Clinical trials: Adults With Overweight and Obesity
Asthma, Allergic, Asthma
IL13 Signaling in Allergic Asthma
This study will investigate the role of dupilumab in the treatment of asthma with comorbid obesity. It is hypothesized that in airway epithelial cells, unique transcriptomic and proteomic expression patterns distinguish allergic…
- Conditions
- Asthma, Allergic, Asthma, Obesity
- Trial name
- NCT05478824
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
COVID-19, Chronic Heart Failure
Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection
Depersonalized multi-centered registry initiated to analyze dynamics of non-infectious diseases after SARS-CoV-2 infection in population of Eurasian adult patients.
- Conditions
- COVID-19, Chronic Heart Failure, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- ACTIV4 (NCT05226416)
- Where
- Russia
- Volunteers
- 3,554 people
- Sponsor
- Eurasian Association of Therapists
Obesity, Metabolic Syndrome
Rutazyme Lemon Fermented Product Capsules for Metabolic Function in Adults With Obesity
This study evaluates whether a fruit- and vegetable-based fermented product (Rutazyme® lemon fermented product) taken as a capsule can improve metabolic health in adults with obesity.
- Trial name
- NCT07540949
- Testing
- Rutazyme® Lemon Fermented Product Capsule
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan Sport University
Prediabetes, Hyperglycemia
β-alanine Supplementation in Adults With Overweight/Obesity
The study will investigate the safety, feasibility, and efficacy of beta-alanine supplementation in adults with overweight or obesity.
- Conditions
- Prediabetes, Hyperglycemia, Overweight or Obesity
- Trial name
- BASA-O (NCT05329610)
- Testing
- Beta-alanine
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nottingham Trent University
Obesity
Cinnamon and Withania on Weight Loss
With the prevalence of obesity soaring and the absence of an effective and safe treatment that is low-cost and always feasible, the use of food supplements has gained attention for the potential benefits in the absence of…
- Trial name
- NCT05210218
- Testing
- Cinnamomum cassia (CC) and Withania somnifera (WS) (300 mg+150mg, respectively)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Roma La Sapienza
Obesity
Predicting Appendicular Lean and Fat Mass With Bioelectrical Impedance Analysis Among Adult Patients With Obesity.
This study aims to develop and cross-validate novel bioelectrical impedance analysis (BIA) equations for predicting appendicular soft tissue masses, specifically fat mass (FM) and appendicular lean mass (ALM), in a sample of…
- Trial name
- NCT06545435
- Where
- 9 sites in United States, Australia and 4 more
- Volunteers
- 400 people
- Sponsor
- University of Roma La Sapienza
Metabolic Dysfunction-Associated Steatotic Liver Disease, MASLD
Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
This study will test a Regeneron study drug called ALN-CIDEB to find out whether it may help treat a liver disease called metabolic dysfunction-associated steatohepatitis (MASH).
- Trial name
- NCT07854782
- Testing
- ALN-CIDEB
- Where
- 4 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Regeneron Pharmaceuticals
Dyslipidemia, Obesity & Overweight
Impact of Dyslipidemia on Metabolic Health of Adults With Overweight/Obesity (IDOM): A Study at the San Raffaele Hospital Center for Metabolic Health
A single-center, retrospective, observational study without experimental intervention, conducted at the Center of Excellence for Metabolic Health at IRCCS San Raffaele Hospital.
- Trial name
- IDOM (NCT07919158)
- Where
- Italy
- Volunteers
- 900 people
- Sponsor
- Rovere Querini Patrizia
Obese Adults
Evaluation of the Effects of Systemic Vibration Therapy on Thermogenesis, Cardiovascular Parameters, Endocrine-inflammatory Markers, and Physical-functional Performance in Adults With Obesity.
The goal of this clinical trial was to evaluate the effects of Systemic Vibration Therapy (SVT) on thermogenesis, cardiovascular health, endocrine-inflammatory markers, and physical performance in adults (men and women, aged…
- Trial name
- SVT (NCT07729215)
- Testing
- Systemic vibratory therapy, Systemic vibration therapy
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Laboratorio de Vibraçoes Mecanicas e Praticas Integrativas
Obesity
Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
The primary objective of this study is to describe the single- and multiple-dose pharmacokinetic profiles of two novel formulations of topiramate and commercially available immediate release topiramate, all dosed with immediate…
- Trial name
- NCT00518466
- Testing
- topiramate, phentermine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Obesity
Creation of Side-to-Side Compression Anastomosis Using the Magnetic Anastomosis System
This is an operationally seamless, open-label, multicenter study enrolling up to 50 subjects with obesity and with or without type 2 diabetes at up to 5 study centers across Canada and Europe who will undergo sleeve gastrectomy…
- Trial name
- NCT05322122
- Testing
- Side-to-side anastomosis duodeno-ileostomy diversion procedure
- Where
- 4 sites in Belgium, Canada and 2 more
- Volunteers
- 49 people
- Sponsor
- GT Metabolic Solutions, Inc.
Metabolic Syndrome
Effects of Walnuts on Endothelial Function in Overweight Adults With at Least One Factor of Metabolic Syndrome
The purpose of this study is to examine the effects of walnut consumption on endothelial function and lipid markers in overweight patients with at least one factor of metabolic syndrome as compared to the control group.
- Trial name
- Walnut2 (NCT01413646)
- Testing
- Walnut Supplementation, No walnut supplementation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Griffin Hospital
Obesity, Sarcopenia
Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity
The primary objectives of the present study are to estimate the sarcopenic proportion in a cohort of obese older subjects who have been hospitalized.
- Trial name
- PREFISAR (NCT06299241)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Morbid Obesity
Comparing Dumping Symptoms and Quality of Life 6 Months After Sleeve Gastrectomy With or Without Transit Bipartition in Adults With Obesity
This clinical study aims to compare two types of bariatric (weight loss) surgery used to treat obesity: sleeve gastrectomy alone and sleeve gastrectomy with transit bipartition.
- Conditions
- Obesity, Morbid Obesity, Dumping Syndrome, Postgastrectomy Syndrome
- Trial name
- STuD-QoL (NCT07263269)
- Testing
- Sleeve Gastrectomy, Sleeve Gastrectomy with Transit Bipartition
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mina Kamal Gergis Erian
Overweight, Obesity
Transcutaneous Auricular Vagus Nerve Stimulation Combined With Lifestyle Intervention for Visceral Fat Reduction in Adults With Overweight or Obesity
This is a single-center, randomized, open-label controlled trial with blinded outcome assessment and data analysis. Fifty adults with overweight or obesity (body mass index [BMI] >= 24 kg/m2) and a sedentary lifestyle will be…
- Trial name
- taVNS (NCT07907029)
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS), Standardized lifestyle program (calorie-restricted diet plus aerobic exercise)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Guangdong Provincial Hospital of Traditional Chinese Medicine
Obesity, Overweight With Indications for Weight Loss
Optimizing Body Composition for Function in Older Adults
The purpose of this pilot study is to compare two strategies intended to improve the health of overweight older adults by improving body composition.
- Trial name
- NCT00315146
- Testing
- Pioglitazone, Resistance exercise training to maximize muscle power, Hypocaloric diet
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Sleep, Body Composition
Impact of Protein Quantity Within the USDA Healthy Style Eating Pattern on Sleep
This evaluates the affect of protein quantity on indices of sleep. Half the participants will be prescribed protein in the amount consistent with the USDA healthy style eating pattern, while the other half will be prescribed a…
- Trial name
- NCT03174769
- Testing
- Normal protein, High protien
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Purdue University
Obesity, Overweight
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase.
- Trial name
- ENLIGHTEN-1 (NCT07321886)
- Testing
- Eloralintide
- Where
- 158 sites in United States, Argentina and 13 more
- Volunteers
- 1,980 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder)
Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy
The goal of this clinical trial is to learn whether adding the NutriSteppe digital dietary intervention to routine medical care improves metabolic health in adults aged 21 to 65 years with type 2 diabetes mellitus, obesity, or…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Obesity (Disorder), Overweight, Metabolic Syndrome
- Trial name
- NutriSteppe (NCT07728669)
- Testing
- NutriSteppe Digital Dietary Intervention
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- Kazakh Academy of Nutrition
Hypertriglyceridemia, Overweight , Obesity
Standardized Large Yellow Tea Extract for Glucose and Lipid Metabolism in Overweight Adults With Hypertriglyceridemia
This multicenter, prospective, randomized, blinded, parallel-group controlled trial will evaluate the effects of standardized large yellow tea extract on glucose and lipid metabolism in overweight adults with elevated…
- Trial name
- NCT07840846
- Testing
- Standardized Large Yellow Tea Extract
- Volunteers
- 138 people
- Sponsor
- The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial)