Clinical trials: Adverse Reaction
Cardiotoxicity
Vascular Cardiotoxicity of Ponatinib
Pre-clinical studies suggest that the third generation tyrosine kinase inhibitor ponatinib can result in microvascular angiopathy and acceleration of atherosclerosis.
- Trial name
- NCT03930394
- Testing
- Contrast ultrasound perfusion imaging
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Oregon Health and Science University
Contraception
A Prospective Observational Study of the Clinical Performance of Femplant in Pakistan
This will be a non-comparative prospective observational study of women using Femplant as a primary method of contraception in Pakistan.
- Trial name
- NCT01463254
- Where
- Pakistan
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- FHI 360
Gonad Regulating Hormone Adverse Reaction, Analgesic Adverse Reaction
The Copenhagen Analgesic Study
Fundamental aspects of reproductive function are established in fetal life and there is a present increased awareness of the potential effects of fetal exposures on reproductive health of offspring.
- Trial name
- COPANA (NCT04369222)
- Testing
- Observational
- Where
- 2 sites in Denmark
- Volunteers
- 685 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Adverse Effect of Oral Contraceptives, Subsequent Encounter
The Effect of Oral Contraceptive Pills On Eyes
The investigators aimed to evaluate the effect of oral contraceptive pills(OCP) on macula, retinal nerve fiber layer and choroid thickness by using Optical Coherence Tomography (OCT).
- Trial name
- NCT02841202
- Testing
- oral contraceptive pills
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Urinary Tract Infections
Diagnosis, Antibiotic Prescribing Practices and Outcomes of cUTI in an Outpatient Setting
This prospective, multicenter, comparative cohort observational study is to determine if Guidance® UTI pathway compared to traditional diagnostic pathways reduces the rates of empiric antibiotic therapy, adverse events, and…
- Trial name
- NCT05091931
- Where
- 2 sites in United States
- Volunteers
- 3,308 people
- Sponsor
- Pathnostics
Left Ventricular Dysfunction, Heart Failure
Cardiovascular Assessment of Pediatric Cancer Survivors
The goal of this observational study is to evaluate cardiac and vascular health status of pediatric cancer survivors.
- Trial name
- CASPER (NCT05939089)
- Testing
- ECG, Echocardiography, cTnI, NT-ProBNP
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University
General Anesthetic Drug Adverse Reaction
PKPD of Rocuronium and Sugammadex Profile in Pediatric Patients
The aim of the study is to assess the pharmacokinetic and pharmacodynamic properties of rocuronium and sugammadex and their clinical effect in the terms of both the relaxation of paralysed muscles (rocuronium) and the reversal of…
- Trial name
- NCT04851574
- Testing
- Sugammadex Injection
- Where
- Poland
- Volunteers
- 37 people
- Sponsor
- Poznan University of Medical Sciences
Liver Transplant Rejection, Immunosuppressant Adverse Reaction
Long-term Benefit of MPA in Liver Transplantation
MPA drugs are antiproliferative immunosuppressants and are widely used in solid organ transplantation. MPA drugs do not affect the recipient's kidney function and do not cause metabolic abnormalities and other problems.
- Trial name
- NCT05707520
- Testing
- enteric-coated mycophenolate (MPAs), None MPA
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease
Efficacy of Phentolamine in Prevention of Contrast-Associated Acute Kidney Injury After Complex PCI
To evaluate the efficacy and safety of phentolamine in prevention of CA-AKI following complex PCI in patients at high risk of CA-AKI.
- Conditions
- CA-AKI - Contrast-Associated Acute Kidney Injury, Coronary Artery Disease, Acute Coronary Syndrome, Adrenergic Receptor Antagonist Adverse Reaction
- Trial name
- NCT06286059
- Testing
- Phentolamine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Helwan University
Diabetic Complication, Covid19 Virus Infection
Suspicion of Hypoglycemic Effect of mRNA Based Covid-19 Vaccines (Polyethylene Glycol) Will Happen , Observational Study on Diabetic Patients at Saudia Arabia
vaccines for covid-19 are gold strategy and great achievement at this century for protection against complications of covid-19 , development of many vaccines with different technology represent a big challenge for this disease so…
- Conditions
- Diabetic Complication, Covid19 Virus Infection, Hypoglycemia, Polyethylene Glycol Adverse Reaction
- Trial name
- NCT05087225
- Testing
- polyethelyene glycol
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Drug-Related Side Effects and Adverse Reactions
Different Chemotherapy Protocols Combined With Intensity Modulated Radiation Therapy in Patients With Locally Advanced Nasopharyngeal Carcinoma
This study was to evaluate the efficacy ,toxic reaction and safety of different chemotherapy combined with radiotherapy on patients with locally advanced nasopharyngeal carcinoma.
- Trial name
- NCT03177174
- Testing
- Cisplatin, Docetaxel
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Luo yanrong
Colon Cancer
Herbal Treatment to Improve Chemotherapy Delivery
This study is designed to:(1) determine the efficacy of Traditional Chinese Medicine (TCM) 'Tonifying Spleen and Kidney Sequential Regimen' (TSKSR) in improving the completion rate of 8-cycle CapeOX chemotherapy in patients with…
- Trial name
- HATCHED (NCT03716518)
- Testing
- Tonifying Spleen and Kidney Sequential Regimen
- Where
- 12 sites in China
- Volunteers
- 400 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Cancer, Drug Induced Liver Injury
Remaxol® in Patients With Drug-induced Liver Injuries During Cancer Chemotherapy
Cancer has moved from the tenth place to the second one over the last 100 years, being inferior to only cardiovascular diseases in morbidity and mortality.
- Trial name
- NCT05789797
- Testing
- Remaxol
- Where
- 5 sites in Russia
- Volunteers
- 368 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Obesity, Dapagliflozin Adverse Reaction
The Effect of Dapagliflozin on Weight Loss in Obese Adults Without Diabetes
The goal of this clinical trial is to examine the effectiveness of a drug named dapagliflozin (tested drug) on weight loss in young adults aged between 18 and 40 years with obesity who are not diagnosed with diabetes.
- Conditions
- Obesity, Dapagliflozin Adverse Reaction, Weight Loss, Effect of Drug
- Trial name
- DAPA-ANDO (NCT06000462)
- Testing
- Dapagliflozin 10mg Tab, Metformin 1000 mg (ttd)
- Where
- Oman
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oman Ministry of Health
Adverse Effect
Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
The purpose of this study is to investigate the potency between prophylactic norepinephrine and phenylephrine boluses for postspinal anesthesia hypotension in patients undergoing caesarean section.
- Trial name
- NCT05035888
- Testing
- Phenylephrine, Norepinephrine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia; Adverse Effect, Biliary Tract Diseases
Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP
Intravenous anesthesia has been widely used in endoscopic retrograde cholangiopancreatography (ERCP). In the past decade, many practices have been carried out under the propofol-based monitored anesthesia care without…
- Trial name
- NCT06015074
- Testing
- Propofol, Ciprofol
- Where
- China
- Volunteers
- 136 people
- Sponsor
- RenJi Hospital
Adverse Drug Reaction
PREemptive Pharmacogenomic Testing for Preventing Adverse Drug REactions
PREPARE is an international, prospective, multi-center, open, randomized, cross-over implementation study assessing the impact of pre-emptive pharmacogenomic testing, of a panel of actionable pharmacogenomic variants, on adverse…
- Trial name
- PREPARE (NCT03093818)
- Testing
- Pharmacogenomic testing
- Where
- 7 sites in Austria, Greece and 5 more
- Volunteers
- 6,950 people
- Sponsor
- J.J.Swen
Breast Cancer, Chemotherapy-Related Cognitive Impairment
Behavior Change Wheel-Based Music Listening for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients
Breast cancer patients frequently experience chemotherapy-related cognitive impairment (CRCI), which can negatively affect memory, attention, executive function, daily activities, and quality of life.
- Trial name
- BCW-MUSIC (NCT07641114)
- Testing
- BCW-Based Music Listening Intervention, Routine Nursing Care
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Toxic Epidermal Necrolysis, Immunotherapy
New Therapeutic Target for Toxic Epidermal Necrolysis (TEN) Using Anti-CD38+ Monoclonal Antibodies.
Toxic Epidermal Necrolysis (TEN) are rare diseases that are dermatologic emergencies characterized by widespread epidermal necrosis and sloughing of skin. A hundred patients are affected each year in France.
- Conditions
- Toxic Epidermal Necrolysis, Immunotherapy, Cutaneous Adverse Drug Reactions (CADR)
- Trial name
- NET-CD38 (NCT07110662)
- Testing
- DARATUMUMAB (DARZALEX®)
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Hospices Civils de Lyon
Safety, Vaccine Reaction
Phase-I Study to Evaluate the Safety and Immunogenicity of a Prophylactic pDNA Vaccine Candidate Against COVID-19 in Healthy Adults
A pneumonia of unknown cause detected in Wuhan, China, was first reported in December 2019. On 08 January 2020, the pathogen causing this outbreak was identified as a novel coronavirus 2019.
- Conditions
- Safety, Vaccine Reaction, Vaccine Adverse Reaction, Immunization; Infection
- Trial name
- NCT05171946
- Testing
- S.opt.FL COVID-19 pDNA vaccine
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Iman Almansour
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