Clinical trials: Adverse Drug Related Events
Cancer, Drug Toxicity
Atrial Fibrillation in Active Cancer Patients
Atrial fibrillation is a common complication of both cancer and anticancer drugs but the consequences of such events remain poorly known and are not adressed in both phase III oncological trials and cardiological guidelines.
- Conditions
- Cancer, Drug Toxicity, Atrial Fibrillation, Cardiovascular Complication
- Trial name
- AFIB-CANCER (NCT04696081)
- Testing
- occurence of atrial fibrillation
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Caen
Length of Stay, Complications
Study Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer
A new notion"Fast Track Multi-Discipline Treatment" for colorectal cancer is thought with several benefits such as shorter hospitalization stay and less costs.
- Conditions
- Length of Stay, Complications, Adverse Drug Event, Quality of Life
- Trial name
- NCT01080547
- Testing
- Laparoscopic Surgery for Colorectal Cancer, XELOX Chemotherapy, mFolfox6 chemotherapy
- Where
- 2 sites in China
- Volunteers
- 374 people
- Sponsor
- Zhejiang University
Myeloma, Heart Failure
Cardiovascular Complications of Carfilzomib
Cardiovascular toxicity of carfilzomib, a last generation proteasome inhibitor, is highly incident according to retrospective data. Prospective cohort study of patients initiated on carfilzomib.
- Conditions
- Myeloma, Heart Failure, Hypertension
- Trial name
- ICARE (NCT04407858)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- European Georges Pompidou Hospital
Adverse Drug Event
NOCDURNA PASS Study Using Registries in Denmark, Germany and Sweden
A study using medical records to evaluate safety issues for the NOCDURNA drug using national register data from Denmark and Sweden, and a health care register covering parts of Germany.
- Trial name
- NCT04740645
- Testing
- NOCDURNA Cohort, LUTS Cohort
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 1,099,551 people
- Sponsor
- Ferring Pharmaceuticals
Adverse Drug Event
Adverse Reactions Following COVID-19 Vaccination Among Ecuadorian Healthcare Workers
Limited large-scale studies have been conducted to investigate the adverse effects of COVID-19 vaccine in Latin America, particularly among the healthcare worker (HCW) population in Ecuador.
- Trial name
- NCT05113472
- Testing
- Pfizer-BioNTech COVID-19 vaccine
- Where
- Ecuador
- Volunteers
- 1,291 people, healthy volunteers welcome
- Sponsor
- Respiralab
Acute Lymphoblastic Leukemia, Pediatric, Adverse Drug Event
Pharmacogenomic Analysis in Pediatric Acute Lymphoblastic Leukemia
This is a retrospective biobank study evaluating the impact of novel genetic variants in a population of 6-mercaptopurine treated pediatric acute lymphoblastic leukemia patients.
- Trial name
- NCT04770922
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cipherome, Inc.
Aging, Benzodiazepine Sedative Adverse Reaction
Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults
Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable…
- Conditions
- Aging, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction, Adverse Drug Event
- Trial name
- NUDGE-EHR (NCT04284553)
- Testing
- Order Entry, Open Encounter, Follow-up booster Alert
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Brigham and Women's Hospital
Neoplasms, Immunotherapy
IMMUNO-FIT Observational Study
This observational study will investigate how immunotherapy affects physical fitness, quality of life, and treatment tolerance in adults with solid cancers.
- Conditions
- Neoplasms, Immunotherapy, Physical Fitness, Quality of Life
- Trial name
- NCT07354971
- Testing
- Observational Study - No Study Intervention
- Where
- United Kingdom
- Volunteers
- 67 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Medication Safety
Pharmacist and Data Driven Quality Improvement in Primary Care
P-DQIP is an intervention to improve prescribing safety in primary care. The 'intervention' is a health board quality improvement programme that will be implemented across all practices in one National Health Service (NHS) board…
- Trial name
- P-DQIP (NCT03747107)
- Testing
- P-DQIP
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Dundee
Adverse Drug Event
Impact of an Optimized Communication on the Readmission for Adverse Drug Event
Emergency departments (EDs) are a crucial element of health care systems as they constitute the interface between hospital and communities.
- Trial name
- URGEIM (NCT03725046)
- Testing
- Optimized information transmission
- Where
- France
- Volunteers
- 346 people
- Sponsor
- University Hospital, Montpellier
HIV Infections, Clinical Outcomes
Dolutegravir and Clinical Outcomes Among ART-recipients in Brazil
Access to antiretroviral therapy (ART) in low-income and middle-income countries has been scaled-up effectively over recent years.
- Conditions
- HIV Infections, Clinical Outcomes, Adverse Drug Event, Effect of Drugs
- Trial name
- CODE (NCT04326504)
- Testing
- No intervention
- Where
- 3 sites in Brazil
- Volunteers
- 5,000 people
- Sponsor
- Fundação Bahiana de Infectologia
Neutropenia, TNF-alpha Inhibitors
Neutropenia With TNF-α Inhibitors
Tumor necrosis factor-alpha (TNF-α) inhibitors, including infliximab, etanercept, adalimumab, certolizumab, and golimumab, have become cornerstone therapies in the management of rheumatologic disorders.
- Trial name
- NCT07237906
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Burak Ugur Cetin
Neonatal Intensive Care Unit, Medication Errors
Drug-Related Problems in Neonatal Patients
Drug-related problems in newborn babies have been reported with a rate of 4-30%. It is estimated that the higher rates of these problems in hospitalized children under the age of two are related to the variety of drugs used and…
- Conditions
- Neonatal Intensive Care Unit, Medication Errors, Drug-Related Problems, Adverse Drug Event
- Trial name
- NCT04899960
- Testing
- Clinical Pharmacist Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 512 people
- Sponsor
- Hacettepe University
Adverse Drug Event, Potential Adverse Drug Event, and Quality Measures
Emergency Pharmacist Safety Study
The Emergency Department (ED) is a unique environment in medicine, and many safety mechanisms used in other hospital settings cannot be applied in the ED.
- Trial name
- NCT00382434
- Testing
- presence of an emergency pharmacist in the ED
- Where
- United States
- Volunteers
- 10,224 people
- Sponsor
- University of Rochester
Stage III Melanoma
Interferon Toxicities in Melanoma Treatment
The primary objective of this study is to quantify and compare the prevalence of adverse events (AEs) in patients with stage III melanoma before and after initiation of interferon (IFN) therapy in a real-world setting.
- Trial name
- ITMT (NCT02794636)
- Volunteers
- 436 people
- Sponsor
- Bristol-Myers Squibb
Adverse Drug Events
Pharmacists and Pharmacy Technicians to Improve Admission Medication History Accuracy
We tested two interventions to improve the accuracy of medication histories obtained at hospital admission. The interventions target elderly and chronically ill patients prone to erroneous medication histories and resultant…
- Trial name
- NCT02026453
- Testing
- Pharmacist obtains admission medication history, Pharmacy technician obtains admission medication history
- Volunteers
- 306 people
- Sponsor
- Cedars-Sinai Medical Center
Adverse Drug Event, Colon Cancer
Implementation and Quality Assurance of DPYD-genotyping in Patients Treated With Fluoropyrimidines.
The purpose of this study is to examine the benefits of a clinical implementation of a DPYD-genotype test to patients starting treatment with fluoropyrimidines (Fluorouracil (5-FU), capecitabine, tegafur).
- Conditions
- Adverse Drug Event, Colon Cancer, Breast Cancer, Pancreas Cancer
- Trial name
- NCT05266300
- Testing
- DPYD genotype
- Where
- Denmark
- Volunteers
- 722 people
- Sponsor
- University of Southern Denmark
Grade 2 Hand-foot Syndrom
Efficacy of the Cosmetic Product "Onco-Repair" on Grade 2 Hand Foot Syndrome
The aim of the study is to assess the restorative efficacy of the cosmetic product "Onco-Repair" vs placebo of the most affected palmer face in subject with grade 2 HFS induced by targeted therapies or conventional chemotherapy.
- Trial name
- OCRP (NCT03612011)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Quanta Medical
Pain
Diclofenac 25mg/Paracetamol 500 mg and Diclofenac 50 mg/Paracetamol 500 mg for Patients With Pain
The purpose of this study is to collect adverse events and identify risk factors in patients that are taking Dolocordralan Extra 25® and Dolocordralan Extra Forte®
- Trial name
- NCT02651363
- Where
- Peru
- Volunteers
- 374 people
- Sponsor
- Bristol-Myers Squibb
Adverse Drug Event
Evaluation of the Implementation of the Pharmacogenetics and Personalized Medicine Program "MedeA" in the Extremadura Health Service.
An open longitudinal observational study, non-randomized, which will include the adult population, attended by the SES, in which preference will be given to those patients under treatment with drugs that can produce relevant…
- Trial name
- MedeA (NCT06607445)
- Where
- Spain
- Volunteers
- 6,445 people, healthy volunteers welcome
- Sponsor
- Complejo Hospitalario Universitario de Badajoz