Clinical trials: Adult Periodontitis
Chronic Periodontal Disease, Aggressive Periodontitis
Transplantation of Bone Marrow Mesenchymal Stromal Cells for Periodontal Regeneration
The goal of this study is to evaluate the capacity of allogeneic bone marrow mesenchymal stromal cells (MSC) to induce bone regeneration in patients with periodontal disease.
- Trial name
- BMMSC (NCT05975892)
- Testing
- Transplantation of allogeneic MSCs in periodontal disease
- Where
- Venezuela
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Venezolano de Investigaciones Cientificas
Tooth Loss
Long-term Results After Systematic Periodontal Therapy
Patients who had had systematic periodontal treatment (antiinfective treatment with subgingival debridement under local anaesthesia and if required periodontal surgery) at the Dept.
- Trial name
- SYSPERIO10 (NCT03048045)
- Testing
- Supportive Periodontal Treatment (SPT)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Chronic Periodontitis Apical, Embedded Tooth
Post-extractive Alveolus Regeneration
Healing of post-extraction alveolus is a complex process that involves soft and hard tissues regeneration. Pain, swelling, difficulty of opening the mouth, delayed healing of bone tissue, alveolitis and horizontal or vertical…
- Trial name
- NCT04763187
- Testing
- Tooth extraction
- Where
- Lithuania
- Volunteers
- 43 people
- Sponsor
- Lithuanian University of Health Sciences
Chronic Periodontitis
1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers
Locally delivered Alendronate (ALN) have potent inhibitory effect on bone and increases new bone formation in chronic periodontitis patients Till date no study has reported the effect of local delivery of ALN in chronic…
- Trial name
- NCT02168543
- Testing
- Alendronate
- Volunteers
- 46 people
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis
Summary The aim of this study is to evaluate through clinical, microbiological and immunological parameters using PLGA microspheres (lactic-co-glycolic acid polyacid) containing doxycycline in periodontal therapy in smokers with…
- Trial name
- NCT02726646
- Testing
- Doxycycline, Mechanical debridement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Periodontitis, Adult, Periodontitis
Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis.
Periodontitis is a chronic inflammatory disease affecting the supporting tissues of the teeth and may negatively affect patients' oral health-related quality of life.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease, Quality of Life
- Trial name
- PAROQoL (NCT07868042)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Periodontitis
Dose Parameters for Photodynamic Therapy on Periodontal Disease
Due to the phenomenon of bacterial resistance, photodynamic therapy (PDT) has been studied as an alternative to the use of antibiotics on the periodontal treatment.
- Trial name
- NCT03262077
- Testing
- Methylene Blue, Methylene Blue Oral Product
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
HIV/AIDS, Periodontal Diseases
Effects of Periodontal Treatment on HIV-infected Patients
Periodontal diseases, such as chronic periodontitis (CP), frequently occur in immunosuppressed patients, including HIV-infected patients.
- Trial name
- NCT03262402
- Testing
- Basic periodontal treatment
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontitis
Evaluation of the Efficacy of 0.8% Hyaluronic Acid Gel
assess the clinical and laboratory effects of the local and sub gingival application of a 0.8% hyaluronic acid gel (GENGIGEL®) as an adjunct to scaling and root planning (SRP) in chronic moderate to severe periodontitis patients…
- Trial name
- NCT03311906
- Testing
- 0.8% Hyaluronic Acid, Scaling and Root Planing
- Where
- Saudi Arabia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Chronic Periodontitis, Diabetes Mellitus
Low-level Laser Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabetics
The aim of this study was to investigate the local effect of adjunct low-level laser therapy (LLLT) for the treatment of moderate to severe chronic periodontitis in type 2 diabetic patients.
- Trial name
- NCT02817152
- Testing
- Periodontal ultrasonic debridement, Debridement plus low-level laser therapy
- Volunteers
- 20 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periodontitis, Adult, Periodontitis, Aggressive
Efficacy of Sub-gingival Air-polishing With Erythritol in the Treatment of Periodontitis
The first step in the management of periodontal disease involves the non-surgical removal of the soft and hard bacterial deposits at all supra- and sub-gingival sites, especially into deep pockets, which can be carried on with…
- Trial name
- GBT2017 (NCT04264624)
- Testing
- Perioflow and Erythritol powder and ultrasonic debridement, Airflow and Erythritol powder and ultrasonic debridement
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Periodontal Diseases
Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects
The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus.
- Trial name
- NCT03727035
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis
Local Host Modulating Agents Alendronate & Aloe Vera for Treatment of Furcation Defects in Chronic Periodontitis
Alendronate (ALN), commonly use bisphosphonates is proposed to have osteostimulative properties in vivo and in vitro, as shown by an increase in the matrix formation, and acts as a potent inhibitor of bone resorption.
- Trial name
- NCT03204097
- Testing
- Alendronate, Aloe Vera
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis, Generalized
Clinical Effects of Limosilactobacillus Reuteri Probiotics as an Adjunct to the Treatment of Periodontitis
The purpose of this study is to evaluate the clinical efficacy of a probiotic lozenge containing Limosilactobacillus reuteri as an adjunct to the periodontal non-surgical treatment of patients with stage II, grade A, B and C…
- Trial name
- NCT05734274
- Testing
- Probiotics, Negative control
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Universidade do Porto
Chronic Periodontitis
Perio. Maint. With Diode LBR
The primary aim of this pilot study is to determine whether the test methods described feasibly achieve the goal defined for a future clinical study.
- Trial name
- NCT05276817
- Testing
- Epic Diode, HP
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Biolase Inc
Chronic Periodontitis
Effects of Ozone Therapy on Clinical Parameters and Inflammatory Cytokines in Chronic Periodontitis Patients
The objective of this study is to evaluate of ozone therapy on both clinical and biochemical effects in periodontally patients.
- Trial name
- NCT03874390
- Testing
- ozone
- Volunteers
- 50 people
- Sponsor
- Ataturk University
Periodontal Disease, Chronic Periodontitis
Evaluation of Techniques for Scaling and Root Planing and One Stage Full Mouth Disinfection
Evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.
- Trial name
- NCT02126267
- Testing
- Scaling and root planing, Full mouth disinfection, Chlorhexidine gel and gluconate
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Centro Universitario de Lavras
Platelet-Rich Fibrin
Titanium-prepared Platelet-rich Fibrin in Periodontal Regeneration
In this study, the possible effect of blood group distribution on the content of blood biomaterial was investigated. 64 volunteers were included in the study. Various parameters were evaluated.
- Trial name
- NCT05409495
- Testing
- periodontal surgical procedure (open flap debridement), periodontal surgical procedure (OFD +autogenous Titanium-prepared platelet-rich fibrin (OFD+ T-PRF))
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Oral Disease, Cardiovascular Diseases
Oral Health in Adults: Social Gradients and Correlation With Cardiovascular Health
Non-communicable diseases (NCDs) are rising in prevalence because of aging, unhealthy diet and sedentary lifestyle, and common NCDs are caries and periodontitis (here oral diseases) and cardiovascular disease (CVD).
- Conditions
- Oral Disease, Cardiovascular Diseases, Diabetes
- Trial name
- HUSK (NCT05758467)
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Chronic Periodontitis
Simvastatin and Metformin in Chronic Periodontitis
This randomized controlled clinical trial compares efficacy of 1.2% simvastatin with 1% metformin in chronic periodontitis subjects.
- Trial name
- NCT02372656
- Testing
- 1% Metformin, 1.2% Simvastatin
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore