Clinical trials: Adverse Drug Reaction
Adverse Drug Reactions
Collection, Evaluation and Assessment of Adverse Drug Reactions on the Oncology Ward
The proposed cohort study collected within a 5-month observation period adverse drug reaction (Adverse Drug Events - ADE) in patients at the Department of Oncology at the University of Zurich.
- Trial name
- NCT01058122
- Testing
- Collection of adverse drug events
- Where
- Switzerland
- Volunteers
- 129 people
- Sponsor
- University of Zurich
Poly Pharmacy, Frail Elderly
Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)
The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy…
- Trial name
- AMIDA-ICH (NCT07015112)
- Testing
- Patient-centered multidisciplinary treatment review
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Parc Sanitari Pere Virgili
Antifungal Drug Adverse Reaction
An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women
To evaluate the pharmacokinetics (PK) of EE and NES released from the CVR in the presence of a single dose and multiple doses of antimycotic co-medication (miconazole nitrate suppository or cream).
- Trial name
- NCT02215395
- Testing
- NES/EE CVR
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Population Council
Hypertension
Lacidipine in Medical Practice in Patients With Mild to Moderate Essential Hypertension
In order to confirm the proposed metabolic effect of lacidipine these follow-up study was to provide long-term data on its impact on liver function, glucose homoeostasis and lipid metabolism.
- Trial name
- NCT02177331
- Testing
- Lacidipine
- Volunteers
- 53 people
- Sponsor
- Boehringer Ingelheim
Adverse Drug Event
Improving Wisely - Polypharmacy
This is a randomized controlled trial that uses an audit and feedback intervention to alert primary care physicians who are outliers in one or more metrics related to high risk prescribing of participants' outlier status.
- Trial name
- NCT03857100
- Testing
- Audit and feedback - letter and report
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Johns Hopkins University
Pharmacogenetics, Drug-Related Side Effects and Adverse Reactions
Pharmacogenomics in Prediction of Cardiovascular Drugs Adverse Reaction
The research is planned as a prospective nested case-control study. The plan is to recruit about 1,200 consecutive subjects whose pharmacotherapy involves the drug(s) of interest within 4.5 years.
- Conditions
- Pharmacogenetics, Drug-Related Side Effects and Adverse Reactions, Cardiovascular Drugs
- Trial name
- NCT05307718
- Testing
- Oral Anticoagulant, Direct-Acting
- Where
- Croatia
- Volunteers
- 1,200 people
- Sponsor
- Clinical Hospital Centre Zagreb
Adverse Drug Event, Readmission
The Effect of a Pharmacist Home Visit on Drug-related Problems Post-discharge.
the purpose of this study is to determine the the effect of a home-based medication management program on drug-related problems post-discharge.
- Conditions
- Adverse Drug Event, Readmission, Patient Compliance
- Trial name
- HomeCoMe (NCT01897870)
- Testing
- HomeCoMe-program
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- H.T. Ensing, PharmD, MSc
Mycoses
Therapeutic Drug Monitoring of Voriconazole
The purpose of this study is to determine whether therapeutic drug monitoring of voriconazole is useful in the treatment of invasive fungal infection.
- Trial name
- NCT00890708
- Testing
- Voriconazole (therapeutic drug monitoring)
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Seoul National University Hospital
Multiple Sclerosis
VIGIP-SEP2: Training of Patients by Nurses on ADR Reporting by RRMS Patient Via an App
The patient's reporting of adverse drug reactions (ADRs) is recognized as being of interest for post-marketing safety monitoring, but is still underdeveloped in France, with an average lower than the European average.
- Trial name
- VIGIP-SEP2 (NCT04116424)
- Testing
- nurse training of the patient, neurologist accompaniement
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Caen
Metabolic Side Effects of Drugs
Studies of Sulfur Metabolism in Humans
The study test whether the NSAID allosteric site of human sulfotransferase 1A1 (SULT1A1) is operative in humans. The study will test the effects of mefenamic acid (MEF) on the sulfonation of acetaminophen (APAP, a SULT1A1…
- Trial name
- NCT03383133
- Testing
- SULT Allosteric Inhibition
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Albert Einstein College of Medicine
Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
Evaluation of the Effect of N-acetylcysteine in Preventing Cisplatin-Induced Toxicities in Cancer Patients
- Conditions
- Cisplatin Adverse Reaction, Cisplatin Nephrotoxicity, Cisplatin Induced Peripheral Neuropathy, Cancer Patients
- Trial name
- NCT06297369
- Testing
- N acetyl cysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Tonsillectomy, Adenotonsillectomy
Celecoxib for Pediatric Adenotonsillectomy
The investigators' study will involve the administration of either placebo or celecoxib to children aged 2 to 18 years of age undergoing tonsillectomy and assessing pain relief, impact on quality of life and side effect profile.
- Conditions
- Tonsillectomy, Adenotonsillectomy, Pain, Postoperative
- Trial name
- NCT00849966
- Testing
- Celebrex suspension
- Where
- Canada
- Volunteers
- 282 people
- Sponsor
- Children's Hospital of Eastern Ontario
Ciprofloxacin Adverse Reaction
Ciprofloxacin Utilization and Adverse Events Occurrence in Community Pharmacy Setting
Background: Ciprofloxacin is a fluoroquinolone that is commonly used to treat a variety of diseases. Ciprofloxacin resistance is rising, resulting in suboptimal patient care.
- Trial name
- NCT05916105
- Testing
- Ciprofloxacin Tablets
- Where
- Egypt
- Volunteers
- 151 people
- Sponsor
- Damanhour University
Weight Gain, Autism Spectrum Disorder
Pragmatic Trial Comparing Weight Gain in Children With Autism Taking Risperidone Versus Aripiprazole
This study aims to compare two FDA approved medications (aripiprazole and risperidone) for the treatment of behavioral dysregulation in children with autism spectrum disorders.
- Conditions
- Weight Gain, Autism Spectrum Disorder, Medication Side Effect
- Trial name
- NCT04903353
- Testing
- Comparison of Risperidone and Aripiprazole
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Injection Site, Injection Site Reaction
Sorrel 25R Injector - Sorrel Clinical Study Protocol
A prospective, open-label, single-center pilot study to evaluate the performance, safety and usability of the investigational SWI Device in healthy volunteers.
- Conditions
- Injection Site, Injection Site Reaction, Injection Site Irritation
- Trial name
- NCT05221333
- Testing
- Sorrel Wearable Injector
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Eitan Medical
Drug-Related Side Effects and Adverse Reactions
Impact of Clinical Pharmacist on Adverse Drug Events in Older Adults
Adverse drug events (ADE) are one of the major problems affecting quality of care and achievement of therapeutic goals in older adults (OA), increasing re-admissions, hospital stays, resource use, and problems on patient safety.
- Trial name
- NCT03156348
- Testing
- Clinical Pharmacist Care
- Where
- Chile
- Volunteers
- 611 people
- Sponsor
- University of Chile
Latent Tuberculosis Infection
Adverse Drug Reactions to Anti-TB Drugs in the Treatment of Latent Tuberculosis Infection
The investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-related toxicity in LTBI in Korean health…
- Trial name
- NCT03312647
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Hanyang University
Cisplatin Adverse Reaction
Evaluation of the Effect of Rosuvastatin on Cisplatin-induced Nephrotoxicity and Ototoxicity
Cisplatin is an effective anti-cancer drug for the treatment of many solid tumors in humans. Although the clinical response to cisplatin chemotherapy is encouraging, the nephrotoxicity and ototoxicity of the drug makes it…
- Trial name
- NCT04817904
- Testing
- Rosuvastatin 10mg
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Cairo University
Contraception
A Prospective Observational Study of the Clinical Performance of Femplant in Pakistan
This will be a non-comparative prospective observational study of women using Femplant as a primary method of contraception in Pakistan.
- Trial name
- NCT01463254
- Where
- Pakistan
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- FHI 360
HIV Infections, Gonorrhea
Cellulose Sulfate (CS) Gel and HIV in Nigeria
This is a Phase 3, multi-center, randomized, placebo-controlled trial to determine the effectiveness and safety of the 6% cellulose sulfate (CS) vaginal gel for the prevention of HIV infection.
- Conditions
- HIV Infections, Gonorrhea, Chlamydia Infections
- Trial name
- NCT00120770
- Testing
- Cellulose Sulfate Vaginal Gel (Microbicide)
- Where
- 2 sites in Nigeria
- Volunteers
- 2,160 people, healthy volunteers welcome
- Sponsor
- FHI 360