Clinical trials: Adult Periodontitis
Chronic Periodontal Disease
Effect of Baduanjin Exercise on Chronic Periodontal Disease in Elderly
The metabolic syndrome (MetS) is a spectrum of conditions that increase the risk of cardiovascular disease and diabetes mellitus.
- Trial name
- NCT05484479
- Testing
- Baduanjin training/exercise
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Chronic Periodontitis, Cardiovascular Diseases
NSPT on Calprotectin and Periostin Levels
Periodontitis is a chronic inflammatory disease is initiated by the oral microbial biofilm where in the response to this infection is mediated by various intracellular signalling pathways leading to the production of numerous…
- Conditions
- Chronic Periodontitis, Cardiovascular Diseases, Periodontal Inflammation
- Trial name
- NCT05618743
- Testing
- Non Surgical Periodontal Therapy
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Menopause
Assessment of Neopterin Levels in Pre- and Post-menopausal Women With Chronic Periodontitis
Neopterin is an early and valuable biomarker of cellular immunity, shown to be a sensitive assessment parameter for cell-mediated immune reactions.
- Trial name
- NCT04141033
- Testing
- assessment of neopterin levels
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Asymptomatic Apical Periodontitis
Effect of Calcium-Based Bioceramic Sealer and Resin-Based Sealer on Postoperative Pain
This study aims to compare the effect of calcium-based bioceramic sealer and resin-based sealer on postoperative pain in adult patients with asymptomatic apical periodontitis undergoing root canal treatment.
- Trial name
- NCT07256691
- Testing
- Resin-based sealer obturation technique, Bioceramic sealer obturation
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Fatima Memorial Hospital
Periodontitis
Role of Simvastatin Microsponges in Treatment of Periodontitis
the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentially absorbed.
- Trial name
- NCT04836078
- Testing
- open flap subgingival debridement, Subgingival injection of chitosan 2% gel
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Three Wall Intrabony Defects in Chronic Periodontitis
Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis
The purpose of the present study was to investigate the efficacy of autologous Platelet rich fibrin (PRF) or PRF and Simvastatin (SMV) with open flap debridement (OFD) in the treatment of three wall intrabony defects in…
- Trial name
- NCT02120872
- Testing
- Platelet rich fibrin and simvastatin, Platelet rich fibrin, Open Flap Debridement alone
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Teh Effect of Subgingival Irrigation Wif Ketorolac and Chlorhexidine in Patients Wif Chronic Periodontist
In this study, 40 patients with a history of Mild- Periodontitis who were diagnosed with clinical and radiographic findings showed that all of the periodontal parameters before the treatment, during the treatment period Then…
- Trial name
- NCT03836781
- Testing
- Ketorolac, Chlorhexidine 2%
- Where
- Iran
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Amirhossein Farahmand
Periodontal Diseases
Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation
Non-surgical treatment of chronic periodontitis with vitamin E and coenzyme Q10 supplementation
- Trial name
- NCT06373848
- Testing
- Receive 30 mg of Coq10
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Chronic Periodontitis
Role of Infected Blood Dendritic Cells in Heart Disease Risk
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
- Trial name
- NCT01568944
- Testing
- Oral Antibiotic and Oral Rinse, Standard Treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Augusta University
Periodontitis
Correlation Between Periodontitis and Hypertension Among a Sample of Adult Egyptian Patients
The study is a cross-sectional study investigating the correlation between periodontitis and both hypertension and body mass index among a sample of adult Egyptian dental patients attending diagnostic center at faculty of…
- Trial name
- NCT04634734
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis
Effect of Root Planing on Surface Topography.
In a clinical trial of 19 patients, 44 single-rooted teeth will be randomly assigned to one of four groups for: 1) no treatment, 2) manual root planing with curettes; 3) root planing with piezoelectric ultrasonic scraper [PU]; or…
- Trial name
- NCT01945632
- Testing
- conventional gracey curettes, Vertically oscillating ultrasonic device, piezoelectric ultrasonic scraper
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Universidad de Granada
Periodontal Disease
Genetics of Periodontal Diseases in Chinese (Taiwan)
A retrospective case control study to validate the association between Interleukin-1 gene variations and adult chronic periodontal disease in Chinese (Taiwan).
- Trial name
- NCT01675336
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Non-steroidal Anti-inflammatory Poisoning
Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic…
- Trial name
- NCT02658799
- Testing
- cataflam (diclofenac potassium)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Baskent University
Chronic Periodontitis, End Stage Renal Disease
Novel PAradigm to Improve Inflammatory Burden in ESRD (rePAIR): A Pilot and Feasibility Randomized Controlled Trial
The goal of this project is to assess repeated and ongoing oral care and the way it may affect inflammation and quality of life in hemodialysis patients.
- Trial name
- rePAIR (NCT03241511)
- Testing
- Test
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- UConn Health
Periodontal Disease : Chronic Periodontitis
Antimicrobial Peptides in Periodontitis
Periodontal diseases are complex chronic pathologies presenting a high prevalence worldwide. Etiopathological process involved in initiation and progression of these multifactorial diseases are not well understood, explaining the…
- Trial name
- PAROPAM (NCT02793453)
- Testing
- periodontal smears
- Where
- France
- Volunteers
- 29 people
- Sponsor
- CHU de Reims
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Alveolar Bone Loss
Vitamin D and Periodontitis
Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation.
- Trial name
- NCT03088488
- Testing
- fasting venous blood samples
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ordu University
Chronic Periodontitis
Adjunctive Photodynamic Therapy in the Treatment of Chronic Periodontitis
The aim of this randomized clinical trial is to clinically evaluate the effectiveness of the adjunctive use of photodynamic therapy (PDT) with an light-emitting diode (LED) light source in the treatment of chronic periodontitis.
- Trial name
- NCT01330082
- Testing
- Adjunctive Photodynamic Therapy, Light-emitting diod Irradiation, applying Photosensitizer
- Where
- Iran
- Volunteers
- 16 people
- Sponsor
- Tehran University of Medical Sciences