Clinical trials: Adverse Childhood Experience
Adverse Childhood Experiences
Journey of Hope in Appalachia: Supporting Resilience in the Region's Youth
Rural youth have heightened exposure to adverse childhood experiences (ACES) such as poverty, social isolation, chronic hunger, and drug use in the home.
- Trial name
- JOHA (NCT04096937)
- Testing
- Focus groups
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Gia Mudd
Adverse Childhood Experiences
Family Resilience Initiative Research Program
University Le Bonheur Pediatric Specialists (ULPS) and Le Bonheur Community Health and Well-Being, Maternal Child Department, have started the Family Resilience Initiative (FRI) in the ULPS General Pediatrics Clinic.
- Trial name
- NCT04018404
- Testing
- FRI CLINICAL PROGRAM
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
Healthy
Oxytocin Administration and Emotion Recognition Abilities in Adults Reporting Adverse Childhood Experiences
This study evaluates whether intranasal administration of a single dose of oxytocin improves the ability to recognize emotional states.
- Trial name
- NCT03335085
- Testing
- Oxytocin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults.
- Trial name
- NCT05665465
- Testing
- Nicotine nasal spray 0.5 mg
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Duke University
Mother to Child Transmission, Breast Feeding
Trauma-informed Obstetric Care for Perinatal Health: a Pilot Study
The study will test trauma-informed obstetric care training and supervision for obstetric clinicians in relation to prenatal mental health and attachment formation (early predictors of child development) in women presenting for…
- Conditions
- Mother to Child Transmission, Breast Feeding, Trauma
- Trial name
- NCT07195058
- Testing
- Trauma Informed Obstetric Care (TIOC)
- Where
- Argentina
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Adverse Childhood Experiences
Building Resilient Families
Prior research suggests that it is possible to improve health outcomes in children with ACEs through multi-component interventions.
- Trial name
- NCT05388864
- Testing
- Three-Tier Model
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Adverse Childhood Experiences
Increasing Use of Earned Income Tax Credit (EITC) in New Mexico
Purpose of the Proposed Project. The literature makes clear that poverty and financial hardship and lack of social support are significant risk factors that create a household environment conducive to Adverse Childhood…
- Trial name
- NCT04961177
- Testing
- EITC & ACEs Training, EITC Outreach & Screening, Assistance with EITC
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of New Mexico
Life Experiences
Effects of Exercise on Young Adult Women With ACEs: an Integrative Pilot Study
The process by which the body responds to stressors to maintain homeostasis is called allostasis and is dependent on the integrated function of the nervous, endocrine, and immune systems.
- Trial name
- NCT03521401
- Testing
- Exercise
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Adverse Childhood Experiences
The FACE Self-help App for Fostering Resilience
The FACE self-help app is an online intervention for young adults with Adverse Childhood Experiences (ACEs). It was developed based on well-established cognitive-behavioural therapy principles.
- Trial name
- NCT05824182
- Testing
- FACE self-help App
- Where
- Switzerland
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Jeannette Brodbeck
Chronic Pain, Adverse Childhood Experiences
Traumatic Events in Childhood, Attachment, Pain Perception, Epigenetic Marks, Quality of Life and Resilience.
In the present research study, aiming to explore the links between several psychological factors and chronic pain, the research seeks to develop an inclusive framework to investigate the role of adverse childhood experiences…
- Conditions
- Chronic Pain, Adverse Childhood Experiences, Attachment Styles, Chronic Stress
- Trial name
- NCT06077097
- Testing
- Biological samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University of Lorraine
Adverse Childhood Experiences, Endothelial Dysfunction
ACEs, SIRT1, and Premature Vascular Aging in Humans
Adverse childhood experiences (ACEs) are directly related to cardiovascular morbidity and mortality, and impaired vascular endothelial function (VEF) is an independent predictor of future cardiovascular disease (CVD) risk [1, 2].
- Trial name
- NCT07073352
- Testing
- Nicotinamide Riboside
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Perinatal Depression
Perinatal Depression and Adverse Childhood Experiences: Prevention Trial
The goal of this clinical trial is to evaluate the impact of ROSE in individuals with adverse childhood experiences. The main question it aims to answer is, compared to enhanced treatment as usual, does the delivery of ROSE…
- Trial name
- PPD-ACE (NCT05795114)
- Testing
- Reach Out, Stand Strong, Essentials for New Mothers (ROSE) Program
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Northwestern University
Fibrinogen Abnormality, Telomere Length, Mean Leukocyte
Pediatric ACEs Screening and Resiliency Study
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood.
- Conditions
- Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection
- Trial name
- PEARLS (NCT04182906)
- Testing
- Care Coordination, Resiliency Clinic, Usual Care
- Where
- United States
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Adverse Childhood Experiences, Cancer, Breast
Adverse Childhood Experiences, Adaptation and Breast Cancer
Adverse Childhood Experiences (ACEs) have long been linked to mental health problems in adulthood. In the case of cancer, no study has considered that such an anteriority could make patients more vulnerable emotionally, even…
- Conditions
- Adverse Childhood Experiences, Cancer, Breast, Attachment Styles, Resilience, Psychological
- Trial name
- CAPONE (NCT05843539)
- Testing
- Biological and epigenetic measures
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University of Lorraine
Chronic Pain, Trauma
Brief Intervention for Chronic Pain and History of Stressful Experiences
The goal of this study is to understand whether a brief, three session program can be helpful in reducing symptoms related to both chronic pain and stressful experiences/trauma.
- Conditions
- Chronic Pain, Trauma, Adverse Childhood Experiences
- Trial name
- NCT06983327
- Testing
- Trauma Focused Emotional Awareness and Expression Therapy (EAET)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Stress, Psychological Stress
Examine the Effects of Mindfulness in Woman With a History of Child Adversity
The aim of this pilot Randomized Controlled Trial (RCT) is to test whether brief mindfulness-based practices will improve well-being and health in women (age 30-50) with a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMA (NCT05255380)
- Testing
- Mindfulness and compassion-based practices; approximately 5-10 minutes two times/day, Mindful awareness and reporting of current thoughts and feelings, 2 times/day
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stress-related Problem, Stress, Emotional
Effects of Parent-Adolescent Joint I-Interventions for Adolescents with Adverse Childhood Experiences
The study aims to examine the effectiveness of internet-based Parent-Adolescent Joint Interventions in improving the mental health outcomes of participants, specifically by reducing symptoms of depression, anxiety, and PTSD, as…
- Trial name
- EASY-PEP-i (NCT06650696)
- Testing
- PCE promotion, Psychoeducation, Emotiaonl skill enhancement
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University
Adverse Childhood Experiences
The ACCEPT Study: Improving the Process of Disclosing Adverse Childhood Experiences in Community Mental Health
Experiences of abuse, neglect, domestic violence, severe bullying and community violence in childhood are very common among people who use mental health services.
- Trial name
- NCT06477380
- Testing
- ACCEPT intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King's College London
Pelvic Floor Disorders, Interstitial Cystitis
Adverse Childhood Experiences in Urogynecologic Patients
Adverse Childhood Experiences (ACEs) have been associated with negative health outcomes, yet scant information exists regarding the relationship between ACEs, Pelvic floor disorders, and Chronic Pelvic Pain.
- Conditions
- Pelvic Floor Disorders, Interstitial Cystitis, Urinary Incontinence
- Trial name
- ACE-UP (NCT03480477)
- Testing
- ACE questionnaire
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Multiple Sclerosis
Adverse Childhood Experiences in Patients With MS: Impact on Quality of Life and on Coping Strategies Towards the Disease and Its Treatment
The goal of this observational study is to evaluate the presence of adverse childhood experiences (ACE) in patients with Multiple Sclerosis.
- Trial name
- ACE-MS (NCT06718920)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS