Clinical trials: Adverse Reaction
Uterine Fibroid, Myoma;Uterus
INTERVENTION WITH TRANEXAMIC ACID TO REDUCE HAEMORRHAGE DURING LAPAROSCOPIC MYOMECTOMY
This research is planned as a randomised double-blind controlled trial. interventions to reduce haemorrhage during laparoscopic myomectomy for fiboids is important.
- Conditions
- Uterine Fibroid, Myoma;Uterus, Tranexamic Acid Adverse Reaction
- Trial name
- NCT04192643
- Testing
- Tranexamic Acid 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alkü Alanya Education and Research Hospital
Cardiac Toxicity, Lung Cancer Stage III
COr Loco-regional Advanced Lung Cancer Treated With Chemo-radiotherapy (COLA)
Patients with loco-regional NSCLC planned for curative treatment with chemoradiotherapy will be invited to participate in a prospective study; besides routine treatment, the patients will be followed with an ECG and cardiac MR…
- Conditions
- Cardiac Toxicity, Lung Cancer Stage III, Lung Cancer Stage II, Radiation Toxicity
- Trial name
- COLA (NCT05258448)
- Testing
- Chemoradiotherapy
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Hernia, Anesthetics Adverse Reaction
Local or Regional or General Anesthesia for Hernia Repair: a Randomized Controlled Trial
This present randomized trial is designed to evaluate the postoperative pain,inflammatory marker, postoperative analgesic medication, length of hospital stay and the modifications of inflammatory mediators in patients undergoing…
- Conditions
- Hernia, Anesthetics Adverse Reaction, Inflammation
- Trial name
- NCT01845376
- Testing
- local anesthesia group, spinal anesthesia group, general anesthesia group
- Where
- Thailand
- Volunteers
- 54 people
- Sponsor
- Mingkwan Wongyingsinn, MD
Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced
Granulocyte Colony Stimulating Factor for for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer
This study aims to analyze the effects of long-acting versus short-acting granulocyte colony stimulating factor (G-CSF) on the prevention febrile neutropenia (FN) in epithelial ovarian cancer patients.
- Conditions
- Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced, Epithelial Ovarian Cancer, Colony Stimulating Factors Adverse Reaction
- Trial name
- NCT04101760
- Testing
- Long-acting granulocyte colony stimulating factor, Short-acting granulocyte colony stimulating factor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Lei Li
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Diagnosis and Physiopathology of Insulin Allergy
Insulin allergy (IA) is still observed even with recombinant human insulin and insulin analogs. Obviously, the usual attitude facing an allergy, i. e.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Hypersensitivity, Immediate Hypersensitivity
- Trial name
- Allerdiab (NCT01407640)
- Testing
- Allergy tests
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy, Neuropathy
HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions
Cutaneous adverse drug reactions (cADRs) include mild maculopapular exanthema (MPE) and severe cutaneous reactions such as hypersensitivity syndrome, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN).
- Conditions
- Epilepsy, Neuropathy, Psychiatric Illness, Blepharospasm
- Trial name
- NCT03184597
- Testing
- HLA screening before commencing aromatic AEDs
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Breast Cancer
CHEmotherapy and Cognitive Deterioration in Patients With Operable Breast Cancer: Impact of Cognitive Rehabilitation (CHEMOFOG)
An interventional, non-pharmacological, monocentric study evaluating the effectiveness of cognitive rehabilitation in counteracting chemotherapy-induced cognitive impairment (CRCI) in women with operable breast cancer treated…
- Trial name
- CHEMOFOG (NCT06435559)
- Testing
- Neurotablet® and Neuropsychological evaluations, Neuropsychological evaluations
- Volunteers
- 128 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Intraoperative Floppy Iris Syndrome, Cataract
Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome
Intraoperative Floppy Iris Syndrome (IFIS) is a potentially serious cataract surgery complication. IFIS is most commonly associated with the chronic use of tamsulosin and other alpha1-adrenergic receptor antagonists prescribed in…
- Conditions
- Intraoperative Floppy Iris Syndrome, Cataract, Age-related Cataract, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT06266962
- Testing
- 1% Atropine drops, Epinephrine
- Where
- Czechia
- Volunteers
- 164 people
- Sponsor
- University Hospital Olomouc
Drug Toxicity
GHB Poisoning and Poisoning Induced by Others
Patients with suspected GHB poisoning presenting to Oslo Accident and Emergency Outpatient Clinic (Oslo Legevakt) or a hospital in Oslo (Oslo University Hospital Ullevål, Diakonhjemmet, Lovisenberg) will be included.
- Trial name
- NCT03651778
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Odd Martin Vallersnes
Cancer, Immune-related Adverse Event
Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors
The goal of this prospective, multicentre study is to investigate short- and long-term cardiovascular effects in cancer patients treated with immune checkpoint inhibitors (ICIs).
- Conditions
- Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis
- Trial name
- CAVACI (NCT05699915)
- Testing
- Cardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
- Where
- 4 sites in Belgium
- Volunteers
- 105 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Internal Medicine
Polypharmacy Among Internal Medicine Patients
The World Health Organisation Patient Safety Challenge: Medication Without Harm has brought our attention to the importance of medication-related harm as a global public health issue.
- Trial name
- NCT05756400
- Where
- Iceland
- Volunteers
- 85,942 people
- Sponsor
- University of Iceland
Breast Neoplasms, Cardiotoxicity
The Safety Management of Cardiac Toxicity in Breast Cancer Patients Under Multidiscipline Therapy.
This trial is to explore the optimal strategies for guaranteeing the cardiac safety of breast cancer patients following adjuvant radiotherapy in the modern era of multidisciplinary treatment.
- Trial name
- NCT02942615
- Testing
- limit heart dose
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Ruijin Hospital
Myotoxicity
CPK Levels After LC and Association With Analgesic Modalities
Regional anesthesia and analgesia technics are widely and securely used during general surgery procedures. Interfascial plane blocks are the latest used ones for analgesia.
- Trial name
- NCT06508177
- Testing
- İnterfascial plane block, Standart analgesia plan
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Samsun University
Medication Adherence, Medication Nonadherence
Collaborative Nurse-pharmacist Counseling for Self-administered Biologics
The goal of this clinical trial is to learn if nurse-pharmacist counseling can improve patient knowledge and confidence and prevent side effects in patients who start a biologic medication in-office and later continue the…
- Conditions
- Medication Adherence, Medication Nonadherence, Adverse Drug Event
- Trial name
- COLLAB (NCT05798104)
- Testing
- Collaborative nurse-pharmacist counseling
- Where
- United States
- Sponsor
- Tonia Carr
Polypharmacy, Gabapentin
Deprescription of Gabapentinoids in Medical Inpatients
In this trial, investigators will distribute educational brochures with information about the deprescription of gabapentinoids (gabapentin and pregabalin) to inpatients in five medical wards spread across two tertiary-care…
- Conditions
- Polypharmacy, Gabapentin, Pregabalin
- Trial name
- GABA-WHY (NCT04855578)
- Testing
- In-Hopsital Patient Educational Brochure, Physician Education about Gabapentinoid Prescription
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Breast Cancer, Drug-Related Side Effects
Gut Microbiota and Diarrhea in Breast Cancer Patients Receiving Pyrotinib
Background: Pyrotinib is an effective targeted drug for HER2-positive breast cancer, but it very frequently causes diarrhea, which can be severe enough to disrupt treatment and reduce patients' quality of life.
- Conditions
- Breast Cancer, Drug-Related Side Effects, Diarrhea
- Trial name
- NCT07264985
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome
Study to Evaluate the Use of Palifermin to Treat Toxic Epidermal Necrolysis
To test the ability of palifermin (a recombinant human keratinocyte growth factor) to decrease mucocutaneous injury and to promote epithelial repair in Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome-Toxic Epidermal…
- Trial name
- NCT02037347
- Testing
- Palifermin
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Brett King
Adverse Effect of Unspecified General Anesthetics
Effect of Coughing on Oxygenation in the Post Anaesthetic Care Unit
General anaesthesia causes small areas of lung to collapse (referred to as atelectasis) and many strategies are used to prevent or reverse this, but these strategies only temporarily improve lung function and do not persist into…
- Trial name
- NCT01314287
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- NHS Research and Development
Cardiovascular Risk Factor, Cardiovascular Diseases
The DEtermining Statin Intolerance FOr Rosuvastatin (DESIFOR) Trial
This study will enroll patients who previously were not able to tolerate being on a statin medication due to muscle-related side effects.
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Adverse Effect
- Trial name
- DESIFOR (NCT03889314)
- Testing
- Rosuvastatin 20mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Minneapolis Heart Institute Foundation
Adverse Drug Reaction
Prevention of Adverse Drug Events (ADEs) in Hospitalised Older Patients
The next four decades will see a marked expansion of the elderly population in Ireland, in particular people aged over 80 yrs. Persons aged over 80 are the highest consumers of prescription medicines in Ireland and have the…
- Trial name
- NCT01467050
- Testing
- Application of STOPP/START criteria, Normal pharmaceutical care
- Where
- Ireland
- Volunteers
- 732 people
- Sponsor
- University College Cork
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