Clinical trials: Adult Periodontitis
Periodontal Bone Loss, Chronic Periodontitis
Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft
The present study aimed to evaluate the effects of enamel matrix derivatives either alone or combined with autogenous bone graft applied to intrabony defects in chronic periodontitis patients on clinical/radiographic parameters…
- Trial name
- NCT02218515
- Testing
- Open Flap Debridement, EmdogainⓇ(Enamel Matrix Derivative), EmdogainⓇEnamel Matrix Derivative+Autogenous Bone
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Haner Direskeneli, Prof
Preeclampsia, Chronic Periodontitis
microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia.
Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria…
- Trial name
- NCT04277390
- Testing
- clinical intervention for microbial analysis and MIR155 as biomarker
- Where
- India
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Chronic Periodontitis, Periodontal Bone Loss
Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.
The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.
- Conditions
- Chronic Periodontitis, Periodontal Bone Loss, Resistance Bacterial
- Trial name
- NCT03863249
- Testing
- SCALE AND ROOT PLANING, ADJUNTIVE ANTIBIOTICS, MICROBIAL SAMPLING
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- University of Valencia
Chronic Periodontitis
Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects
Background: Furcation is the bifurcation or trifurcation of a multirooted tooth. It is an area of complex anatomic morphology difficult to debride by routine periodontal instrumentation.
- Trial name
- PRFMMFD (NCT02430519)
- Testing
- Furcation treatment with PRF, Furcation Treatment with Allograft and GTR, allograft and guided tissue regeneration (GTR) membrane (DFDBM and Healiguide)
- Volunteers
- 22 people
- Sponsor
- Dr.Syed Asimuddin
Periodontitis, Adult, Prediabetes / Type 2 Diabetes
HbA1c Screening in Dental Care and Primary Care Referral in Patients With Advanced Periodontitis
This study will evaluate whether HbA1c screening can be performed in dental care to detect elevated blood glucose in patients with advanced periodontitis and support referral to primary care.
- Trial name
- DENT-PC (NCT07688278)
- Testing
- Point-of-care HbA1c screening, Conditional standardized primary care referral
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane
Diabetes Mellitus, Chronic Periodontitis
Locally Delivered Aloe Vera Gel in the Treatment of Chronic Periodontitis Patients With Diabetes Mellitus
A study on the effect of locally delivered aloe vera gel as an adjunct to scaling and root planing in the treatment of chronic periodontitis patients with controlled type II diabetes mellitus.The evaluation of Plaque Index…
- Trial name
- NCT02437747
- Testing
- SRP + Aloe, SRP
- Volunteers
- 15 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Chronic Periodontitis, Type 2 Diabetes Mellitus
Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy
1. Are adipokines involved in pathogenesis of periodontal disease in diabetic patients? 2. Does their level change after periodontal therapy?
- Trial name
- NCT02174146
- Testing
- non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Plaque Formation Rate and Toothpaste
This 12-week prospective, randomized, double-blind, two-center trial evaluated the impact of a microcrystalline zinc-hydroxyapatite (mHA) dentifrice on plaque formation rate (PFR) in periodontitis patients.
- Trial name
- PFR (NCT02697539)
- Testing
- AmF/SnF2, mHA
- Volunteers
- 74 people
- Sponsor
- University Hospital Muenster
Chronic Periodontitis
Adjunctive Photodynamic Therapy in Treatment of Chronic Periodontitis
The aim of this study is to verify the efficacy of Photodynamic Therapy (PDT) as an adjunct to non-surgical treatment of chronic periodontitis by assessing clinical and microbiological and immunological parameters.
- Trial name
- NCT01034501
- Testing
- photodynamic therapy
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- University of Sao Paulo
Chronic Periodontitis
Evaluation of SilOss® in Periodontal Surgery
Siloss® (Azurebio, Madrid, Spain) is a synthetic and inorganic bone graft material and is composed of a dicalcium phosphate anhydrous (monetite), hydroxyapatite (HA), and amorphous silica and trace amounts of zinc.
- Trial name
- NCT02639572
- Testing
- Siloss® bone graft, Hydroxyapatitie Bone graft
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Chronic Periodontitis
Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.
The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.
- Trial name
- NCT03644901
- Testing
- nonsurgical periodontal treatment
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Periodontal Regeneration
Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect
Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each.
- Trial name
- RCT (NCT04786327)
- Testing
- Minimal invasive flap technique, Minimally invasive flap with root conditioning (EDTA) and platelet rich fibrin, minimally invasive flap with root contioning by EDTA and growth factor enhanced matrix GEM21S
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tanta University
Periodontitis
Diode Laser and SRP in Chronic Periodontitis
The purpose of this study is to compare the efficacy of photoablative and photodynamic diode laser in adjunct to scaling-root planing (PAPD+SRP) and SRP alone for the treatment of periodontitis.
- Trial name
- PAPD (NCT02407379)
- Testing
- PAPD+SRP
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Odontostomatologic Laser Therapy Center, Florence, Italy
Chronic Periodontitis
Applied The Platelet Rich Fibrin in Chronic Periodontitis
Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in…
- Trial name
- NCT02594605
- Testing
- Platelet Rich Fibrin, Conventional Flap Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Periodontal Diseases
Microbial Profiling in Pockets Related to Chronic Periodontitis Patients Using 16s RNA Metagenomics Sequencing
The study was developed in compliance with the Helsinki Declaration on medical research involving the Ethics Committee at Ajman University (2017-A-DN-04).
- Trial name
- NCT04425343
- Testing
- 16s RNA Metagenomics sequencing
- Where
- United Arab Emirates
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ajman University
Polycystic Ovary Syndrome, Chronic Periodontitis
Chronic Periodontitis and Polycystic Ovary Syndrome
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic…
- Trial name
- NCT02954120
- Testing
- no intervention provided
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Periodontitis, Rheumatoid Arthritis
Chronic Periodontitis and Tooth Loss in Patients With Rheumatoid Arthritis
Periodontitis is a highly prevalent chronic inflammatory disease that is characterized by loss of the periodontal ligament and alveolar bone, and is a major cause of tooth loss.
- Trial name
- NCT02441920
- Volunteers
- 400 people
- Sponsor
- University of Birmingham
Periodontitis, Prediabetes
Metabolic Effects of Treatment of Chronic Periodontitis in Non-diabetic Subjects
This study was aimed at assessing the effects of non-surgical periodontal treatment (NSPT) of chronic periodontitis on insulin sensitivity, glucose tolerance, and serum C-reactive protein(CRP) level amongst non-diabetic subjects.
- Trial name
- PARODIA2 (NCT02830113)
- Testing
- non-surgical periodontal treatment
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yaounde Central Hospital
Periodontitis, Adult
Non-surgical Periodontal Treatment in Smokers on SIRT-1, NLRP3 Inflammasome and LncRNAs
The goal of this observational is to analyze the relationship between levels of interleukin-18 (IL-18), interleukin (IL-1β), Tumor Necrosis Factor-alpha (TNF-α), interleukin-10 (IL-10), transforming growth factor beta (TGF-β)…
- Trial name
- NCT06351722
- Testing
- Before non-surgical periodontal treatment, non-surgical periodontal treatment, 3rd month after non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis, Periodontal Inflammation
Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis
For proving the potential of tropical medicaments on clinical parameters of periodontitis, a comprehensive assessment is required between therapeutic medicaments.
- Trial name
- NCT04964167
- Testing
- Plant extract
- Where
- 2 sites in Pakistan, Saudi Arabia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University