Clinical trials: Advanced Chronic Heart Failure
Chronic Heart Failure
Singapore Cohort of Patients with Advanced Heart Failure
Chronic Heart Failure (CHF) is one of the leading causes of death in Singapore. Although it is well established that CHF patients in Singapore are less likely to be referred to palliative care services than cancer patients…
- Trial name
- SCOPAH (NCT03089034)
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- Duke-NUS Graduate Medical School
Dyspnea, Respiratory Insufficiency
Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease
Episodic breathlessness is a common and distressing symptom in patients with advanced disease such as cancer, chronic obstructive pulmonary disease (COPD) and chronic heart failure.
- Conditions
- Dyspnea, Respiratory Insufficiency, Neoplasms, Pulmonary Disease, Chronic Obstructive
- Trial name
- CoBeMEB (NCT04630743)
- Testing
- Cognitive and Behavioral intervention for the Management of Episodic Breathlessness
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Cologne
Heart Failure
V-Lap System For Wirelessly Measuring And Monitoring Left Atrial Pressure (LAP) In Patients With Advance Chronic Heart Failure
The objective of this study is to evaluate the safety and performance of the V-LAP System in subjects with New York Heart Association (NYHA) functional class II and III HF, irrespective of left ventricular ejection fraction.
- Trial name
- NCT05448833
- Testing
- V-LAP™ SYSTEM
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Vectorious Medical Technologies Ltd.
Congenital Complete Atrioventricular Heart Block, High Grade Atrioventricular Block
Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block
Recent studies have shown that chronic stimulation of the right ventricle can cause deleterious effects to cardiac function and synchronicity.
- Conditions
- Congenital Complete Atrioventricular Heart Block, High Grade Atrioventricular Block, Postoperative Complete Heart Block
- Trial name
- NCT01477658
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo
Chronic Heart Failure
Evaluation of the HeartWare Left Ventricular Assist Device for the Treatment of Advanced Heart Failure
The purpose of this study is to evaluate the safety and effectiveness of the HeartWare® LVAD System in patients listed for cardiac transplantation with refractory, advanced heart failure at risk of death.
- Trial name
- ADVANCE (NCT00751972)
- Testing
- HeartWare® VAS
- Where
- 35 sites in United States
- Volunteers
- 140 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Congestive
ESSENTIAL-"The Studies of Oral Enoximone Therapy in Advanced Heart Failure"
To determine if low-dose enoximone therapy is an effective treatment for advanced chronic heart failure.
- Trial name
- NCT00051285
- Testing
- Enoximone
- Volunteers
- 1,800 people
- Sponsor
- Gilead Sciences
Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
Improving Clinician Communication Skills (ICCS)
This research study is a randomized trial to evaluate a training program that is designed to improve the communication skills of clinicians.
- Conditions
- Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD), Restrictive Lung Disease, Congestive Heart Failure
- Trial name
- ICCS (NCT00687349)
- Testing
- Training Program Intervention
- Where
- 4 sites in United States
- Volunteers
- 6,086 people
- Sponsor
- University of Washington
Hemodialysis, Ventriculo-arterial Coupling
Ventriculo-Arterial Coupling and Intra-Dialytic Changes in Hemodialysis Patients: Prognostic Insights
The acute effect of hemodialysis (HD) on left ventricular mechanics has been evaluated in several studies, however their results are not uniform.
- Trial name
- NCT06622928
- Testing
- Echocardiogram
- Where
- Kazakhstan
- Volunteers
- 384 people
- Sponsor
- Nazarbayev University
Heart Failure, Chronic Obstructive Lung Disease
Primary Care Management/Action Plans for Advanced Chronic Diseases
Patients living with advanced chronic diseases (ACD), such as congestive heart failure (CHF) and chronic obstructive lung disease (COPD) present substantial care and economic challenges for the health care system due to frequent…
- Trial name
- NCT00202150
- Testing
- Application of a management action plan
- Where
- Canada
- Volunteers
- 139 people
- Sponsor
- Queen's University
Heart Failure, Congestive
Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure
Beta-blocker medications have been shown to improve heart function and prolong the lives of patients with chronic heart failure (CHF).
- Trial name
- NCT00077948
- Testing
- Enoximone, Metoprolol succinate
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Gilead Sciences
Hepatitis C, Chronic, Heart Failure
Hepatitis C Virus(HCV) Heart and Lung Study
This is a multicenter study in Hepatitis C Virus (HCV) infected adult patients who also have advanced cardiac disease or advanced lung disease.
- Conditions
- Hepatitis C, Chronic, Heart Failure, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
- Trial name
- NCT02858180
- Testing
- Sofosbuvir/ledipasvir fixed dose combination(SOF/LDV FDC)
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Chronic Heart Failure, Hyperuricemia
Allopurinol in Chronic Heart Failure
The purpose of this study is to discover whether the inhibition of the xanthine oxidase with allopurinol leads to a reduction of the production of oxygen free radicals in patients with CHF and thereby improves characteristics of…
- Trial name
- NCT00997542
- Testing
- Allopurinol
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- National Heart and Lung Institute
Heart Failure
Impact of Socio Economic Limitations on Health Outcomes in Patients With Recent Admission for Heart Failure
To assess the impact of the socio-economic level on the effectiveness of a comprehensive multidisciplinary program of transitional care for crhonic heart failure patients (primary objective); to analyze this specifically in the…
- Trial name
- SELENE (NCT04022122)
- Testing
- Usual Care follow-up in a heart failure program.
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Hospital Universitari de Bellvitge
Breathlessness, COPD
Evaluation of a Multi-professional Breathlessness Service for Patients With Breathlessness Due to Any Advanced Disease
Breathlessness is a common and distressing symptom in patients with advanced diseases like cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF) or lung fibrosis, which broadly impacts on patients'…
- Conditions
- Breathlessness, COPD, Cancer, Chronic Heart Failure
- Trial name
- BreathEase (NCT02622412)
- Testing
- Multi-professional breathlessness service (MBS), Delayed MBS Intervention
- Where
- Germany
- Volunteers
- 183 people
- Sponsor
- Ludwig-Maximilians - University of Munich
ESRD, CKD Stage 4, CKD Stage 5
Canagliflozin in Advanced Renal Disease With MRI Endpoints
This is a phase II, proof of concept, placebo-controlled, randomized clinical trial, assessing the effect of canagliflozin on cardiac structure and function in patients with advanced renal disease, including those on maintenance…
- Trial name
- CARe-MRI (NCT06182839)
- Testing
- Canagliflozin 300Mg Tab
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Stable Heart Failure
Efficacy and Safety of Pulsed Infusions of Levosimendan in Outpatients With Advanced Heart Failure
The purpose of this study is to compare the effects of a pulsed application of Levosimendan versus placebo on the composite end-point functional capacity and quality of life.
- Trial name
- LevoRep (NCT01065194)
- Testing
- Levosimendan
- Where
- 11 sites in Austria, Greece
- Volunteers
- 120 people
- Sponsor
- Medical University Innsbruck
Advanced Chronic Heart Failure
ELEVATE Early LEvosimendan Vs Usual Care in Advanced Chronic hearT failurE
The purpose of this study is to compare in patients with Advanced Chronic Heart Failure the effects of Levosimendan versus diuretic (single 24-hour infusion) applied at the early detection of impending destabilization on…
- Trial name
- ELEVATE (NCT01290146)
- Testing
- Diuretics, Levosimendan
- Where
- 22 sites in Italy
- Volunteers
- 13 people
- Sponsor
- Niguarda Hospital
Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease
Advanced Respiratory Monitoring and Oxygen Therapy in Chronically Ill Patients With Acute Respiratory Failure
This study is testing whether a new type of home oxygen therapy, called high-flow nasal cannula (HFNC), can improve breathing comfort and quality of life for people with long-term lung or heart conditions who need oxygen after…
- Conditions
- Chronic Respiratory Failure, Cardiac Disease, Pulmonary Disease, Acute Respiratory Failure (ARF)
- Trial name
- HOME- Oxygen (NCT07157696)
- Testing
- High-Flow Nasal Cannula (HFNC) Oxygen Therapy, Oxygen therapy
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Università degli Studi di Ferrara
Chronic Heart Failure
Evaluation of Functionnal ElectromyoStimulation on Leg In Advanced Chronic Heart Failure After Hospitalisation for Acute Decompensation
The purpose of the study is to test the efficacy of the Functionnal ElectromyoStimulation (FES) of lower limbs in advanced chronic heart failure. The hypothesis is that FES treatment could improve functional exercise capacity.
- Trial name
- EMSICA (NCT01548508)
- Testing
- Functionnal ElectroStimulation (FES)
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Heart Failure With Reduced Ejection Fraction (HFrEF)
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
The primary purpose of the study is to evaluate the safety and efficacy of 2 doses of AC01 compared to placebo over 12 weeks in participants with chronic advanced HFrEF.
- Trial name
- GOAL-HF2 (NCT07584967)
- Testing
- AC01
- Volunteers
- 400 people
- Sponsor
- AnaCardio AB