT04658394
- Testing
- Reminiscence therapy
- Where
- 13 sites in Portugal
- Volunteers
- 122 people
- Sponsor
- Rsocialform - Geriatria, Lda
Dementia, Mild Cognitive Impairment
Virtual Chair Yoga for Older Adults and Caregivers: Randomized Controlled Trial
Over 700,000 Canadians are affected by dementia costing the health care system approximately $10 billion/year. Due to COVID-19, the government has urged individuals over the age of 70 to stay home, putting this population at risk…
- Trial name
- NCT04884529
- Testing
- Chair-yoga program
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Anxiety Disorders, Depressive Disorders
Virtual Reality-Based Psychotherapeutic and Psychoeducational Intervention for Anxiety and Depression in Children, Adolescents, and Adults
This study is designed as a non-pharmacological, interventional clinical research project to evaluate the feasibility, safety, and implementation of virtual reality (VR)-based psychoeducational and psychotherapeutic interventions…
- Trial name
- VR-PAD (NCT07250971)
- Testing
- Virtual Reality-Based Psychotherapeutic Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Aydın University
Major Depressive Disorder
A Trial of the Safety and Efficacy of SEP-363856 in the Treatment of Adults With Major Depressive Disorder
Demonstrate ability of SEP-363856 to be superior to placebo as an adjunctive therapy to ADT in change from baseline in depressive symptoms (MADRS \& CGI-S) in MDD patients who had an inadequate response to prior ADT therapy.
- Trial name
- NCT05593029
- Testing
- SEP-363856
- Where
- 77 sites in United States, Bulgaria and 5 more
- Volunteers
- 929 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Major Depressive Disorder
The Efficacy of Probiotic Compared With Placebo Commitment Therapy for Treatment of Major Depressive Disorder
The purpose of this study is to evaluate the efficacy of oral administration of probiotic at 9 log CFU/day as adjunctive treatment in reducing the severity of depression in female patients with major depressive disorder with…
- Trial name
- NCT05315401
- Testing
- Probiotic, Acceptance and commitment therapy (ACT)
- Where
- Malaysia
- Sponsor
- Min-Tze LIONG
Diabetes Mellitus, Type 2, Depression
Minimal Psychological Intervention in Diabetes Patients
The purpose of this study is to determine whether the telephone-delivered Minimal Psychological Intervention (MPI) could improve diabetes' depressive symptom and diabetes-related immediately , as well as HbA1c level in the…
- Trial name
- NCT02473081
- Testing
- Minimal psychological intervention, Usual care
- Volunteers
- 182 people
- Sponsor
- National Cheng-Kung University Hospital
Depression
Comparison Study of Family Practice Interventions for Depression in Adults
To determine if treatment of significant depressive symptoms identified in individuals attending a family practice improves either psychiatric outcome, overall health care costs, or Quality of Life (QOL).
- Trial name
- NCT01975207
- Testing
- Treatment as usual, Internet Intervention, Depression Treatment Pathway
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- AHS Cancer Control Alberta
Depression, Anxiety
Hippocampal Plasticity of Young Adults With Childhood Adversity
This study investigates the clinical and neural effects of stress management skill building programs for young adults with childhood adversity.
- Trial name
- NCT02816502
- Testing
- Stress Management Skill Building Program A, Stress Management Skill Building Program B
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Dementia, Mild, Depression
Decision Making Tool for Firearm Storage
This is a one-arm pilot study testing the feasibility and acceptability of a decision aid about safe firearm storage.
- Trial name
- NCT06382194
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Mental Health Issue, Anxiety Disorders
Arts-based Social Prescribing for Mental Health
This is a parallel-group randomised-controlled trial aiming to assess the effect of exposure to the arts on mental health and wellbeing of community dwelling recipients of mental health care.
- Conditions
- Mental Health Issue, Anxiety Disorders, Affective Disorders, Affective Disorders, Psychotic
- Trial name
- AoP-II (NCT07137572)
- Testing
- Art Prescription
- Where
- Greece
- Volunteers
- 541 people
- Sponsor
- KAVADIA ELENI
Major Depressive Disorder
A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder
A Study to Evaluate BMS-986511 in Adults with Major Depressive Disorder
- Trial name
- NCT07772531
- Testing
- BMS-986511
- Where
- 27 sites in United States, Czechia
- Volunteers
- 200 people
- Sponsor
- Bristol-Myers Squibb
Mood Disorder, Neurobehavioral Manifestation
Adolescence, Puberty, and Emotion Regulation
The purpose of this study is to use brain imaging technology to compare how the brains of adolescents and adults are activated during tasks that involve emotional responses.
- Conditions
- Mood Disorder, Neurobehavioral Manifestation, Healthy
- Trial name
- NCT00016731
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Mental Health (NIMH)
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