Clinical trials: Adverse Effect, open to volunteers
Head and Neck Cancer, Pelvic Cancer
Health Oriented Protocol for Epidermal Radiodermatitis
Radiation therapy is a standard treatment for malignant tumors of the head and neck and pelvic regions, used alone or in combination with chemotherapy.
- Conditions
- Head and Neck Cancer, Pelvic Cancer, Radiation Skin Injury, Gynecologic Cancer
- Trial name
- HOPE (NCT07129525)
- Testing
- Radiation therapy
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Doxorubicin Induced Cardiotoxicity, Doxorubicin Induced Cardiomyopathy
The Impact of Using Nicorandil for the Prevention of Doxorubicin-Induced Cardiotoxicity
Breast cancer is one of the world's most common cancers in females. Most of the chemotherapy protocols used to treat breast cancer involve doxorubicin. Doxorubicin has a very significant antitumor effect on breast tumors.
- Conditions
- Doxorubicin Induced Cardiotoxicity, Doxorubicin Induced Cardiomyopathy, Doxorubicin, Doxorubicin Adverse Reaction
- Trial name
- NICBREASTRCT (NCT07897409)
- Testing
- Nicorandil Oral Tablet, Adriamycin (Doxorubicin)
- Where
- Egypt
- Volunteers
- 146 people
- Sponsor
- Universiti Sains Malaysia
Adverse Drug Reaction (ADR), Polypharmacy Patients
IPGx PILOT Whole Genome Sequencing Extension Cohort
The investigator's primary aim is to evaluate polypharmacy-associated adverse drug reactions (ADR) in a pilot study of at-risk patients using state-of-the-art pharmacogenomic technology and to use this information to make…
- Trial name
- NCT06766071
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Texas A&M University
Antipsychotic-induced Weight Gain (AIWG), Antipsychotic-induced Weight Gain
Dapagliflozin Versus Metformin for the Management of Antipsychotic-Induced Weight Gain: A Pragmatic Pilot Randomized Controlled Trial
The goal of this clinical trial is to learn whether dapagliflozin can help manage weight gain caused by antipsychotic medications in people aged 16 years or older who are receiving antipsychotic treatment and have developed…
- Trial name
- NCT07342764
- Testing
- Dapagliflozin, Metformin, Common Lifestyle Program
- Where
- Oman
- Volunteers
- 110 people
- Sponsor
- Sultan Qaboos University
Oropharynx Cancer, Radiotherapy; Complications
Adaptive RadioTherapy for OroPharynx Cancer
This is a phase II randomized trial, where patients with histologically proven squamous cell carcinoma of oropharynx that have primary tumor (T3 - T4) in place, treated with curative intent chemoradiation, will be randomized to…
- Conditions
- Oropharynx Cancer, Radiotherapy; Complications, Radiotherapy Side Effect, Dysphagia
- Trial name
- ART-OPC (NCT04901234)
- Testing
- Standard radiotherapy +/- chemotherapy, Experimental radiotherapy +/- chemotherapy
- Where
- 2 sites in Australia, Canada
- Volunteers
- 120 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
ADHD, Sleep Disturbance
A Study to Evaluate the Effects of a Supplement on the Side Effects Associated With Stimulant Medications
This is a hybrid, two-arm, triple-blind, placebo-controlled, randomized clinical trial evaluating the efficacy of the Stasis supplement on reducing oxidative stress, cortisol levels, and side effects associated with stimulant…
- Conditions
- ADHD, Sleep Disturbance, Brain Fog
- Trial name
- NCT07380412
- Testing
- Stasis Daytime and Nighttime
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Outliers, Inc.
Pectus Excavatum, Chest Deformities
SPSIPB Versus SAPB for Postoperative Analgesia After Minimally Invasive Repair of Pectus Excavatum
This prospective observational cohort study will compare postoperative analgesic outcomes in patients undergoing minimally invasive repair of pectus excavatum.
- Trial name
- NCT07697222
- Testing
- Postoperative Analgesia Protocol, Bispectral Index Monitoring, Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Marmara University
Breast Cancer, Metastatic Breast Cancer
Impact of Genetic Variants on the Toxicity of Antibody-Drug Conjugates in Locally Advanced or Metastatic Breast Cancer: The Role of the UGT1A1 Gene as a Predictive Biomarker of Therapeutic Response
The metabolism of anticancer drugs is influenced by genetic variants that affect their bioavailability and toxicity. In the case of antibody-drug conjugates (ADCs), such as sacituzumab-govitecan (SG), trastuzumab-deruxtecan…
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Drug-Related Side Effects and Adverse Reactions, Pharmacogenetic Variant
- Trial name
- NCT07582887
- Testing
- Sacituzumab Govitecan, Trastuzumab deruxtecan, Datopotamab Deruxtecan
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
Cancer, Oncology
Longitudinal Registry Including Patients Treated With Heavy Particles
The purpose of this registry is to collect retrospective and prospective standardized data of patients treated with particle therapy, either with protons or carbon ions, at the National Center for Oncological Hadrontherapy (CNAO)…
- Conditions
- Cancer, Oncology, Radiation Exposure, Radiotherapy Side Effect
- Trial name
- NCT05203250
- Testing
- Heavy-ion therapy (hadrontherapy)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Uterine Septum, Surgical Complication
Surgical Approach to Uterine Septum
The objective of this study is to determine if the use of scissors without electrosurgery is superior to bipolar electrosurgery for resection of uterine septum.
- Conditions
- Uterine Septum, Surgical Complication, Septum; Uterus, Treatment Side Effects
- Trial name
- NCT06315582
- Testing
- Removal of uterine septum with hysteroscopic scissors without electrosurgery., Hysteroscopic septoplasty utilizing bipolar electrosurgery
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Adverse Drug Reaction (ADR)
National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children
The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to…
- Trial name
- NCT00414115
- Where
- Canada
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Kidney Failure, Acute, Myopathy; Drugs
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
The study aims to improve the safety of the electroporation ablation (PFA) procedure by using muscle relaxants to reduce skeletal muscle damage during the procedure.
- Conditions
- Kidney Failure, Acute, Myopathy; Drugs, Heart Arrhythmia, Succinylcholine Sensitivity
- Trial name
- NCT06707532
- Testing
- Propofol, Rocuronium
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Melanoma
Feasibility of an Enhanced Symptom Monitoring and Expedited Subspecialty Care Referral Intervention to Improve Side Effect Management for Patients With Melanoma Receiving an Immune Checkpoint Inhibitor
This clinical trial tests the feasibility of patient reported outcomes monitoring with early, rapid immunotherapy toxicity subspecialty care to improve side effect management for patients with melanoma receiving an immune…
- Trial name
- NCT07660666
- Testing
- Electronic Health Record Review, Internet-Based Intervention, Patient Navigation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer
Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients
The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium…
- Trial name
- NCT02772367
- Testing
- skin punch biopsy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphoma, Cancer
Feasibility of Intermittent Fasting During Chemotherapy
The goal of this randomized controlled parallel group trial is to examine if fasting before and after chemotherapy is safe, feasible and acceptable.
- Conditions
- Lymphoma, Cancer, Fasting
- Trial name
- FasteStudien (NCT06645093)
- Testing
- Fasting
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Oslo
Transfusion Reaction, Transfusion Related Complication
Transfusion Surveillance in Anaesthesia
the aim of this register is to collect exhaustively the different data available surrounding a transfusion act in the context of an active haemorrhage.
- Conditions
- Transfusion Reaction, Transfusion Related Complication, Anesthesia, Anesthesia; Shock
- Trial name
- STAR (NCT06403163)
- Testing
- Transfusion
- Where
- Belgium
- Volunteers
- 50,000 people
- Sponsor
- Erasme University Hospital
Levonorgestrel Adverse Reaction, Temporomandibular Joint Disorders
Temporomandibular Disorder in Use of Levonorgestrel Intrauterine System
The goal of this clinical trial is to investigate the possible role of levonorgestrel intrauterine system use(LIU) in the pathogenesis of temporomandibular joint disorder (TMD).
- Conditions
- Levonorgestrel Adverse Reaction, Temporomandibular Joint Disorders, Temporomandibular Disorder
- Trial name
- NCT06500390
- Testing
- Examination of temporomandibular joint and masticator muscles
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Marmara University
Adverse Childhood Experiences, Developmental Risk
Growing Up in Multifactorial Risk Conditions
The perinatal period brings significant physiological and emotional changes in mothers, linked to pregnancy, childbirth, and caring for a newborn.
- Conditions
- Adverse Childhood Experiences, Developmental Risk, Psychomotor Development Disorders, Neurodevelopmental Disorders
- Trial name
- CORE (NCT07477899)
- Testing
- Home visiting programme
- Where
- Italy
- Volunteers
- 352 people
- Sponsor
- IRCCS Eugenio Medea
Tonsillectomy With or Without Adenoidectomy
Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy
To observe the effects of remimazolam versus ciprofol TIVA on PRAE in pediatric tonsillectomy and adenoidectomy.
- Trial name
- NCT07118579
- Testing
- Remimazolam, Propofol, Ciprofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tongji Hospital
Elevated Lp(a), Atherosclerotic Cardiovascular Disease (ASCVD)
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.
- Trial name
- MOVE-Lp(a) (NCT07157774)
- Testing
- Muvalaplin
- Where
- 804 sites in United States, Argentina and 26 more
- Volunteers
- 10,450 people
- Sponsor
- Eli Lilly and Company