Clinical trials: Adult Periodontitis
Chronic Periodontitis
Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis.
Aim of the study is the efficiency assessment of porous Metronidazole loaded matrix based on gelatin/hydroxyethylcellulose blend in treatment of deep periodontal pockets resulting from severe chronic periodontitis.
- Trial name
- NCT03791099
- Testing
- Metronidazole
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Periodontal Diseases
Active Matrix Metalloproteinase-8 (aMMP-8) Chair-side Test in Different Periodontal Disease
The aim of this study to evaluate the diagnostic accuracy of a new qualitative aMMP-8 POC test in different periodontal health and disease and as compared to the established quantitative laboratory method (ELISA)
- Trial name
- NCT03527901
- Testing
- GCF collection with aMMP-8 chair side test, Saliva collection
- Volunteers
- 103 people
- Sponsor
- Aydin Adnan Menderes University
Chronic Periodontitis
Evaluation of the Efficacy of Probiotics in Chronic Periodontitis Patients
Periodontitis is an infectious inflammatory disease. Bacteria modulate the inflammatory response and alter the diversity of periodontal disease.
- Trial name
- NCT02390687
- Testing
- Probiotic
- Where
- India
- Volunteers
- 31 people
- Sponsor
- Next Gen Pharma India Pvt. Ltd.
Periodontal Diseases, Diabetes Mellitus
Comparison of Two Oral Hygiene Routines on the Glycemic Control for Type 2 Diabetes Patients With Chronic Periodontitis
This study aims to compare two common oral hygiene routines on the improvement of glycemic control and oral health parameters in moderate to severe periodontitis patients with uncontrolled type 2 diabetes (T2DM).
- Trial name
- NCT05260814
- Testing
- Electric toothbrush with smart phone app
- Volunteers
- 40 people
- Sponsor
- Harvard School of Dental Medicine
Periodontitis
Prevalence of Periodontitis in Sample of Egyptian Population
Prevalence of Periodontitis on a Sample of Adult Egyptian Population: A Cross-sectional study
- Trial name
- prevalence (NCT05317208)
- Where
- Egypt
- Volunteers
- 581 people
- Sponsor
- Cairo University
Periodontitis
Effect of Periodontitis Treatment on Quality of Life and Experiences of Fear, Anxiety and Pain
There are different protocols to treat gum diseases. One relevant differential aspect is related to time. There are protocols that usually takes one to two months to be completed while other are completed within 24 hours.
- Trial name
- NCT02409966
- Testing
- Quadrant-wise scaling, Full-mouth 24-hour scaling
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Taubate
Periodontal Diseases, Biomarkers
Impact of Periodontal Treatment on the RANKL/OPG Ratio in Crevicular Fluid
Objectives: Alveolar resorption is one of the most important events in periodontitis. Osteoclast activity is regulated by the ratio between receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG).
- Conditions
- Periodontal Diseases, Biomarkers, Bone Resorption
- Trial name
- NCT03787875
- Testing
- periodontal treatment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Chronic Periodontitis
PDT As An Adjunct To SRP In The Management of Chronic Periodontitis
The present study aims to evaluate photodynamic therapy (PDT) using Zinc oxide as a photosensitizer as an adjunct to scaling and root planing (SRP) in the management of chronic periodontitis.
- Trial name
- NCT03770819
- Testing
- Photodynamic therapy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Chronic Periodontitis
A Phase II Clinical Trial of YH23537 in Patients With Chronic Periodontal Disease.
This study is designed to evaluate the efficacy and the safety of YH23537 in Korea patients with chronic periodontitis, in order to investigate the recommended therapeutic dose.
- Trial name
- NCT02585596
- Testing
- YH23537 1000mg/day, YH23537 2000mg/day, YH23537 3000mg/day
- Where
- South Korea
- Volunteers
- 275 people
- Sponsor
- Yuhan Corporation
Periodontitis, Smoking
Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis
This study comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects.
- Trial name
- NCT03426241
- Testing
- no intervention
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Baskent University
Chronic Periodontitis
Pre-procedural Mouthwash in Reducing Bacteria in Dental Aerosols
The aim of this randomized, single blinded clinical trial was to evaluate the effect of a pre-procedural mouthwash containing cetylpyridinium chloride (CPC), zinc lactate (Zn) and sodium fluoride (F) in the reduction of viable…
- Trial name
- NCT02875769
- Testing
- Dental prophylaxis, Mouthwash CPC+Zn+F, Mouthwash CHX
- Volunteers
- 60 people
- Sponsor
- University of Guarulhos
Chronic Peritonitis
Effects of Vitamin D on Moderate to Severe Periodontitis
The object of the study was to evaluate the direct effect of high dose vitamin D supplementation on chronic periodontitis, and suggest the recommended dose for clinic use.
- Trial name
- NCT03044886
- Testing
- vitamin D
- Volunteers
- 360 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Periodontitis
Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis
To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.
- Trial name
- NCT03043066
- Testing
- Scaling and root planing, scaling and root planing along with antibiotic intervention
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Stage II, Grade B Periodontitis, Chronic Periodontitis
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
This clinical trial is designed to evaluate two locally delivered gels, metformin and chlorhexidine, as adjunctive therapies to scaling and root planing (SRP) in patients with Stage II, Grade B periodontitis.
- Trial name
- MET-CHX Perio (NCT07215156)
- Testing
- Arm 1 Scaling and Root Planing (SRP), Arm 2 Metformin Gel 1% (locally delivered), Arm 3 Chlorhexidine Gel 0.2% (locally delivered)
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Chronic Periodontitis
Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers
Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species.
- Trial name
- NCT02329353
- Testing
- Lactobacillus brevis CD2 Lozenges
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Next Gen Pharma India Pvt. Ltd.
Periodontitis, Cigarette Smoking
The Impact of Cigarette Smoking on Periodontal Therapy
Periodontitis patients, 40 cigarette smokers and 40 non-smokers (defined by cotinine measures in serum), were recruited to this double arm prospective cohort study.
- Trial name
- NCT05120206
- Testing
- Non-surgical periodontal therapy: motivation and instruction in oral hygiene, debridement using handinstrumentation (Hu-Firedy,Chicago, IL, USA;and American Eagle Instruments,Missoula, MT,USA).
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Chronic Periodontitis
Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis
Periodontitis is an infectious inflammatory disease affecting the periodontal tissue (Gingivae, alveolar bone, periodontal ligament and cementum).
- Trial name
- NCT03270280
- Testing
- Nigella Sativa Oil, Normal saline
- Where
- Pakistan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
Chronic Periodontitis
Treatment of Chronic Periodontitis With Repeated Adjunctive Antimicrobial Photodynamic Therapy
Chronic periodontitis (CP) is an infectious disease resulting in inflammation of the supporting structures of the teeth, progressive loss of bone loss and insertion.
- Trial name
- TCPWRAAPT (NCT02734784)
- Testing
- Photodynamic Therapy
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Chronic Periodontitis Wth Diabetes Mellitus
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial.
Statins are specific competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known for its hypolipidemic actions, possessing biologically significant anti-inflammatory and antioxidant properties…
- Trial name
- NCT03745300
- Testing
- ATORVASTATIN, SIMVASTATIN
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
CHRONIC PERIODONTITIS
Injectable Platelet Rich Fibrin With Non Surgical Periodontal Therapy
Clinical evaluation of local subgingival application of injectable platelet-rich fibrin ( i-PRF ) for chronic periodntitis as adjunctive to non surgical therapy and compare it with hyaluronic acid.
- Trial name
- NCT04070729
- Testing
- Hyaluronic acid gel, Platelet rich fibrin
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institute of Dental Sciences, Bareilly, Uttar Pradesh, India