Clinical trials: Adult Periodontitis
Periodontal Diseases, Coronary Disease
Quantification of Micro-RNA 146-a in Chronic Periodontitis and Coronary Heart Disease Subjects
The expression and quantification of Micro-RNA 146-a, was analyzed in the subgingival plaque samples of generalized chronic periodontitis patients with and without coronary heart disease.
- Trial name
- NCT03721159
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Diabetes Mellitus, Chronic Periodontitis
PRF Growth Factors Levels in Diabetic Patients With Chronic Periodontitis
Diabetic patients may show different release of growth factors when microvascular complications such as; retinopathy or periodontitis are seen.
- Trial name
- NCT02304497
- Testing
- Platelet Rich Fibrin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Chronic Periodontitis With Mandibular Degree 2 Furcation Defects
Boric Acid in Degree 2 Furcation Defect
The purpose of this double-masked, randomized, controlled clinical trial was to evaluate the effects of subgingival delivery of boric acid gel as an adjunct to scaling and root planing (SRP) on clinical and radiographic…
- Trial name
- NCT02738515
- Testing
- 0.75 % Boric Acid
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Obesity
The Effects of Obesity on Glutathione Levels in Patients With Chronic Periodontitis Before and After Periodontal Therapy
Obesity may affect periodontal health by inducing gingival oxidative damage through increased production in circulating reactive oxygen species (ROS).
- Trial name
- NCT02498561
- Testing
- nonsurgical periodontal therapy, oral hygiene instructions
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Figen ÖNGÖZ DEDE
Generalized Adult Periodontitis
The Efficacy and Safety of 2.5 mg Chlorhexidine Gluconate Chip (PerioChip®) in Frequent Treatment Versus Routine Treatment in Therapy of Adult Chronic Periodontitis
The purpose of this study is to assess the efficacy and the safety of Chlorhexidine Gluconate Chip (PerioChip®) in frequent treatment versus routine treatment in therapy of adult chronic periodontitis.
- Trial name
- NCT01249846
- Testing
- PerioChip ®
- Where
- Israel
- Sponsor
- Dexcel Pharma Technologies Ltd.
Alveolar Bone Loss Associated Chronic Periodontitis
Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis
This open label, randomized controlled clinical trial study will be conducted after obtaining ERC approval of Bahria University Health Sciences. Written informed consent will be taken from all study participants.
- Trial name
- NCT06856369
- Testing
- Platelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bahria University
Chronic Periodontitis
Clinical and Microbiological Efficacy of Systemic Ayurvedic Immunomodulator Septilin in the Treatment of Chronic Periodontitis
The present clinical trial was designed to investigate the clinical and microbiological effectiveness of systemic ayurvedic immunomodulator Septilin as an adjunct to scaling and root planing (SRP) in the treatment of chronic…
- Trial name
- NCT02013323
- Testing
- Scaling and root planing, and Septilin for 7 days
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Thyroid Diseases, Chronic Periodontitis
Thyroid Disease and Chronic Periodontitis
Currently, the investigators are unaware of any previous studies that have analyzed the relationship between the prevalence of thyroid disease and chronic periodontitis among adults utilizing a retrospective, cross-sectional…
- Trial name
- NCT03369405
- Testing
- NO intervention, patient records review only
- Where
- United States
- Volunteers
- 4,965 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Periodontitis
Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis
This study is to determine whether scaling and root planning (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with…
- Trial name
- NCT00297518
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Ondine Research Laboratories
Chronic Periodontitis
Influence of Gingival Biotype on the Outcome of Open Flap Debridement
The influence of periodontal thickness has been documented in outcome of various periodontal interventions like non surgical periodontal therapy, mucogingival therapy, guided tissue regeneration (GTR), crown lengthening and…
- Trial name
- NCT03882138
- Testing
- open flap debridement
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Adult, Furcation Defects
A Chitosan Brush and Enamel Matrix Derivative for Non-surgical Treatment of Furcations
Patients diagnosed with stage III or IV periodontitis who exhibit mandibular first or second molars with Class II, Subclass A, or B buccal and/or lingual mandibular furcation defects (horizontal probing depth of ≥ 3 mm ) will be…
- Conditions
- Periodontitis, Adult, Furcation Defects, Furcation of Root of Tooth, Periodontitis Complex
- Trial name
- NCT06684769
- Testing
- Emdogain® FL, Labrida BioClean®
- Where
- Latvia
- Volunteers
- 40 people
- Sponsor
- Riga Stradins University
Chronic Periodontitis
Identification of EMT Indicators in Healthy and Periodontally Diseased Gingival Samples
The current study focuses on the localization and quantitative assessment of growth factors and cytokines related to the EMT process found in the human gingival tissue samples taken from periodontally diseased individuals…
- Trial name
- NCT03462953
- Testing
- Gingival tissue samples will be harvested
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Emblica Officinalis Irrigation in Periodontitis
E. officinalis fruit possesses both the antimicrobial and anti-inflammatory activities that may prove to be useful against several periodontal diseases with the advantage that it is devoid of side effects associated with…
- Trial name
- NCT03295461
- Testing
- SRP+ 10% Emblica officinalis irrigation, SRP + 0.2% Chlorhexidine irrigation), SRP + 0.9% Saline irrigation
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Adult, Metabolic Syndrome
Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome
The aim of this study is to investigate the systemic impact of periodontitis in patients with Metabolic Syndrome, by assessing measures of sub-clinical atherosclerosis and cardiovascular risk, microbial factors and host genetic…
- Trial name
- NCT03297749
- Testing
- Observational study (no intervention)
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 102 people
- Sponsor
- University College, London
Chronic Periodontitis
Evaluation of Local Delivery of Aloe Vera Gel as an Adjunct to Non-surgical Treatment in Patients With Chronic Periodontitis
Aim of the current study was to evaluate the effect of Aloe vera gel as an adjunct to scaling and root planing (SRP) in the management of chronic periodontitis.
- Trial name
- NCT04615585
- Testing
- Aloe vera after SRP, Scaling and root planing (SRP)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nourhan M.Aly
Chronic Periodontitis, Aggressive Periodontitis
B Cell Functions in Periodontitis
The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen.
- Trial name
- LBPARO (NCT02833285)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Chronic Periodontitis, Oral Cancer
The Link Between Periodontitis, Smoking and Oral Cancer
Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and…
- Trial name
- NCT04047212
- Testing
- biopsy for oral cancer, periodontal examination
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Chronic Periodontitis
Probiotics Effects to Initial Periodontal Treatment
The aim of this study is to evaluate the clinical and microbiological effects of Bifidobacterium animalis subsp. lactis DN-173010 containing yoghurt as an adjunct to mechanical periodontal treatment.
- Trial name
- NCT05408364
- Testing
- probiotic or natural yoghurt, SRP
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marmara University
Diabetes Mellitus, Periodontitis
Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis
Background: Propolis is a natural resin made by bees from various plant sources. Propolis exerts antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and antidiabetic properties.
- Trial name
- NCT02794506
- Testing
- Propolis
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Mohamed Anees
Obstructive Sleep Apnea of Adult, Periodontal Diseases
Periodontal Disease in Patients With Obstructive Sleep Apnea
Investigators hypothesize that in patients with obstructive sleep apnea (OSA) the severity of periodontal disease is significantly higher compared to patients without OSA in every aspect, including PI, PD, CAL and BOP.
- Conditions
- Obstructive Sleep Apnea of Adult, Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss
- Trial name
- NCT04581798
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University