Clinical trials: Adult Periodontitis
Periodontitis
Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis
Background: Aloe vera is considered to be the most promising and high-ranking agent as an all-purpose herbal plant amongst herbal agents used in dentistry.
- Trial name
- NCT02462993
- Testing
- Aloe Vera
- Volunteers
- 12 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Chronic Kidney Disease, Chronic Periodontitis, Generalized, Moderate
Dental Intervention Plan for Chronic Kidney Disease Patients Awaiting or With Kidney Transplant
The study aims to understand why dental infections in end-stage kidney patients results in poor outcomes for kidney functions and eventually transplant.
- Trial name
- NCT04020458
- Testing
- dental intervention
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Augusta University
Chronic Periodontitis, Smoking, Cigarette
GCF IL-17 Levels and Oxidative Status of Smoking and Non-smoking Individuals With Periodontitis
This study was performed to evaluate the effects of both periodontal treatment and smoking on the gingival crevicular fluid(GCF) levels of interleukin (IL)-17A, IL-17E, Total oxidative stress(TOS) and total antioxidant…
- Trial name
- GCF (NCT04115176)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ondokuz Mayıs University
Chronic Periodontitis
Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favourable effect on alveolar bone.
- Trial name
- NCT03204058
- Testing
- Rosuvastatin, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Diseases
Periostin and Non-Surgical Periodontal Treatment
A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment.
- Trial name
- NCT04332965
- Testing
- Non-Surgical Periodontal Treatment
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Chronic Periodontitis, Depression
Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis
This study will evaluate whether use of antidepressants can reduce gingival inflammation in patients with periodontal (gum) disease.
- Trial name
- NCT03553095
- Testing
- Periodontal Surgery
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
-Chronic Periodontitis
Efficacy of Oral Probiotic Administration in Patients With Chronic Periodontitis
The aim of this randomized placebo- controlled clinical trial is to evaluate the effects of Lactobacillus rhamnosus SP1- containing probiotic tablets as an adjunct to scaling and root planning (SRP).
- Trial name
- probiotic (NCT02283736)
- Testing
- Lactobacillus rhamnosus SP1, Talc powder, Periodontal treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Jorge Gamonal
Chronic Periodontitis
Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal Pockets
Background: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume…
- Trial name
- NCT02531555
- Testing
- 810 Nanometer Wavelenght GaAlAs Diode Laser, Gracey curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Periodontitis, Adult, Smoking
Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease
The goal of this observational study is to evaluate if the measurement of salivary Interleukin (IL)-39, IL-41, IL-1Beta(β), and Tumor necrosis factor-alpha (TNF-α) levels can aid in the early diagnosis of periodontitis in…
- Conditions
- Periodontitis, Adult, Smoking, Periodontal Diseases
- Trial name
- NCT06528522
- Testing
- Clinical Measurements and Saliva Sample Collection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis, Diabetes Mellitus
Effects of Gum Disease Treatment on Host Defense Factors
Human immune system produces many different factors, which will influence health-disease statuses. This partially explains why under similar conditions only some people become sick.
- Trial name
- PETREBED (NCT03146975)
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Periodontitis
IL-32 Levels in Patients With Chronic Periodontitis
Interleukin-32 (IL-32) is a recently described cytokine that is a strong inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α.
- Trial name
- NCT02632981
- Testing
- nonsurgical periodontal treatment, Gingival crevicular fluid and saliva collection
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontitis
Prevalence of Periodontitis on a Sample of Adult Egyptian Population
Observational cross-sectional study
- Trial name
- NCT03901911
- Volunteers
- 1,708 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Clinical and Microbiological Effects
Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis.
Background: Peridontitis is a group of diseases with complex bacterial etiology that affects a large proportion of the Chilean and worldwide population.
- Trial name
- Metro + Amoxi (NCT01211223)
- Testing
- Administration of Metronidazole plus Amoxicillin
- Where
- Chile
- Volunteers
- 42 people
- Sponsor
- University of Chile
Chronic Periodontitis, Generalized
The Effects of Periodontal Therapy on Glycemic Control in Diabetic Patients
Is the non-surgical periodontal therapy can improve glycemic control in type 2 diabetic patients with chronic periodontitis?
- Trial name
- NCT03783845
- Testing
- amoxicillin 500mg and metronidazole 400mg
- Volunteers
- 44 people
- Sponsor
- Taibah University
Chronic Periodontitis, Aggressive Periodontitis
Nitro-oxidative Stress in Periodontitis
Periodontitis is a chronic inflammatory disease whose etio-pathogencity is not fully understood yet. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in physiological and pathological processes.
- Trial name
- NCT02127203
- Where
- Syria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damascus University
Chronic Periodontitis
Clinical Trial of PeriZone PerioPatch in Subjects With Chronic Periodontitis
The purpose of this study is to determine if a topical, adhesive patch (PeriZone PerioPatch) applied to the gums after a deep tooth cleaning (scaling and root planing) reduces the signs of advanced gum disease (chronic…
- Trial name
- NCT01808703
- Testing
- PeriZone PerioPatch, Scaling and root planing alone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- MIS Implant Technologies, Ltd
Periodontitis, Adult
Full Mouth Ultrasonic Debridement Carried Out Either by Piezoelectric or Magnetostrictive Device
Treatment of periodontitis requires removal of dental biofilm both through professional mechanical plaque removal and domiciliar oral hygiene procedures.
- Trial name
- NCT05279950
- Testing
- Full-mouth ultrasonic debridement with piezoelectric device (EMS, mini piezon), Full-mouth ultrasonic debridement with magnetostrictive device (Cavitron Select, Dentsply)
- Where
- Italy
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Siena
CHRONIC PERIODONTITIS
Efficacy of AloeVera Gel Gum Massaging and Adjunct to Scaling and Root Planing in Chronic Periodontitis Patients
Periodontal disease is a multifactorial disease caused by mainly bacterial, genetic, immunologically, and environmental factors.
- Trial name
- NCT03083535
- Testing
- Tooth Brushing, aloe vera Massaging, SRP with aloe vera massaging
- Volunteers
- 120 people
- Sponsor
- Government College of Dentistry, Indore