Clinical trials: Adverse Reaction
Capecitabine
The Therapeutic Effect of Different Doses of Capecitabine
To observe the clinical efficacy and adverse reactions of capecitabine in the treatment of advanced colon cancer. A total of 150 patients with advanced colon cancer were selected by convenience sampling and then were divided into…
- Trial name
- NCT06246461
- Testing
- capecitabine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jingjiang People's Hospital
Cardiotoxicity
Remote Ischaemic Preconditioning in Childhood Cancer
Survival rates of children with cancers have improved significantly in the recent few decades. Nonetheless, the side effect of this class of drugs on heart function remains to be an issue of concern.
- Trial name
- NCT03166813
- Testing
- Remote Ischaemic Preconditioning, Control
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- The University of Hong Kong
Acute Pain Due to Trauma, Analgesia
Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial
Fentanyl and esketamine are both standard of care for treatment of acute severe traumatic pain in the prehospital setting in the Netherlands. However, it is not known whether they are equally effective and safe.
- Conditions
- Acute Pain Due to Trauma, Analgesia, Fentanyl, Esketamine
- Trial name
- FORE-PAIN (NCT06051227)
- Testing
- Fentanyl Citrate, Esketamine
- Where
- Netherlands
- Volunteers
- 235 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mechanical Ventilation Complication, Arterial Thrombosis
Pragmatic Randomized Trial for Arterial Catheters in the Critical Care Environment
Investigators will conduct a pragmatic randomized trial to investigate the non-inferiority of restricted use of invasive arterial lines compared to standard arterial line use.
- Conditions
- Mechanical Ventilation Complication, Arterial Thrombosis, Limb Ischemia, Shock
- Trial name
- GRACE (NCT05411315)
- Testing
- Restricted-use of arterial catheter, Standard-use of arterial catheter
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Drug Toxicity
Role of N-Acetylcysteine for Prevention of Cisplatin-induced Nephrotoxicity
Cisplatin is one of the first-line drugs used against many malignancies, such as lung cancer, head and neck cancer, esophageal cancer, gastric cancer, colorectal cancer, urothelial cancer, bladder cancer and testicular cancer.
- Trial name
- NCT06019520
- Testing
- N-Acetylcysteine, Chemotherapy
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Foundation University Islamabad
Catheter-Related Infections, Citrate Adverse Reaction
DuraLock-C Catheter Lock Solution
To evaluate the safety and performance of DuraLock-C 4.0%, 30.0%, and 46.7% for the maintenance of central venous catheter (CVC) patency in adult hemodialysis (HD) patients
- Trial name
- NCT04787926
- Testing
- Locking Solution
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Medical Components, Inc dba MedComp
Drug Toxicity
GHB Poisoning and Poisoning Induced by Others
Patients with suspected GHB poisoning presenting to Oslo Accident and Emergency Outpatient Clinic (Oslo Legevakt) or a hospital in Oslo (Oslo University Hospital Ullevål, Diakonhjemmet, Lovisenberg) will be included.
- Trial name
- NCT03651778
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Odd Martin Vallersnes
Cardiac Complication, Vascular Diseases
Evaluation of Reporting of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor Inhibitors Associated Cardiovascular Adverse reactioN.
Antiangiogenics (AAs) which are vascular endothelial growth factor (VEGF) or VEGF receptor (VEGFR) inhibitors might have high grade adverse events (AEs) on the cardio-vascular system.
- Trial name
- VEGAN (NCT03413176)
- Testing
- Cardiac complication induced by VEGF/VEGFR inhibitor
- Where
- France
- Volunteers
- 150,000 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
X-ray Contrast Media Adverse Reaction
Preparative Fasting Before Contrast-enhanced Computed Tomography
The study aims to determine whether there is a need for preparative fasting prior to contrast-enhanced computed tomography (CT).
- Trial name
- NCT03533348
- Where
- Israel
- Volunteers
- 2,148 people
- Sponsor
- HaEmek Medical Center, Israel
Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy
Circulating Tumor Cell Genome in Peripheral Blood From Hepatocellular Carcinoma Patients Under Radiotherapy
Hepatocellular carcinoma (HCC) is a common cause of cancer mortality in Asia. Most patients were presented with advanced disease.
- Conditions
- Circulating Neoplastic Cells, Adverse Effect of Radiation Therapy, Fatal Outcome
- Trial name
- NCT02066974
- Testing
- hepatoma requiring radiotherapy
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- China Medical University, China
CVI - Common Variable Immunodeficiency
A Study to Evaluate the Benefit of RUCONEST® in Subjects Who Experience ADRs Related to IVIG Infusions
Patients receiving intravenous immunoglobulin (IVIG) therapy for primary immunodeficiency and neurologic conditions may experience adverse drug reactions (ADRs). The mechanism of the ADR is unknown.
- Trial name
- NCT03576469
- Testing
- C1-esterase inhibitor [recombinant] (C1-INH-R)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- IMMUNOe Research Centers
Liver Fibrosis, Steatohepatitis
Liver Fibrosis in HIV-Infected Patients With Elevated Liver Enzymes on Antiretroviral Therapy
This study will provide a basis for research on the impact of liver injury caused by antiretroviral therapy in HIV-infected patients.
- Conditions
- Liver Fibrosis, Steatohepatitis, Elevated Transaminases
- Trial name
- NCT00326482
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine to Prevent Side Effects in Patients Who Are Receiving Chemotherapy and Radiation Therapy for Limited-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Drugs such as amifostine may protect normal cells from the side effects of chemotherapy and radiation…
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Radiation Toxicity
- Trial name
- NCT00003583
- Testing
- amifostine trihydrate, cisplatin, etoposide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Breast Cancer
Acute Exercise Cardioprotection From Doxorubicin
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury.
- Trial name
- NCT02006979
- Testing
- exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Adverse Reaction to Vaccine, COVID19 Vaccine
COVID-19 Vaccines Safety Tracking (CoVaST)
This project aims to monitor the side effects of COVID-19 vaccines worldwide actively. The primary objectives of the project include a) to estimate the prevalence of each local and systemic side effect of each COVID-19 vaccine…
- Trial name
- NCT04834869
- Testing
- BNT162b2, mRNA-1273, AZD1222
- Where
- 14 sites in United States, Canada and 12 more
- Volunteers
- 30,000 people
- Sponsor
- Masaryk University
Bladder Cancer, Drug/Agent Toxicity by Tissue/Organ
Gemcitabine, Cisplatin, and Amifostine Following Surgery in Treating Patients With Locally Advanced Bladder Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Trial name
- NCT00006105
- Testing
- amifostine trihydrate, cisplatin, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Chicago
Breast Cancer, Heart Failure
Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity
The purpose of this study is to evaluate if carvedilol can prevent the cardiotoxicity after chemotherapy in breast cancer.
- Conditions
- Breast Cancer, Heart Failure, Cardiotoxicity
- Trial name
- Ceccy (NCT01724450)
- Testing
- Carvedilol
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Corneal Toxicity, Ototoxicity
A Comparison of Infection Rates Between Two Surgical Sites
Does the use of chlorhexidine scrub prior to cutaneous surgery on the face increase the chances of toxicity to the eyes or ears? In addition, does the us eof chlorhexidine scrub on the face prior to cutaneous surgery decrease the…
- Conditions
- Corneal Toxicity, Ototoxicity, Surgical Site Infection
- Trial name
- NCT01263262
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Antifungal Drug Adverse Reaction
An Open-label Study to Evaluate the Effects of Concurrent Administration of Vaginal Antimycotic Medication Miconazole Nitrate on the Pharmacokinetics of Nestorone and Ethinyl Estradiol Delivered by a Contraceptive Vaginal Ring in Normal Ovulating Women
To evaluate the pharmacokinetics (PK) of EE and NES released from the CVR in the presence of a single dose and multiple doses of antimycotic co-medication (miconazole nitrate suppository or cream).
- Trial name
- NCT02215395
- Testing
- NES/EE CVR
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Population Council
Methanol Poisoning, Toxic Optic Neuropathy
Therapy of Toxic Optic Neuropathy Via Combination of Stem Cells With Electromagnetic Stimulation
The axons of the retinal ganglion cells combine to form the optic nerve. The optic nerve transmits electrical signals to the visual cortex by various synapses.
- Conditions
- Methanol Poisoning, Toxic Optic Neuropathy, Stem Cell Tyrosine Kinase 1 Y842X, Magnetic Field Exposure
- Trial name
- Magnovision (NCT04877067)
- Testing
- Wharton jelly derived mesenchymal stem cell, Repetitive electromagnetic stimulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Ankara Universitesi Teknokent
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