Clinical trials: Adverse Effects, open to volunteers
Anesthesia; Adverse Effect, Spinal and Epidural
Paramedian Incidence Angles in Spinal Anaesthesia
The objective here is to quantify the number of punctures and redirections during routine practice in the anesthesiology department, verify the final angle of incidence and the sac-skin distance by ultrasound, and determine the…
- Trial name
- NCT07210892
- Testing
- Measurement of needle insertion angles
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de Terrassa
Noise Exposure, Noise-induced Hearing Loss
Non-Invasive System to Deliver Therapeutic Hypothermia for Protection Against Noise-Induced Hearing Loss
The goal of this interventional clinical study is to investigate the use of mild therapeutic hypothermia devices for preservation of sensory structures in the cochlea after noise exposure. The main aims of the study are: 1.
- Conditions
- Noise Exposure, Noise-induced Hearing Loss, Noise; Adverse Effect, Mild Therapeutic Hypothermia
- Trial name
- NCT06729632
- Testing
- Cold pack-delivered mild therapeutic hypothermia
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Restorear Devices LLC
Adverse Drug Reaction (ADR)
National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children
The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to…
- Trial name
- NCT00414115
- Where
- Canada
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Volunteers, Vibration; Adverse Effect
Acute Effects of Smartphone-Delivered Local Vibration on Hand Sensorimotor Performance
This study investigates the acute effects of smartphone-delivered local vibration on hand sensorimotor performance in healthy young adults.
- Trial name
- SmartVib (NCT07521228)
- Testing
- Smartphone Local Vibration at 80 Hz, Smartphone Local Vibration at 150 Hz, Smartphone Local Vibration at 220 Hz
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Psychiatric Disorder, Cognition Disorder
MEOP - Multidimensional Evaluations in Oncological Psychiatry
Cancer is among the leading causes of morbidity and mortality worldwide, profoundly affecting patients' lives at every level, and its psychological and psychiatric impacts remain a major concern.
- Conditions
- Psychiatric Disorder, Cognition Disorder, Treatment Compliance, Adverse Drug Event
- Trial name
- MEOP (NCT07406113)
- Testing
- Psychiatric and neuropsychological evaluation through rating scales
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Adverse Effect, Feasibility Study
Feasibility and Safety of Sciatic Nerve Paraneural Sheath Block Using a Mid-Femoral Lateral Approach
This study is designed as a randomized controlled trial aiming to evaluate the feasibility and safety of ultrasound-guided mid-femoral lateral approach sciatic nerve paraneural sheath block, in order to provide a new sciatic…
- Conditions
- Adverse Effect, Feasibility Study, Safety and Effectiveness
- Trial name
- iSNB-LF (NCT07366853)
- Testing
- Ultrasound-guided lateral mid-femoral sciatic nerve block, Ultrasound-guided popliteal sciatic nerve block
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Behavior Change Interventions, Work Environment Adverse Effects
From Yearly Checks to Daily Progress: Evaluating Goal Attainment Scaling (GAS) in Systematic Work Environment Management (SAM) Within the Municipal Sector
The goal of this project is to evaluate a practical method for improving systematic work environment management (SAM) by focusing on health-promoting factors rather than identifying risk-factors, and deficiencies.
- Conditions
- Behavior Change Interventions, Work Environment Adverse Effects, Health Factors, Goal Attainment Scaling
- Trial name
- GAS for SAM (NCT06893471)
- Testing
- GAS for SAM
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Adverse Effects, Healthy
Effect of Probiotic Intake in Healthy Population
The main objective of this project is to evaluate the absence of adverse gastrointestinal effects following the consumption of a daily probiotic capsule during 15 days.
- Trial name
- PROBIO (NCT07165457)
- Testing
- Probiotic group
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Adverse Drug Reaction, Therapy Failure
Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure
Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care.
- Trial name
- NCT04154553
- Testing
- Buccal swab, EDTA Blood sample (4.9mL), Serum sample (7.5mL)
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Continuous Positive Airway Pressure, Adverse Effect
Addressing Unintentional Leakage When Using Nasal CPAP - Study A
Oral unintentional leak is a common side effect of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) treatment.
- Conditions
- Continuous Positive Airway Pressure, Adverse Effect, Obstructive Sleep Apnea
- Trial name
- NCT06570616
- Testing
- CPAP (fixed mode), APAP (automatic mode)
- Where
- 2 sites in Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Continuous Positive Airway Pressure, Adverse Effect
Addressing Unintentional Leakage When Using Nasal CPAP - Study B
Oral unintentional leak is a common side effect of continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA) treatment.
- Conditions
- Continuous Positive Airway Pressure, Adverse Effect, Obstructive Sleep Apnea
- Trial name
- NCT06570629
- Testing
- Oronasal CPAP, Nasal CPAP plus Chinstrap
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Benzodiazepine Adverse Reaction, Depression, Anxiety
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers.
- Conditions
- Benzodiazepine Adverse Reaction, Depression, Anxiety, Benzodiazepine Dependence
- Trial name
- NCT06250842
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
T-Cell Dysfunction, Chemotherapy Effect
Studying the Senescent T Cell Features and Its Relationship with the Chemotherapy Efficacy in Young TNBC
The goal of this observational study is to learn about the features of senescent T lymphocytes induced by chemotherapy and its relationship with the efficacy of neoadjuvant chemotherapy in young triple-negative breast cancer…
- Conditions
- T-Cell Dysfunction, Chemotherapy Effect, Adverse Events
- Trial name
- STFREiYTNBC (NCT06684054)
- Testing
- docetaxel, anthracycline, cyclophosphamide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Noise; Adverse Effect, Noise Exposure
Noise, Oxidative Stress and Cardiovascular System
Environmental noise represents a health problem for at least one in five citizens of the European Union. Noise exposure leads to the development of arterial hypertension, myocardial infarction, stroke, and obesity.
- Trial name
- NOXYCARD (NCT06294340)
- Testing
- Exposure to loud pre-recorded road traffic noise
- Where
- Serbia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Perioperative Complication, Perioperative/Postoperative Complications
Registry of Anesthesia and Perioperative Medicine
To assess mortality and morbidity associated to anesthesia interventions
- Conditions
- Perioperative Complication, Perioperative/Postoperative Complications, Anesthesia Morbidity, Anesthesia; Adverse Effect
- Trial name
- RAMP (NCT05869578)
- Testing
- Anesthesia Intervention
- Where
- Chile
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Alemana de Santiago
Esophageal Neoplasms, Adverse Drug Event
Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer
This study is a randomized, open, parallel controlled clinical trial. The main purpose of this study was to compare the changes in body weight/body mass index (BMI) before and after treatment between the two groups of patients…
- Trial name
- NCT05800054
- Testing
- Nutritional Support Team, Docetaxel, cisplatin
- Where
- China
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Prostate Cancer, Adverse Effects Surgery
TRANBERG® Transperineal MR/US Fusion Laser--Induced Thermal Therapy for Men With Prostate Cancer
This study is set up as a phase I prospective, single center, device interventional pilot study carried in office setting under local anesthesia.
- Conditions
- Prostate Cancer, Adverse Effects Surgery, MRI, Ultrasound
- Trial name
- TPF-LITT (NCT05698576)
- Testing
- TRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Urological Research Network, LLC