Clinical trials: Adverse Pregnancy Outcomes
Chronic Kidney Disease
Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
The purpose of the present study is to investigate the association between the accumulation of advanced glycation end-products (AGE) and adverse outcomes (e.g.
- Trial name
- AGED (NCT02878317)
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Nottingham
Sexually Transmitted Infection, HIV/AIDS
Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes (Philani Ndiphile)
This study aims to evaluate different screening strategies to decrease the burden of Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT) and Trichomonas vaginalis (TV) among pregnant women, and reduce adverse birth outcomes.
- Conditions
- Sexually Transmitted Infection, HIV/AIDS, Cost-effectiveness, Birth Outcomes
- Trial name
- NCT04446611
- Testing
- First antenatal care + test-of-cure, First antenatal care + week 30-34 gestation (no test-of-cure)
- Where
- South Africa
- Volunteers
- 2,247 people, healthy volunteers welcome
- Sponsor
- Foundation for Professional Development (Pty) Ltd
Miscarriage, Stillbirth
Follow-up of Pregnant Women After a Mass Vaccination of Oral Cholera Vaccine (ShancholTM) in Nsanje Malawi
This study, to be carried out immediately following an emergency, reactive cholera vaccination campaign in Nsanje District, Malawi, will be a cohort study to estimate the safety of killed oral cholera vaccine (OCV), in pregnant…
- Conditions
- Miscarriage, Stillbirth, Cholera
- Trial name
- NCT02499172
- Testing
- Shanchol
- Where
- United States
- Volunteers
- 2,758 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Birth Outcomes, Safety
Simultaneous mRNA COVID-19 and IIV Vaccination in Pregnancy Study
This study is a prospective, randomized clinical trial. During this study, pregnant women will be randomly assigned to receive IIV and mRNA COVID-19 vaccine either simultaneously or sequentially (7-14 days apart).
- Conditions
- Birth Outcomes, Safety, Adverse Event Following Immunization
- Trial name
- NCT06503900
- Testing
- mRNA COVID-19 vaccine, IIV4 (quadrivalent inactivated influenza vaccine)
- Where
- 6 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Duke University
Labor and Delivery
A Randomized Trial of Induction Versus Expectant Management
A randomized clinical trial to assess whether elective induction of labor at 39 weeks of gestation compared with expectant management will improve outcomes.
- Trial name
- ARRIVE (NCT01990612)
- Testing
- Elective Induction of Labor
- Where
- 16 sites in United States
- Volunteers
- 6,106 people
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia Postpartum, Adverse Pregnancy Outcomes
A Community Health Worker Intervention to Address Adverse Pregnancy Outcomes
United States maternal mortality and preterm birth rates are among the highest among high-income countries due in part to a combination of racial, regional and socioeconomic disparities in access to care and overall health.
- Trial name
- AW2H (NCT06353256)
- Testing
- usual postpartum care, usual postpartum care + community health worker intervention
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Bacterial Vaginosis
Rwanda Vaginal Microbiota Restoration Study
A pilot randomized controlled clinical trial of intermittent use of two different vaginal lactobacilli-containing probiotics, and oral metronidazole, to prevent bacterial vaginosis recurrence.
- Trial name
- VMB (NCT02459665)
- Testing
- Vaginal multiple lactobacilli-containing probiotic for prevention of BV recurrence, Prophylactic use of metronidazole pills (500 mg), Vaginal Lcr35-containing probiotic for prevention of BV recurrence
- Volunteers
- 68 people
- Sponsor
- Janneke van de Wijgert
Pre-Eclampsia, Pre-Term
Vascular Inflammation and Anti-inflammatory Supplements After Adverse Pregnancy Outcomes
Women who had an adverse pregnancy outcome (APO), such as preeclampsia, preterm birth, or gestational diabetes, have a higher risk for heart disease.
- Conditions
- Pre-Eclampsia, Pre-Term, Intrauterine Growth Restriction, Hypertension in Pregnancy
- Trial name
- VIA (NCT04633551)
- Testing
- Anti-inflammatory supplement
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
HSV-2 Infection, PreTerm Birth
Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes
Preterm delivery (PTD), together with low birthweight (LBW), is the leading cause of infant death and illness, affecting 500,000 births with annual medical costs of more than $26 billion in the U.S. each year.
- Conditions
- HSV-2 Infection, PreTerm Birth, Pregnancy Complications
- Trial name
- PCORIHSV (NCT02986802)
- Where
- United States
- Volunteers
- 89,132 people
- Sponsor
- Kaiser Permanente
Chronic Kidney Disease
A Primary-Secondary Care Partnership to Prevent Adverse Outcomes in Chronic Kidney Disease
Chronic kidney disease (CKD) is a major public health problem with a UK prevalence of 8-10%. The study hypothesis is to ascertain if intensive primary care led disease management programmes for CKD, supported by input from…
- Trial name
- NCT01688141
- Testing
- Enhanced management
- Where
- 3 sites in United Kingdom
- Volunteers
- 28,304 people
- Sponsor
- University Hospitals, Leicester
Chlamydia Trachomatis Infection
Genital CT Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Pilot RCT
This study aims to identify the relationship between genital C. trachomatis and adverse pregnancy outcomes, and investigate whether screening and treatment of genital C.
- Trial name
- RCT (NCT03862495)
- Testing
- C. trachomatis and N. gonorrhoeae, Azithromycin, Partner notification and treatment
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Safety, Adverse Event Following Immunisation
Safety of RIV4 Versus IIV4 in Pregnant Women
This is a prospective, randomized clinical trial. During the study, pregnant women will be randomized (1:1) to receive RIV4 or IIV4. Vaccines will be administered by licensed providers.
- Conditions
- Safety, Adverse Event Following Immunisation, Birth Outcomes
- Trial name
- NCT03969641
- Testing
- Quadrivalent Recombinant Influenza Vaccine, Quadrivalent Inactivated Influenza Vaccine
- Where
- 3 sites in United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Duke University