Clinical trials: Adverse Reaction
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Colorectal Cancer, Liver Metastases
SAMe in Prevention of Oxaliplatin-associated Liver Injury
This is an open-label, phase II study that may provide evidence that taking S-adenosylmethionine (SAMe) supplementation prevents oxaliplatin, a type of chemotherapy drug, associated liver toxicity in patients with resectable…
- Conditions
- Colorectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer, Liver Injury
- Trial name
- NCT06258525
- Testing
- Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Diffuse Large B-cell Lymphoma (DLBCL), Cardiotoxicity
The CARDIOPROTECT Trial
This trial is to evaluate if dexrazoxane is safer and more effective than liposomal doxorubicin in preventing heart failure events in participants with diffuse large B-cell lymphoma (DLBCL) undergoing either standard of care…
- Conditions
- Diffuse Large B-cell Lymphoma (DLBCL), Cardiotoxicity, Lymphoma
- Trial name
- NCT07654426
- Testing
- Dexrazoxane, Doxorubicin, Liposomal Doxorubicin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiac Toxicity
Race Difference Moxifloxacin-induced QT Prolongation Between Healthy Chinese and Caucasian Volunteers
A double-center, randomized, double-blinded, 2-way crossover, placebo-controlled Study: Comparison of single oral dose 400mg Moxifloxacin-induced QT prolongation between healthy Chinese volunteers and Caucasian Volunteers Study…
- Trial name
- NCT02119091
- Testing
- Moxifloxacin
- Where
- 2 sites in United States, China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Haiyan Li
Brain Ischemia, Adverse Effect of Thrombolytic Drugs
Pre-stroke Cognitive Status and Thrombolytic Therapy
At the acute stage of cerebral ischaemia, the only effective drug that increases the proportion of patients who survive without dependency is thrombolytic therapy by intravenous (i.v.) tissue-plasminogen activator (t-PA).
- Conditions
- Brain Ischemia, Adverse Effect of Thrombolytic Drugs, Impaired Cognition, Dementia
- Trial name
- OPHELIE-COG (NCT01713491)
- Where
- 9 sites in France, Japan
- Volunteers
- 205 people
- Sponsor
- University Hospital, Lille
Tuberculosis Infection
Analysis of Liver Injury Risk Factors in a Multiethnic Population Treated With Antituberculosis Drugs
Tuberculosis (TB) is the world's second leading cause of death from a single infectious agent after COVID-19. In 2022, TB was estimated to have affected 10.6 million people, of whom 1.3 million died because of it, despite the…
- Trial name
- TUBILI (NCT06539455)
- Testing
- standard anti-TB treatment
- Where
- Italy
- Volunteers
- 127 people
- Sponsor
- Stefania Cheli
Palmar-Plantar Erythrodysesthesia Syndrome
Safety and Efficacy Placebo Controlled Study of ATH008 Cream in PPES Patients Secondary to Capecitabine
The aim of this study is to evaluate the safety and efficacy of ATH008 cream in patients with Palmar-Plantar Erythrodysesthesia Syndrome (PPES) secondary to capecitabine therapy.
- Trial name
- NCT01316406
- Testing
- ATH008
- Where
- 26 sites in Belgium, Germany and 2 more
- Volunteers
- 122 people
- Sponsor
- Advancell - Advanced In Vitro Cell Technologies, S.A.
Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction
Combination of Nitrous Oxide 70% With Fentanyl Intranasal for Procedural Analgosedation in Children
This study analyzes the analgesic efficacy and adverse events of nitrous oxide 70% combined with basic analgetics compared to nitrous oxide 70% with fentanyl intranasal for analgosedation for short and painful procedures in…
- Conditions
- Inhalation of Nitrous Oxide, Opioid Analgesic Adverse Reaction, Pain
- Trial name
- NCT02533908
- Testing
- Fentanyl intranasal, NaCl 0.9% intranasal
- Where
- Switzerland
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Hand-Foot Syndrome
Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome
Hand foot skin reaction (HFS) from capecitabine is one of the most common adverse events from capecitabine. Urea cream has been proved its benefit to prevent HFS from sorafenib.
- Trial name
- NCT05348278
- Testing
- Urea cream
- Where
- Thailand
- Volunteers
- 214 people
- Sponsor
- Mahidol University
Human Papillomavirus Vaccines, Efficacy, Self
A Multicenter Cohort Study Assessing the Efficacy and Adverse Effects of HPV Vaccination in Chinese Women
Human papillomavirus (HPV) is currently one of the most common sexually transmitted infections, according to its carcinogenicity is divided into high-risk genotypes and low-risk genotypes, research has confirmed that carcinogenic…
- Conditions
- Human Papillomavirus Vaccines, Efficacy, Self, Adverse Effect, China
- Trial name
- NCT05932576
- Where
- 5 sites in China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Fujian Maternity and Child Health Hospital
Flumazenil Adverse Reaction, Remimazolam
Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam
Remimazolam is a medication that has the advantage of a short half-life and reversibility with flumazenil. In clinical situations, the use of flumazenil for the reversal of sedation is common, but there is no precise indication…
- Conditions
- Flumazenil Adverse Reaction, Remimazolam, Hip Joint, Elderly Patients
- Trial name
- NCT05939674
- Testing
- Flumazenil, normal saline
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Pusan National University Yangsan Hospital
Pneumonia, Ventilator-Associated, Colistin Adverse Reaction
Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates
This study is planned to compare the clinical efficacy and safety of aerosolized plus intravenous colistin vs. intravenous colistin as adjunctive therapy for the treatment of ventilator-associated pneumonia (VAP) due to…
- Conditions
- Pneumonia, Ventilator-Associated, Colistin Adverse Reaction, Infection Due to Multidrug Resistant Acinetobacter, Infection Resistant to Multiple Drugs
- Trial name
- NCT02806141
- Testing
- Aerosolized plus intravenous colistin, Intravenous colistin
- Where
- Thailand
- Volunteers
- 204 people
- Sponsor
- Hat Yai Medical Education Center
Hand-foot Syndrome
Effectiveness Allopurinol Topical Agent Prevention Capecitabine-induced Hand-foot Syndrome
Hand-foot syndrome (HFS) is a dose-limiting toxicity of capecitabine for which no effective preventative treatment has been definitively demonstrated.
- Trial name
- NCT01609166
- Testing
- Allopurinol
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Testicular Cancer, Survivorship
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
- Conditions
- Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease
- Trial name
- NCT05611307
- Testing
- Lipid profile, Coronary artery assessment, Hormone levels for hypogonadism
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Drug-induced Liver Injury, Autoimmune Hepatitis
Discrimination of DILI and AIH by Artificial Intelligence
A retrospective, multi-center, non-interventional cohort study has been going to explore whether artificial intelligence can discriminate Drug-induced liver injury and Autoimmune hepatitis.
- Trial name
- NCT05532345
- Where
- China
- Volunteers
- 2,583 people
- Sponsor
- Beijing Friendship Hospital
Adverse Reaction to Diagnostic Agents and Kits Nos
Tracking Peripheral Blood Mononuclear Cells With Fluorine MRI
Cell-based therapies in the form of stem cell-based or immune cell-based therapies are becoming important treatment options that are either approved for clinical use or are showing promise in clinical trials.
- Trial name
- TRACK (NCT02921373)
- Testing
- 19F Cell Sense-labeled PBMC, MRI
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gregory A. Dekaban
Renal Adverse Events - Contrast Induced Nephropathy (CIN), Non-renal Adverse Events
Adverse Reactions to MR and CT-examinations (Enhanced and Unenhanced)
Rationale: Contrast agents are important tools for MR/CT- examinations, when it comes to diagnosing diseases. But despite their frequent use in Denmark, they are not free of serious and potentially fatal adverse reactions.
- Trial name
- NCT01132339
- Where
- Denmark
- Volunteers
- 1,467 people
- Sponsor
- Copenhagen University Hospital at Herlev
Cardiotoxicity, Elderly
Cardiotoxicity in the Elderly
CARTIER (Cardiotoxicity in the elderly) is a prospective cohort study of newly diagnosed elderly cancer patients equal or greater than 65 years of age conduced in one tertiary center (Hospital Universitario de Salamanca at Spain.
- Conditions
- Cardiotoxicity, Elderly, Cardiac Magnetic Resonance
- Trial name
- CARTIER (NCT03981588)
- Testing
- Imaging studies
- Where
- 2 sites in Spain
- Volunteers
- 110 people
- Sponsor
- AORTICA Group
VAS and JOA Scores, Adverse Reaction Rates
Combined Therapy for Cervical Disc Herniation
This study mainly explores the efficacy and safety of low-temperature plasma radiofrequency ablation combined with ozone injection and collagenase in the treatment of cervical disc herniation.The primary outcomes included the…
- Conditions
- VAS and JOA Scores, Adverse Reaction Rates, Clinical Efficacy at 1 Month and 6 Months
- Trial name
- NCT06995066
- Testing
- collagenase injection into the epidural space
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Nanchong Central Hospital
Adverse Drug Effect, Drug Effect
Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals
Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals
- Conditions
- Adverse Drug Effect, Drug Effect, Heart Arrhythmia
- Trial name
- MePhaCard (NCT04254731)
- Testing
- Same individuals treated with racemic methadone and switched to levomethadone (R-methadone)
- Where
- 3 sites in Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
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