Clinical trials: Adult Periodontitis
Chronic Periodontitis Complex
Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.
Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics.
- Trial name
- NCT03692819
- Testing
- Amoxicillin 500 Mg, Lactobacillus reuteri Oral Drops
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Chronic Periodontitis
Role of Leukotriene Receptor Antagonists in Treatment of Chronic Periodontitis
The adjunctive use of Leukotriene Receptor Antagonist (Montelukast) along with scaling and root planing in patients with chronic periodontitis leads to host inflammatory response modulation and decrease in serum C reactive…
- Trial name
- NCT02014532
- Testing
- Montelukast
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Chronic Periodontitis
Evaluation of Acacia Catechu and Low-Level Laser in the Treatmentof Stage II Periodontitis
Evaluation of Acacia catechu and Low-Level Laser in the Treatment of Stage 2 Periodontitis.
- Trial name
- LLLvsAgel (NCT06805292)
- Testing
- Acacia catechu, Low Level Laser Therapy, phase 1 therapy chronic periodontitis
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Faculty of Dental Medicine for Girls
Smoking, Chronic Periodontitis
Apoptotic Changes in Gingiva Caused by Smoking
Smoking is a major environmental risk factor associated with common forms of human chronic periodontitis. The aim of the present study was to evaluate apoptotic tissue alterations and tissue destruction in smoker and non-smoker…
- Trial name
- NCT03631498
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Chronic Periaortitis, Intrabony Periodontal Defect
Atorvastatin as an Adjunct to DFDBA in Intrabony Defects
Periodontitis is a major oral health problem which leads to the progressive destruction of periodontal ligament and alveolar bone with pocket formation, recession or both.
- Trial name
- NCT03009097
- Testing
- DFDBA, DFDBA with atorvastatin
- Volunteers
- 26 people
- Sponsor
- Kamineni Institute of Dental Sciences
Adult Periodontitis
"Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects"
Study aims to evaluate clinical and radiographic effectiveness of 1.2% Rosuvastatin gel in the treatment of Infrabony defects in chronic periodontitis patients.
- Trial name
- NCT03677297
- Testing
- Rosuvastatin
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Chronic Periodontitis
Effect of the Diode Laser on Bacteremia Associated With Periodontal Flap Surgery: A Clinico-Microbiological Study
The objective of the present study is 1. To study the incidence and magnitude of bacteremia after periodontal flap surgery . 2. To compare and evaluate the effect of diode laser on frequency of bacteremia associated with…
- Trial name
- NCT04207034
- Testing
- flap surgery with diode laser, flap surgery
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Chronic Periodontitis, Probiotics
Adjunctive Probiotics in Chronic Periodontitis
This study will assess clinical and microbiological efficacy of probiotics and antibiotics in patients of chronic periodontitis as an adjunctive to scaling and root planing (SRP) in reducing bacterial count and in improving…
- Trial name
- NCT03499184
- Testing
- P Flor locally delivered, P Flor systemically administered, Amoxil 500 mg Oral Capsule
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziauddin Hospital
Chronic Periodontitis
IgY Efficacy on Periodontitis Patients
Patients visiting National Hospital of Odonto-Stomatology for treating periodontitis used a food supplement (lozenge) containing chicken egg antibody (IgY) against Porphyromonas gingivalis gingipains as an adjunct to conventional…
- Trial name
- NCT02705885
- Testing
- lozenges containing IgY
- Volunteers
- 60 people
- Sponsor
- Immunology Research Institute in Gifu
Chronic Periodontitis, Bone Loss
Regenerative Potential of Advanced Platelet Rich Fibrin and Bioactive Glass (Perioglas®).
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis…
- Conditions
- Chronic Periodontitis, Bone Loss, Intrabony Periodontal Defect
- Trial name
- NCT04767243
- Testing
- open flap debridement and filled with A-PRF ( Advanced platelet rich fibrin), open flap debridement and filled with Bioactive glass (Perioglas®), open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Periodontitis Chronic Generalized Severe
Flurbiprofen Versus Aloe Vera Gel in the Treatment of Chronic Periodontitis in Smoking Patients.
This study aims to evaluate clinically the efficacy of flurbiprofen gel in comparison to Aloe Vera gel as adjunctive to SRP in the reduction of periodontal pockets in patients with chronic periodontitis in smoking patients.
- Trial name
- NCT06041178
- Testing
- 2.5% flurbiprofen, 98% aloe vera
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Beirut Arab University
Chronic Periodontitis
Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection
The purpose of this study is to evaluate beneficial effects of probiotic Lactobacillus brevis CD2 tablets in addition to the primary treatment for patients with chronic periodontitis (Full Mouth Disinfection), at local level and…
- Trial name
- NCT01438333
- Testing
- lactobacillus brevis tablets
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of L'Aquila
Chronic Periodontitis, Diabetes Mellitus
Gingival Crevicular Fluid Vaspin and Omentin Levels in Type 2 Diabetic Patients With Chronic Periodontitis
The aim of the present study were 1) to determine the role of these adipokines in the pathogenesis of periodontal disease, inflammation and tissue destruction comparing with gingival crevicular fluid (GCF) levels of TNF-α, which…
- Trial name
- NCT02544347
- Testing
- gingival crevicular fluid, non-surgical periodontal treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Chronic Periodontitis, Atherosclerotic Cardiovascular Disease
Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal Treatment
The hypotheses tested were that levels of C-Reactive Protein (CRP) would be higher in patients with chronic periodontitis in comparison with those without periodontal disease and that the non-surgical periodontal treatment would…
- Trial name
- NCT01433744
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- State University of Maringá
Chronic Periodontitis
Evaluation of Antimicrobial Photodynamic Therapy in Multiple Applications as a Coadjuvant in the Surgical Therapy of Access to Scaling
Chronic periodontitis is an infectious disease resulting in inflammation of the teeth support structures, progressive periodontal attachment loss and bone loss.
- Trial name
- NCT03498404
- Testing
- Photodynamic Therapy, scaling and root planing
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Periodontitis, Type 2 Diabetes Mellitus
Effect of Non-surgical Periodontal Treatment on HbA1c in Type 2 Diabetic Patients
The main objective is to evaluate the effect of nonsurgical periodontal treatment on serum levels of HbA1c in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT02652026
- Testing
- Nonsurgical periodontal treatment, Dental Prophylaxis
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Periodontitis, Chronic Periodontitis (Disorder)
Cofilin-2 (rs80358250) and Lactoferrin (rs1126478) Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CHD
Periodontitis is a chronic multifactorial inflammatory disease associated with the accumulation of dental plaque and characterized by progressive destruction of the teeth-supporting apparatus, including the periodontal ligament…
- Conditions
- Periodontitis, Chronic Periodontitis (Disorder), Coronary Heart Disease
- Trial name
- NCT07353606
- Testing
- Scaling and root planing
- Where
- 2 sites in India
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis, Coronary Artery Disease
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further.
- Conditions
- Chronic Periodontitis, Coronary Artery Disease, miRNA
- Trial name
- NCT04583085
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis
To Study the Beneficial Effect of Mustard Oil and Salt Massaging With Oral Prophylaxis in Patients With Gum Diseases
Periodontal disease is a chronic inflammatory process accompanied by destruction of Periodontium, and sometimes loss of teeth. Periodontal disease is highly prevalent especially in developing and underdeveloped countries…
- Trial name
- NCT02638740
- Testing
- SCALING AND ROOT PLANING (SRP), MUSTARD OIL AND SALT MASSAGE WITH SRP
- Where
- India
- Volunteers
- 54 people
- Sponsor
- Government College of Dentistry, Indore
Periodontal Disease "Unrecognized Condition"
Design of a Protocol for Obtaining Genomic DNA From Saliva
Objective The aim of this study was to test a protocol for the extraction of high quality genomic DNA from saliva samples obtained with mouthwash and taken from patients with periodontal disease.
- Trial name
- DPOGDNAS (NCT02523326)
- Testing
- saliva samples obtained with mouthwash
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Centro Interdisciplinario de Ciencias de la Salud Unidad Santo Tomás