Clinical trials: Adult-onset Diabetes
Obesity Type 2 Diabetes Mellitus
Fecal Microbiota Transplantation (FMT) Combined With Calorie-Restricted Diet and Semaglutide in Patients With Obesity and Type 2 Diabetes
Investigation of the efficacy of fecal microbiota transplantation added to calorie-restricted diet and semaglutide versus calorie-restricted diet and semaglutide alone for weight loss and metabolic improvement in patients with…
- Trial name
- NCT07599046
- Testing
- Fecal microbiota transplantation (FMT), Semaglutide (1 Mg Dose), Calorie-restricted diet
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Type2 Diabetes, Cognitive Impairment
The Effect of SGLT2 Inhibitors on Cognitive Functions and BDNF Levels in Patients With Type 2 Diabetes
Cognitive impairment is a common complication in diabetes for various reasons. Although glycemic control improves cognitive impairment, different antidiabetic medications' effects on cognitive functions are still being…
- Trial name
- NCT05341388
- Testing
- MOCA cognitive evaluation test, BDNF levels, SF-36 test
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Goztepe Training and Research Hospital
Type 2 Diabetes, Endothelial Dysfunction
Vildagliptin and Endothelium-dependent Vasodilatation
Rationale: Cardiovascular complications in type 2 diabetes are the leading cause of morbidity and mortality associated with the disease. Endothelial dysfunction is regarded as an important factor in these vascular complications.
- Trial name
- NCT01000688
- Testing
- vildagliptin + acarbose, acarbose + vildagliptin
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 2
Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy
To determine whether use of detemir compared to neutral protamine hagedorn (NPH) decreases rates of composite neonatal outcome and maternal hypoglycemia events in women with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- Determin (NCT03620890)
- Testing
- Neutral Protamine Hagedorn (NPH), Detemir insulin
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity, Diabetes
Hypothalamic Function Before and After Bariatric Surgery
The purpose of this study is to determine the effect of gastric banding or gastric bypass on hypothalamic morphology and function, gut hormones and systems biology in obese subjects with and without type 2 diabetes.
- Trial name
- NCT01167959
- Testing
- Roux en Y gastric bypass and lap. gastric banding, Prodimed dietary intervention
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Type 2 Diabetes
A Study to Demonstrate the Bioequivalence of Sitagliptin/Metformin Combination Tablets and Co-administration of Sitagliptin and Metformin as Individual Tablets (0431A-095)
A three part study to demonstrate the bioequivalence of a single dose of the Final Market Image (FMI) of sitagliptin/metformin 50/500, 50/850 and 50/1000 mg Fixed-Dose Combination (FDC) tablet and co-administration of…
- Trial name
- NCT00961480
- Testing
- sitagliptin phosphate (+) metformin hydrochloride, Comparator: metformin 500mg, Comparator: sitagliptin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
The Effects of Hypoglycaemia in People With Type 2 Diabetes
Strict glycaemic control has been associated with increased hypoglycaemia and mortality rate, the cause of which was unclear, in subjects with type 2 diabetes.
- Trial name
- NCT02205996
- Testing
- Insulin (Humulin S), Euglycaemic Hypoglycaemic Insulin clamp
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Hull
Diabetes, Diabetes Mellitus, Type 2
The Efficacy of Insulin Degludec/Liraglutide as add-on Therapy in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on Sulphonylurea With or Without Metformin Therapy
This trial is conducted in Asia, Europe and the United States of America (USA). The aim of this trial is to investigate the efficacy and safety of insulin degludec/liraglutide in insulin naïve subjects inadequately controlled…
- Trial name
- DUAL™IV (NCT01618162)
- Testing
- insulin degludec/liraglutide
- Where
- 87 sites in United States, Bulgaria and 6 more
- Volunteers
- 435 people
- Sponsor
- Novo Nordisk A/S
Type2 Diabetes, Diabetes Mellitus, Type 2
Integration of Health Coaching and Diabetes Education in Type 2 Diabetes Mellitus Management at Primary Health Care
Type 2 Diabetes Mellitus is a chronic disease with increasing incidence globally. It needs a comprehensive and continuous management approach that includes five pillars: education, nutritional management, physical activity…
- Conditions
- Type2 Diabetes, Diabetes Mellitus, Type 2, Endocrine System Diseases, Nutritional and Metabolic Diseases
- Trial name
- NCT05090488
- Testing
- Personal Health Coaching and Diabetes Education in Group
- Where
- Indonesia
- Volunteers
- 200 people
- Sponsor
- Universitas Indonesia
Type 2 Diabetes Mellitus
A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005)
This study will assess the safety, tolerability and glucose-lowering efficacy of MK-0893 in participants with type 2 diabetes mellitus.
- Trial name
- NCT02004886
- Testing
- MK-0893, Metformin
- Volunteers
- 74 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus, Obesity
Effects of Rosiglitazone on Serum Ghrelin and Peptide YY Levels
We aimed to evaluate the effects of rosiglitazone on serum ghrelin and peptide yy levels in diabetic women.
- Trial name
- NCT00522470
- Testing
- rosiglitazone
- Where
- Turkey (Türkiye)
- Sponsor
- Baskent University
Diabetes Mellitus, Type 2
A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)
The purpose of this study is to learn about the safety and if people tolerate a study medicine called MK-1403. The study will also measure what happens to MK-1403 in the body of a person with type 2 diabetes (T2D) over time…
- Trial name
- NCT07242469
- Testing
- MK-1403 + additive coformulation
- Where
- 5 sites in United States
- Volunteers
- 53 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 1 Diabetes, Type 2 Diabetes
Exercise and Diabetes - an Observational Study of Exercise and Blood Glucose Control
This proposal seeks to gather continuous blood glucose and physical activity data from individuals with and without diabetes.
- Trial name
- NCT02190669
- Testing
- exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Diabetes Mellitus
Exubera vs Lispro in a Lantus-based Regimen for Improved Glycemic Control in Type 2 Diabetes
The current trial will examine the efficacy and safety of Exubera administered as a mealtime insulin compared to lispro, when added to an existing regimen of basal insulin glargine + or = Oral Agents (OAs).
- Trial name
- NCT00348374
- Testing
- Insulin Lispro, Exubera
- Where
- 63 sites in United States, Puerto Rico
- Volunteers
- 191 people
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2, PreDiabetes
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease.
- Conditions
- Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
- Trial name
- TRANSFORM (NCT06112418)
- Testing
- The Cleerly CAD Staging System
- Where
- 125 sites in United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Cleerly, Inc.
Type 2 Diabetes
The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients
Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2…
- Trial name
- NCT01127997
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- The Catholic University of Korea
Type 2 Diabetes Mellitus, Hyperglycemia Due to Type 2 Diabetes Mellitus
NMES, Exercise, and Glycemic Control in Older Adults With Type 2 Diabetes
Adults aged 60 years and older with type 2 diabetes living in nursing homes may experience difficulty participating in conventional exercise programs because of frailty, mobility limitations, or chronic health conditions.
- Conditions
- Type 2 Diabetes Mellitus, Hyperglycemia Due to Type 2 Diabetes Mellitus, Aging
- Trial name
- NMES4GlyCon (NCT06856720)
- Testing
- Neuromuscular Electrical Stimulation, Combined Aerobic and Resistance Exercise, Health Literacy Education
- Where
- Portugal
- Volunteers
- 75 people
- Sponsor
- University of Salamanca
Type 2 Diabetes
Mechanisms of Diabetes Relapse After Bariatric Surgery
The objective of this study is to investigate the different mechanisms by which Gastric Bypass (GBP), laparoscopic adjustable gastric banding (LAGB) and vertical sleeve gastrectomy (VSG) affect glucose control.
- Trial name
- LAF26 (NCT01516320)
- Testing
- Roux-en-Y Gastric Bypass, Laparoscopic adjustable gastric banding, Vertical Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Blandine Laferrere
Blood Flow
The Role of GIP in Postprandial Splanchnic Blood Flow Distribution and Metabolism in Patients With Type 2 Diabetes
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in…
- Trial name
- GA-17b (NCT06426823)
- Testing
- GIPR antagonist / study tool
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Copenhagen
Diabetes Mellitus, Non Insulin Dependent Diabetes Mellitus
ED Diabetes Screening and Outpatient Care - Aim 3
This goal of this NIH funded R01 study is to identify risk factors for not being able to follow-up for a new diagnosis of diabetes in the emergency department and improve linkage of these newly diagnosed patients to appropriate…
- Trial name
- NCT05899023
- Testing
- Telehealth Bridge Visits, Standard of Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health