Clinical trials: Adverse Drug Reaction
Drug Hypersensitivity
Drug Provocation Test (DPT) to Paracetamol
Background : Paracetamol (acetaminophen) drug hypersensitivity reactions (DHR) are oonfirmed in about 10% of alleged cases. The diagnosis is made via an empirical drug provocation test (DPT).
- Trial name
- Paracetamol (NCT03771118)
- Where
- France
- Volunteers
- 498 people
- Sponsor
- University Hospital, Montpellier
Adverse Drug Events, Adverse Drug Reactions
The Effect of Medication Review in High-risk Emergency Department Patients
Adverse drug events are unintended and harmful events related to medication use and a leading cause of emergency department visits, unplanned hospital admissions and deaths.
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Medication-related Problems
- Trial name
- NCT02122965
- Testing
- Pharmacist-led medication review
- Where
- 3 sites in Canada
- Volunteers
- 10,805 people
- Sponsor
- University of British Columbia
Immunogenicity and Adverse Drug Effect of Vaccines Influenza, Chronic Kidney Disease
The Effect and Safety of the Seasonal Trivalent Influenza Vaccine in Chronic Kidney Disease Patients Not on Dialysis
In recent years, several studies revealed that the current influenza vaccine strategy might be of minimal vaccine effectiveness and had a smaller effect on reducing morbidity and mortality in the end-stage renal disease…
- Trial name
- NCT02105519
- Testing
- Seasonal influenza vaccine (AdimFlu-S)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Cheng-Kung University Hospital
Adverse Drug Reaction
A Prospective Trial to Assess Cost and Clinical Outcomes of a Clinical Pharmacogenomic Program
The INGenious trial will prospectively enroll a total of 6,000 patients, with 2,000 patients assigned to a pharmacogenetic testing arm and 4,000 to a control arm who will be followed, but not tested.
- Trial name
- INGenious (NCT02297126)
- Testing
- Pharmacogenetic Intervention Arm (pharmacogenetic testing)
- Where
- United States
- Volunteers
- 4,465 people
- Sponsor
- Indiana University
Hand-foot Syndrome, Hand-foot Skin Reaction
Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin Reaction
Hand-foot syndrome (HFS) is a side effect of chemotherapy. HFS is characterized by redness, swelling, and pain on the palms of the hands and/or soles of the feet, which can progress to blistering.
- Trial name
- DermLight (NCT04979078)
- Testing
- Photobiomodulation therapy (PBMT)
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Jessa Hospital
Adverse Drug Events
Impact of Medication Reconciliation Intervention on the Rate of Preventable Adverse Drug Events (ADEs) and Healthcare Utilization
The implementation of a medication reconciliation intervention including: medication reconciliation on admission and discharge, bedside medication counselling and take-home medication list, on the development of adverse drug…
- Trial name
- NCT02805270
- Testing
- medication reconciliation intervention
- Volunteers
- 587 people
- Sponsor
- Sultan Qaboos University
Medication Adherence, Medication Reaction
Taste of Medicines in Children
Some but not all children will refuse to take medicine because of its taste, which can lead to substantial worsening of disease, antibiotic resistance, increased health care costs, and even death.
- Trial name
- NCT04220918
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Children's Hospital of Philadelphia
Drug Reaction to Analgesic Nos
Topical Anesthetic for Procedures Through the Nose
To determine if RX0041-002 is a safe and effective topical anesthetic.
- Trial name
- NCT02667054
- Testing
- RX0041 4%, RX0041 8%
- Where
- 2 sites in United States
- Volunteers
- 648 people
- Sponsor
- Pharmaceutical Project Solutions, Inc.
Polypharmacy, General Surgery
Polypharmacy and Associated Risk Factors and Clinical Outcomes for Surgical Patients Discharged From Hospital
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT04805151
- Testing
- No intervention
- Where
- Iceland
- Volunteers
- 56,000 people
- Sponsor
- University of Iceland
Adverse Drug Event, Potential Adverse Drug Event, and Quality Measures
Emergency Pharmacist Safety Study
The Emergency Department (ED) is a unique environment in medicine, and many safety mechanisms used in other hospital settings cannot be applied in the ED.
- Trial name
- NCT00382434
- Testing
- presence of an emergency pharmacist in the ED
- Where
- United States
- Volunteers
- 10,224 people
- Sponsor
- University of Rochester
Covid19, Ivermectin Poisoning
Adverse Effects of Ivermectin Used in Egypt During COVID-19
retrograde study of common and rare adverse effects of multiple doses of ivermectin used during the coivd 19 pandemic in egypt
- Conditions
- Covid19, Ivermectin Poisoning, Drug Toxicity, Drug Side Effect
- Trial name
- NCT04747678
- Testing
- Ivermectin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Menoufia University
Latent Tuberculosis Infection
Risk of SDRs Under 3HP and 1HP Regimen for LTBI
Successful implement of preventive therapy for subjects with latent tuberculosis infection (LTBI) is the critical step for elimination of tuberculosis (TB).
- Trial name
- NCT04094012
- Testing
- isoniazid and rifapentine
- Where
- Taiwan
- Volunteers
- 490 people
- Sponsor
- National Taiwan University Hospital
Adverse Drug Reaction
Prevention of Adverse Drug Events (ADEs) in Hospitalised Older Patients
The next four decades will see a marked expansion of the elderly population in Ireland, in particular people aged over 80 yrs. Persons aged over 80 are the highest consumers of prescription medicines in Ireland and have the…
- Trial name
- NCT01467050
- Testing
- Application of STOPP/START criteria, Normal pharmaceutical care
- Where
- Ireland
- Volunteers
- 732 people
- Sponsor
- University College Cork
Adverse Drug Reactions
The Influence of CYP2C19 Polymorphisms on the Safety and Efficacy of Voriconazole
Voriconazole is a drug used to treat invasive fungal infections. The amount of voriconazole in a person's blood helps to determine how effectively it treats an infection, and how safe it is.
- Trial name
- NCT04547335
- Testing
- Voriconazole
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Dokuz Eylul University
Adverse Drug Reaction, Anxiety Disorders and Symptoms
Antidepressant Monotherapy on Depressive and Anxiety Symptom in Chinese Patients
The primary objective is to evaluate the improvement of antidepressant monotherapy on depressive and anxiety symptom in Chinese patients who meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)…
- Trial name
- NCT02012504
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Injection Site Reaction, Injection Site Bruising
Effectiveness of Mechano-Analgesia and Cold Application on Ecchymosis, Pain and Satisfaction at Subcutaneous Heparin Injection
Fifty-five patients received three subcutaneous heparin injections (165 injections) by the same investigator using additional techniques such as mechano-analgesia and cold application, and without any additional techniques.
- Trial name
- NCT03645369
- Testing
- ShotBlocker, Ice pack
- Volunteers
- 165 people
- Sponsor
- Istanbul Saglik Bilimleri University
Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced
Granulocyte Colony Stimulating Factor for for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer
This study aims to analyze the effects of long-acting versus short-acting granulocyte colony stimulating factor (G-CSF) on the prevention febrile neutropenia (FN) in epithelial ovarian cancer patients.
- Conditions
- Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced, Epithelial Ovarian Cancer, Colony Stimulating Factors Adverse Reaction
- Trial name
- NCT04101760
- Testing
- Long-acting granulocyte colony stimulating factor, Short-acting granulocyte colony stimulating factor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Lei Li
Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
Peppermint Oil for the Treatment of Irritable Bowel Syndrome or Functional Abdominal Pain in Children: the MINT Study
Peppermint oil has shown to be effective in the treatment of Irritable Bowel Syndrome (IBS) symptoms in adults. Few studies of low quality are performed in an paediatric setting.
- Conditions
- Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Child, Adolescent
- Trial name
- MINT (NCT05799053)
- Testing
- Small intestinal release peppermint oil, Peppermint sweets
- Where
- 3 sites in Netherlands
- Volunteers
- 228 people
- Sponsor
- St. Antonius Hospital
Medication Adherence, Medication Nonadherence
Feasibility of Using a Telemedicine Medication Delivery Unit for Older Adults
Care transition interventions have been successful in reducing medication-related problems and associated rehospitalization primarily by focusing on medication reconciliation conducted by trained healthcare professionals.
- Conditions
- Medication Adherence, Medication Nonadherence, Adverse Reaction to Drug
- Trial name
- EMMA (NCT01430702)
- Testing
- Computerized medication delivery unit (Electronic Medication Management Assistant (EMMA)
- Where
- United States
- Sponsor
- University of Pittsburgh
Multiple Sclerosis, Relapsing-Remitting
A Post-Authorization Safety Study of Interferon Beta Therapy in Participants With Multiple Sclerosis
The purpose of this study is to investigate the safety of subcutaneous (SC) interferon beta therapies with regard to frequency of injection site reactions (ISR) and flu-like symptoms (FLS) as reported by the relapsing-remitting…
- Trial name
- PERFECT (NCT03347370)
- Testing
- SC Peginterferon beta-1a, SC interferon beta-1a, SC interferon beta-1b
- Where
- Germany
- Volunteers
- 626 people
- Sponsor
- Biogen