Clinical trials: Advanced Cutaneous Squamous Cell Carcinoma
Cutaneous Squamous Cell Carcinoma, Squamous Cell Carcinoma
Cemiplimab/Peg-Interferon-α in Advanced CSCC
The primary purpose of this research study is to test the safety and possible harms of cemiplimab/peg-interferon-alpha, when it is given to participants at different dose levels.
- Conditions
- Cutaneous Squamous Cell Carcinoma, Squamous Cell Carcinoma, Advanced Squamous Cell Carcinoma
- Trial name
- NCT05729139
- Testing
- Cemiplimab-Rwlc, PEG-IFN alfa-2a
- Where
- United States
- Sponsor
- Baptist Health South Florida
Advanced Cutaneous Squamous Cell Carcinoma
Study of IBI318 in Patients With Advanced Cutaneous Squamous Cell Carcinoma
The purpose of this study is to evaluate the safety and efficacy of IBI318 (anti-PD-1/PD-L1) in adult participants with metastatic (nodal or distant) cutaneous squamous cell carcinoma (CSCC), or unresectable locally advanced CSCC…
- Trial name
- NCT04611321
- Testing
- IBI318
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Advanced Cancer, Gastric Cancer
Study Evaluating GZ17-6.02 in Patients With Advanced Solid Tumors or in Combination With Capecitabine in Metastatic Hormone Receptor Positive Breast Cancer
This Phase I/Ib study is a Multicenter, Open-label, Dose-Escalation, Safety, Pharmacodynamic and Pharmacokinetic Study of GZ17-6.02 Monotherapy and in Combination with Capecitabine, Given Orally on a Daily Schedule in Patients…
- Conditions
- Advanced Cancer, Gastric Cancer, Breast Cancer, Pancreatic Cancer
- Trial name
- GEN602 (NCT03775525)
- Testing
- GZ17-6.02, Capecitabine
- Where
- 4 sites in United States
- Volunteers
- 127 people
- Sponsor
- Genzada Pharmaceuticals USA, Inc.
Advanced or Metastatic Merkel Cell Carcinoma, Advanced or Metastatic Cutaneous Squamous Cell Carcinoma
Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors
This is a phase 1b/2, open-label, two-part, multicenter trial designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of intratumoral cavrotolimod injections alone and in…
- Conditions
- Advanced or Metastatic Merkel Cell Carcinoma, Advanced or Metastatic Cutaneous Squamous Cell Carcinoma, Advanced or Metastatic Melanoma, Advanced or Metastatic Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT03684785
- Testing
- Cavrotolimod, Pembrolizumab, Cemiplimab
- Where
- 26 sites in United States
- Volunteers
- 57 people
- Sponsor
- Exicure, Inc.
Advanced Cutaneous Squamous Cell Carcinoma
Nivolumab in Patients With Advanced Cutaneous Squamous Cell Carcinoma
Cutaneous squamous cell carcinoma (cSCC) is one of the most frequent malignancies worldwide, and an increasing incidence has been documented over the past decades.
- Trial name
- CA209-9JC (NCT03834233)
- Testing
- Nivolumab
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo