Clinical trials: Adult Periodontitis
Periodontitis
PAROMIP Pilot Study PAROdontites & MIcrobiota Periodontal
A new classification of periodontal diseases was created in 2018. the investigators want to know if this clinical classification is based, or not, on a biological reality.
- Trial name
- PAROMIP (NCT04251650)
- Testing
- subgingival plaque sample, CGF sample
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Nantes University Hospital
Periodontitis
Validation of Hindi Version Oral Health Impact Profile for Periodontitis
Translation of OHIP-CP questionnaire in Hindi language will be done. Patients recruited will undergo clinical examination and recording of periodontal parameters (Pocket probing Depth and Clinical Attachment Loss) will be…
- Trial name
- NCT07303491
- Testing
- OHIP-P-HIN Questionnaire
- Where
- India
- Volunteers
- 196 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Gingival Massage, Chronic Periodontitis
Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis
Chronic Periodontitis is an inflammatory condition and a common disease worldwide. Honey has been used in dentistry for its beneficial properties.
- Trial name
- NCT05231096
- Testing
- Aloe-vera gel, sidr honey, Scaling ans root Debridement
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Generalized Chronic Periodontitis
Garcinia Mangostana L.Pericarp Gel as a Local Drug Delivery in Treatment of Chronic Periodontitis
A single-center, randomized controlled clinical trial was done to assess the periodontal status of the individuals and the presence of red complex microorganisms (RCM) such as Treponema denticola, Porphyromonas.gingivalis and…
- Trial name
- NCT02880397
- Testing
- Garcinia mangostana
- Volunteers
- 50 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontal Diseases, Epigenetics
DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.
Periodontitis is related to host genetics, constitution of the dental biofilm and environmental factors such as smoking. DNA methylation is a mechanism of genetic expression that can inhibit or silence gene expression.
- Trial name
- NCT03371446
- Testing
- oral epithelial cells obtained by rinsing with 3% sucrose
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Periodontitis
Osteoprotegerin Before and After Periodontal Surgery
The study hypothesis: Is Osteoprotegerin a diagnostic and/or prognostic marker of periodontal disease?
- Trial name
- NCT02160613
- Testing
- Open flap debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Long-term Safety of Minocycline in Patients With Gum Disease
This study will look at the safety of using the study medicine for a long time. It will see if the germs get used to the medicine, making it not work as well, if it's used by people with gum disease for a long time.
- Trial name
- NCT00668746
- Testing
- Minocycline HCl microspheres
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- OraPharma
Rheumatoid Arthritis, Chronic Periodontitis
Impact of Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment on Clinical and Biochemical Parameters Among Patients Having Mild Rheumatoid Arthritis With Periodontitis
Purpose: To evaluate the efficacy of photodynamic therapy (PDT) as an adjunct to non-surgical periodontal therapy on the clinical periodontal and biochemical parameters among patients with rheumatoid arthritis (RA) having…
- Trial name
- NCT05122117
- Testing
- Methylene blue mediated Photodynamic therapy, Non-surgical periodontal therapy
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Zohaib Akram
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Periodontitis
Probiotic Use in Chronic Periodontitis Patients
Aim: to evaluate the additional effects of the 12 weeks usage of a Streptococcus containing probiotic tablet after scaling and rootplaning compared to a placebo tablet.
- Trial name
- NCT02403960
- Testing
- probiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Chronic Periodontitis
Platelet-rich Fibrin With 1.2% Rosuvastatin in Chronic Periodontitis Treatment
The present study is designed to evaluate the combined efficacy of Platelet Rich Fibrin (PRF) and 1.2% Rosuvastatin (RSV) with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis patients
- Trial name
- NCT02645227
- Testing
- Open flap debridement (OFD), OFD with Platelet rich fibrin (PRF), OFD with PRF and 1.2% Rosuvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Full-mouth Periodontal Debridement and Metronidazole Gel in Patients With Chronic Periodontitis
Hypothesis: metronidazole gel applied topically after periodontal debridement in smokers volunteers could improve clinical parameters when compared to metronidazole tablets + periodontal debridement.
- Trial name
- NCT01938183
- Testing
- Full-mouth periodontal debridement, Metronidazole tablet, Metronidazole benzoate gel
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Chronic Periodontitis
Effect of Tooth Cleaning in Smokers and Non Smokers With Gum Disease.
This study is intended to measure hepatocyte growth factor levels in smokers and non smokers with periodontitis before and after non surgical periodontal therapy.
- Trial name
- ETCSNSGD (NCT02930356)
- Testing
- NSPT, Scaling and root planing
- Volunteers
- 40 people
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Chronic Periodontitis
Role of NLRP6 in Chronic Periodontitis
The quantification of NLRP6 in blood samples will be analyzed from individuals with chronic periodontitis but without systemic disease.
- Trial name
- NCT06400069
- Testing
- Evaluation of serum NLRP6 levels
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Babol University of Medical Sciences
Chronic Periodontitis
Different Surgical Modalities in the Treatment of Periodontitis
The purpose of the present study is to determine: 1) the efficacy of 2 periodontal surgical procedures, the conservative simplified papilla preservation technique and the more resective open flap debridement with osseous…
- Trial name
- NCT01642641
- Testing
- Non-surgical Subgingival Debridement (SD), Simplified Papilla Preservation Flap, Resective Periodontal Flap with Osseous Recontouring (RPFO)
- Where
- 3 sites in United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Chronic Periodontitis
Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis
Effect of Locally Delivered Antioxidants as An Adjunct to Non-surgical Periodontal Therapy on GCF Level of Oxidative Stress Marker; Protein Carbonyl
- Trial name
- NCT03203746
- Testing
- Lycopene + SRP, SRP only
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maie Sami tawfik
Periodontitis
The Safety and Tolerability of Initial Periodontal Therapy Combined With Human Dental Pulp Stem Cell Injection in the Treatment of Chronic Periodontitis
The principal objective of this trial is to investigate the safety and tolerability of human dental pulp stem cells injection in the treatment of chronic periodontitis.
- Trial name
- NCT04983225
- Testing
- Human Dental Pulp Stem Cells, Saline solution
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Peking University Third Hospital
Chronic Periodontitis
Tissue Plasminogen Activator & Plasminogen Activator Inhibitor Type-1 In Gingival Tissues Of Chronic Periodontitis
Tissue Plasminogen Activator and Plasminogen Activator Inhibitor Type-1 Gene Expression will be evaluated clinically and histopathologically through Hematoxylin and eosin as well as by quantitative reverse transcription…
- Trial name
- NCT03803176
- Testing
- Open Flap Debridement
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Adult, Inflammation Gum
Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.
This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient.
- Trial name
- NCT05646459
- Testing
- cannabidiol, floss, proxabrush
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska