Clinical trials: Adverse Childhood Experience
Child Abuse
Calling All Dads! Evaluation of APAs ACT Program: Engaging Fathers to Prevent Adverse Childhood Experiences
The goal of this observational study is to assess the American Psychological Association's ACT Raising Safe Kids program with male caregivers.
- Trial name
- CAD (NCT06075446)
- Testing
- ACT Raising Safe Kids
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Adverse Childhood Experiences, Mindfulness
Approaches That Support Mental Health in Post-secondary Students With Adverse Childhood Experiences
The objective of this study is to understand the prevalence of adverse childhood experiences (ACE) in students and to determine whether Mindfulness based stress resilience training (MBSR) is effective for promoting mental health…
- Conditions
- Adverse Childhood Experiences, Mindfulness, Students
- Trial name
- ACE (NCT03836456)
- Testing
- Mindfulness-based Stress Resilience Training, Health Enhancement Program
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Adverse Childhood Experiences, Developmental Risk
Growing Up in Multifactorial Risk Conditions
The perinatal period brings significant physiological and emotional changes in mothers, linked to pregnancy, childbirth, and caring for a newborn.
- Conditions
- Adverse Childhood Experiences, Developmental Risk, Psychomotor Development Disorders, Neurodevelopmental Disorders
- Trial name
- CORE (NCT07477899)
- Testing
- Home visiting programme
- Where
- Italy
- Volunteers
- 352 people
- Sponsor
- IRCCS Eugenio Medea
Adverse Childhood Experiences, Family Functioning
The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments
The goal of this 2-arm randomized control trial is to determine the impact of a community health worker delivered coaching intervention, GRIT, on preventing the early initiation of regular use of alcohol and cannabis among…
- Trial name
- NCT06821035
- Testing
- Garnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC)
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Infertility, Female, Trauma, Psychological
Adverse Childhood Experiences and Infertility : ACESI
Adverse childhood experiences can have powerful effects on health and quality of life in adulthood. Thus, having a history of childhood trauma, before the age of 18 (physical aggression, sexual abuse, death of a close person…
- Conditions
- Infertility, Female, Trauma, Psychological, Child Development, Child Abuse
- Trial name
- ACESI (NCT05952427)
- Testing
- ACE Questionnaire
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Infant Mortality, Infant Death
Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP)
This pilot project aims to implement and investigate the feasibility and acceptability of a unique community based prenatal care and support model for African American women and infants in Dane County.
- Conditions
- Infant Mortality, Infant Death, Racial Bias, Prenatal Stress
- Trial name
- NCT04100577
- Testing
- Today Not Tomorrrow Pregnancy and Infant Support Program
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alcohol Use Disorder, Trauma, Psychological
Adverse Childhood Experiences in Substance-related Disorders
Aversive childhood experiences (ACE) and their relation to the development of an alcohol use disorder will be measured with fMRI.
- Trial name
- NCT03758053
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Parent-Child Relations, Maternal Behavior
A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity
Childhood adversity affects almost two-thirds of the US population, is a major risk factor for the leading causes of disease and increases US economic health burdens.
- Conditions
- Parent-Child Relations, Maternal Behavior, Infant Behavior
- Trial name
- NCT04818112
- Testing
- ATVV, Attention control
- Where
- 2 sites in United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Myasthenia Gravis, Adverse Childhood Experience
Psychological Health and Adverse Childhood Experiences in Myasthenia Gravis: Online Mental Health BMI Learning Program
This study evaluated psychological health in patients with myasthenia gravis (MG) using an online behavioral program called the "Positive Mental Health BMI Learning Program." The program consisted of four short video units…
- Conditions
- Myasthenia Gravis, Adverse Childhood Experience, Psychological Well-being, Mental Well-being
- Trial name
- NCT07291713
- Testing
- Positive Mental Health BMI Learning Program
- Where
- Taiwan
- Volunteers
- 77 people
- Sponsor
- Jiann-Horng Yeh
Adverse Childhood Experiences, Housing Problems
Evaluation of the Building Healthy Life Skills Program
The goal of this intervention trial is to learn test whether participation in the Building Health Life Skills Program leads to improvements in psychological well-being and stress management skills for people who are experiencing…
- Conditions
- Adverse Childhood Experiences, Housing Problems, Emotion Regulation
- Trial name
- NCT05611060
- Testing
- Building Healthy Life Skills Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Merced
Mental Health Outcomes, Adverse Childhood Experiences
School Violence Exposure as an Adverse Childhood Experience
This study hypothesize that school safety strategies may contribute to poor mental health and distress among various school populations and proposes the following research questions to be answered through this study: 1.
- Conditions
- Mental Health Outcomes, Adverse Childhood Experiences, Perceived School Safety, Educational Outcomes
- Trial name
- NCT06153316
- Testing
- School shooting incident
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Teachers College, Columbia University
Autism Spectrum Disorder, Adverse Childhood Experiences
Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition
Using a metabolomics approach in combination with eye-tracking data, this research study proposes to gather evidence from two interrelated body systems (gut and brain) in order to assess how the microbiome is involved in stress…
- Conditions
- Autism Spectrum Disorder, Adverse Childhood Experiences, Stress Reaction
- Trial name
- NCT06269614
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Trauma and Stress-related Disorders, Food Insecurity
MISAPSY: Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults
The MISAPSY study (Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults) aims to model the complex interrelations between child…
- Conditions
- Trauma and Stress-related Disorders, Food Insecurity, Child Maltreatment, Psychological Distress
- Trial name
- PRESPA (NCT07427524)
- Testing
- Food Assistance, Psychological Follow-Up
- Where
- 6 sites in France
- Volunteers
- 70 people
- Sponsor
- University of Lorraine
Internet-Based Intervention
Evaluation of the First Pathways Game on Parent-child Interactions and Development for Vulnerable Children
Children's brains develop quickly in the first three years of life and are particularly sensitive to their environment. Adverse experiences, such as exposure to abuse and neglect, can increase children's risk for behavioral…
- Trial name
- NCT04902404
- Testing
- First Pathways Game
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Calgary
Adverse Childhood Experience, Endothelial Function (FMD)
Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity
Adverse childhood experiences (ACEs) represent highly stressful events in the first 18 years of life that include abuse, neglect, and household and community-level dysfunction.
- Conditions
- Adverse Childhood Experience, Endothelial Function (FMD), Endothelial Injury, Mitochondrial Function
- Trial name
- PROMISE (NCT07244809)
- Testing
- Mitoquinone mesylate (MitoQ)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Psychological Distress, Adverse Childhood Experience
EMI for Reducing Psychological Distress in Young Adults With Multiple ACEs: A Feasibility Study
This single-arm feasibility study aims to evaluate the feasibility and acceptability of an ecological momentary intervention (EMI) designed to reduce psychological distress among young adults with high levels of adverse childhood…
- Trial name
- NCT07823114
- Testing
- EMI
- Volunteers
- 20 people
- Sponsor
- Peking University
Adverse Childhood Experiences, Coronary Artery Disease
Adverse Childhood Experiences in Patients With Coronary Artery Disease Pilot
Adverse Childhood Experiences (ACEs) are potentially harmful events occurring during childhood that have been associated with chronic physical conditions in adulthood, including coronary artery disease (CAD).
- Trial name
- NCT04752228
- Testing
- Philadelphia ACE Survey, Lifestyle Assessment
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Menopause, Healthy Adult
Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health
The purpose of this study is to learn more about how estradiol patch treatment affects brain processes, health, and wellbeing.
- Conditions
- Menopause, Healthy Adult, Brain, Postmenopausal
- Trial name
- CEREBRA (NCT07831499)
- Testing
- Cyclic Estradiol, Continuous Estradiol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Weight Loss, Wait-List Control
Neurotrophic Indicators of Cognition, Executive Skills, Plasticity, and Adverse Childhood Experiences Study
Adverse childhood experiences (ACEs) are repeatedly shown to predict negative biopsychosocial health outcomes, including obesity.
- Trial name
- NICE SPACES (NCT04076722)
- Testing
- Stress reactivity stimuli
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Adverse Childhood Experiences
Facing Adverse Childhood Experiences
Childhood experiences affect psychosocial well-being and mental health across the life course for better or worse. The aim of the present study is to investigate how adverse childhood experiences before the age of 18 impact…
- Trial name
- FACE (NCT05122988)
- Where
- Switzerland
- Volunteers
- 2,606 people
- Sponsor
- University of Applied Sciences and Arts Northwestern Switzerland