Clinical trials: Adult Patients
Still's Disease, Adult-Onset, Systemic Inflammation
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
Background: Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD).
- Conditions
- Still's Disease, Adult-Onset, Systemic Inflammation, Arthritis, Autoinflammatory Syndrome
- Trial name
- NCT03510442
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NHL, NHL, Relapsed, Adult
A Study of CLN-978 in Patients With Relapsed or Refractory (R/R) B Cell Non-Hodgkin Lymphoma (B-NHL)
CLN-978-001 is a Phase 1, open-label, dose escalation and dose expansion study of CLN-978 in patients with Relapse/Refractory (R/R) B-cell Non-Hodgkin Lymphoma (B-NHL).
- Trial name
- NCT05879744
- Testing
- CLN-978
- Where
- 6 sites in United States
- Volunteers
- 3 people
- Sponsor
- Cullinan Therapeutics Inc.
Pediatric Cancer, Adolescent and Young Adult Cancer
Improving Communication Between AYA Oncology Patients and Clinicians: A Patient-Centered Intervention
The overarching goal is to develop and demonstrate proof-of-concept of ReSPECT (Reproductive and Sexual Health Patient Education and Communication Tool), a multi-modal communication intervention to improve adolescent and young…
- Trial name
- NCT06982066
- Testing
- ReSPECT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Connecticut Children's Medical Center
Young Adults, Hypertension
Examining the Circadian Timing Effects of the Hypotensive Response to Exercise
The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns.
- Conditions
- Young Adults, Hypertension, Post-Exercise Hypotension, Circadian Rhythm
- Trial name
- XTIME (NCT07049783)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Freda Patterson
Penis/Surgery, Penis/Injuries
Autologous Fat Grafting Beneath Penile Split Thickness Skin Graft Placement During Penile Reconstruction
The goal of this randomized interventional clinical trial is to learn if placement of a thin layer of fatty tissue (fat graft) beneath a split-thickness skin graft on the surface of the penis improved outcomes of surgery in men…
- Conditions
- Penis/Surgery, Penis/Injuries, Penile Skin, Adult-Acquired Buried Penis
- Trial name
- NCT07316491
- Testing
- Autologous fat grafting, Genitourinary Reconstruction with Split-Thickness Skin Grafting
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pittsburgh
PIK3CA Mutations, Advanced Solid Tumors, Adult
A Study of Mutant Selective-Inhibitor (CGT6297), in Patients With Advanced Solid Tumors
This is a Phase 1, two-part, open-label, nonrandomized, dose-escalation and signal-seeking study of CGT6297, evaluating the safety, tolerability, PK, pharmacodynamic (what the drug does to the body), and antitumor activity of…
- Conditions
- PIK3CA Mutations, Advanced Solid Tumors, Adult, Endometrial Cancer, HR Positive/HER-2 Negative Breast Cancer
- Trial name
- NCT07383506
- Testing
- CGT6297
- Where
- 12 sites in United States
- Volunteers
- 90 people
- Sponsor
- Cogent Biosciences, Inc.
Healthy Adult
Cerebrospinal Fluid Kinetics of Urolithin A
The purpose of this study is to determine the impact of Mitopure® consumption on urolithin A (UA) kinetics in cerebral spinal fluid (CSF).
- Trial name
- neURO (NCT07517913)
- Testing
- Mitopure
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Healthy Adult Participants, Gut Health
Exploration of Tolerability and Dose Responses for a Yeast-based Probiotic
The purpose of this study is to evaluate the tolerability and efficacy of a yeast-based dietary supplement on gastrointestinal, mental, and skin health.
- Trial name
- NCT07867496
- Testing
- 9.9 x 10^7 Pichia kluyveri PK88, 1 x 10^8 Pichia kluyveri PK88
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Older Adults (60 - 85 Years Old), Self-care
Acceptance-based Self-care Intervention for Older Adults With Multimorbidity
The proposed 27-month three-arm parallel, repeated measure, randomized controlled trial aims to evaluate an acceptance-based self-care intervention for community-dwelling older adults with multimorbidity.
- Conditions
- Older Adults (60 - 85 Years Old), Self-care, Multimorbidity
- Trial name
- NCT07882992
- Testing
- Acceptance-based activities, Self-care activities
- Where
- Hong Kong
- Volunteers
- 306 people
- Sponsor
- Chinese University of Hong Kong
Healthy Adult Participants
A Phase 1 Multiple Dose Trial in Healthy Adult Participants to Evaluate the Safety, Tolerability, Drug-Drug Interactions, and Pharmacokinetics of TBD11
This is a Phase 1, randomized, double-blind, placebo-controlled, multiple dose trial of TBD11 in healthy adults. It includes a dedicated open-label cohort in which TBD11 will be administered as a single dose with either a strong…
- Trial name
- NCT07883226
- Testing
- TBD11 (300 mg), Itraconazole (200 mg), Rifampicin 600mg
- Where
- South Africa
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gates Medical Research Institute
Healthy Adults
Feasibility, Acceptability, and Safety of a Drug-Free Nasal Spray in Frontline Healthcare Workers
This study looked at whether frontline healthcare workers could use a drug-free nasal spray twice a day for 8 weeks, whether it was safe, and whether they found it acceptable.
- Trial name
- NCT07887958
- Testing
- Nasal Spray
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Akita Biosciences, Inc.
Thoracotomy, Toracosurgery
Preoperative Nutritional Status and Postoperative Outcomes in Geriatric Lung Resection
Malnutrition is a common comorbidity in patients undergoing thoracic surgery. Furthermore, chronic diseases, polypharmacy, low nutrient intake, reduced appetite, and psychological factors-all frequently observed in geriatric…
- Conditions
- Thoracotomy, Toracosurgery, Thoracic Anesthesia, Older Adults (65 Years and Older)
- Trial name
- NCT07889336
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma
Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma
This randomized phase III trial compares how well combination chemotherapy works when given with or without bortezomib in treating patients with newly diagnosed T-cell acute lymphoblastic leukemia or stage II-IV T-cell…
- Conditions
- Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma, Ann Arbor Stage II Childhood Lymphoblastic Lymphoma, Ann Arbor Stage III Adult Lymphoblastic Lymphoma
- Trial name
- NCT02112916
- Testing
- Bortezomib, Cyclophosphamide, Cytarabine
- Where
- 212 sites in United States, Australia and 2 more
- Volunteers
- 847 people
- Sponsor
- National Cancer Institute (NCI)
Periodontitis, Adult
Garlic Product Impact on Periodontitis (GPIP)
This is a randomized, controlled, examiner-blind, 2-treatment parallel group study. The study will be conducted at the Hebrew University, Hadassah, Israel.
- Trial name
- NCT03492723
- Testing
- Aged Garlic Extract
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Solid Tumor, Adult
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
To determine the recommended phase 2 dose (RP2D) of the combination of neratinib and sodium valproate when given to patients with advanced solid tumors.
- Trial name
- NCT03919292
- Testing
- Neratinib, Divalproex Sodium
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Virginia Commonwealth University
Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening
Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening
This study will garner preliminary data to develop a young adult-mediated intervention whereby a younger family member encourages their older family member to get colorectal cancer (CRC) screening.
- Trial name
- NCT05936931
- Testing
- Changes in CRC screening awareness and intentions
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Morbid Obesity, Metabolic Syndrome
Impact GLP-1 Agonists Following Bariatric
Glucagon-like peptide 1 (GLP-1) is a hormone that helps regulate blood glucose levels through improved insulin sensitivity and release of insulin from the pancreas, control hunger, induce satiety and plays a role in the metabolic…
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes Mellitus, Hypertension
- Trial name
- NCT06132477
- Testing
- GLP-1 receptor agonist
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Missouri-Columbia
Astrocytoma, IDH-Mutant, Grade 2, Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-Mutant
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
This phase I trial tests the safety, side effects, and best dose of triapine in combination with radiation therapy in treating patients with glioblastoma or astrocytoma that has come back after a period of improvement…
- Conditions
- Astrocytoma, IDH-Mutant, Grade 2, Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-Mutant, Recurrent Adult Diffuse Midline Glioma, H3 K27-Mutant, Recurrent Astrocytoma, IDH-Mutant
- Trial name
- NCT06860594
- Testing
- Biospecimen Collection, Computed Tomography, Intensity-Modulated Radiation Therapy
- Where
- 43 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Social Isolation in Older Adults, Poverty
Multimodal Training With Immersive Virtual Reality to Improve the Cognitive Health and Emotional Well-being of Older Women Living Alone
This study aims to evaluate the effectiveness of an immersive virtual reality-based multimodal intervention (VirtualDONA) to improve cognitive health and emotional well-being in older women living alone and at risk of poverty.
- Trial name
- VirtualDONA (NCT06956794)
- Testing
- VirtualDONA Multimodal Program
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Consorci Sanitari de Terrassa
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