Clinical trials: Adverse Reaction
Medication Administered in Error, Medication Adverse Effects
Identifying Drug-related Problems at ED Triage (DRP-EDiT) V1
Up to a third of patients who visit emergency departments (EDs) do so because they have an issue with medicines prescribed by their doctor or purchased over the counter.
- Conditions
- Medication Administered in Error, Medication Adverse Effects, Medication Reaction
- Trial name
- DRP-EDiT (NCT05476705)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Acute Liver Failure, Acute Liver Injury, Drug Induced
miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial
The clinical trial will assess the safety of miroliverELAP for the treatment of acute liver failure, severe acute alcohol-associated hepatitis, or acute on chronic liver failure.
- Conditions
- Acute Liver Failure, Acute Liver Injury, Drug Induced, Acute on Chronic Liver Failure (ACLF), Acute Alcoholic Hepatitis
- Trial name
- NCT06285253
- Testing
- miroliverELAP treatment
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Miromatrix Medical Inc.
Cardiotoxicity, Heart Failure
Observational Trial of Cardiotoxicity in Patients Undergoing Chemotherapy.
Advances in treatment have led to improved survival of patients with cancer, but have also increased morbidity and mortality due to cancer treatment side effects.
- Conditions
- Cardiotoxicity, Heart Failure, Dilated Cardiomyopathy
- Trial name
- PROMETEY (NCT04055636)
- Testing
- Echocardiography with speckle tracking analysis., 48-hour ECG monitoring., Blood samples analysis.
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Moscow State University of Medicine and Dentistry
Anesthesia; Adverse Effect, Newborn Morbidity
Does the Mode of Anesthesia Affect the Feto-maternal Outcome in Category-1 Caesarean Section
Spinal anesthesia (SA) has become the standard technique in elective cesarean section (CS) as it results in less maternal and neonatal morbidity than general anesthesia (GA) (Grade-A recommendation, NICE).
- Trial name
- NCT04634981
- Testing
- anesthesia of emergency cesarean section
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Benha University
Cardiac Toxicity, Early-stage Breast Cancer
Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted
This study proposes that the addition of statins reduces the treatment delays or early discontinuations secondary to cardiotoxicity in patients with Stage I-III HER2 positive breast being treated with anti-HER2 therapy.
- Trial name
- NCT05559164
- Testing
- Lipitor 40mg Tablet
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Cisplatin Adverse Reaction
Comparative Study of Different Doses of Magnesium as a Protective Agent in Nephrotoxicity in Cancer Patients
The goal of this [ type of study: intervential study is to compare between different doses of magnesium to prevent cisplatin induced nephrotoxicity.] In 75 participant population with head and neck cancer recieved cisplatin it…
- Trial name
- NCT05586009
- Testing
- cisplatin with hydration magnesium, cisplatin 40 mg/m²
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy
Comparison of Three Different Sitting Positions for Performing Combined Spinal-Epidural Anesthesia
In this prospective and randomized study, we aimed to compare the effect of of three sitting positions (the traditional sitting position (TSP), the harmstring stretch position (HSP), and the squatting position on the success rate…
- Conditions
- Anesthesia; Adverse Effect, Spinal and Epidural, Hip Arthropathy, Knee Arthropathy
- Trial name
- NCT03541798
- Testing
- positions of patients for combined spinal-epidural anesthesia, Combined spinal epidural anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Lactation Suppressed, Cabergoline Adverse Reaction
Factors and Outcomes Associated With Postpartum Cabergoline Use
Cabergoline is frequently being requested by many postpartum women with a live newborn to suppress lactation. The aim of the study is to investigate which women desire such an intervention, and what side effects they are…
- Conditions
- Lactation Suppressed, Cabergoline Adverse Reaction, Postpartum DVT, Postpartum Depression
- Trial name
- NCT03965572
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
Toxicity, Drug, Adverse Drug Event
TIL and Anti-PD1 in Metastatic Melanoma
The ACTME study is an investigator initiated, single center phase I/II clinical trial for patients with progressive unresectable stage III or stage IV melanoma.
- Conditions
- Toxicity, Drug, Adverse Drug Event, Effects of Immunotherapy
- Trial name
- ACTME (NCT03638375)
- Testing
- Nivolumab & Tumor Infiltrating Lymphocytes with/without Interferon-Alpha
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Leiden University
Adverse Drug Effect, Phenylephrine
Clinical Determinants and Adverse Reactions to Tropicamide/Phenylephrine in Hospitalized Patients.
To evaluate the association between clinical determinants and the occurrence of adverse drug reactions in hospitalized patients who received tropicamide/phenylephrine 8 mg/50 mg/mL.
- Conditions
- Adverse Drug Effect, Phenylephrine, Hypertension, Cardiovascular Complication
- Trial name
- RAM-TF-IOCV (NCT07178600)
- Testing
- Ophthalmic administration of tropicamide/phenylephrine 8 mg/50 mg/mL.
- Where
- Mexico
- Volunteers
- 1,000 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Breast Cancer
Myocet Plus Endoxan for Older Patients With Breast Cancer
This study will evaluate the efficacy, safety and effect on quality of life of liposomal-encapsulated doxorubicin in combination with cyclophosphamide as first or second line treatment of older patients (≥ 70 years old) with…
- Trial name
- NCT01120171
- Testing
- Cyclophosphamide, Liposomal-encapsulated doxorubicin
- Where
- 11 sites in Greece
- Volunteers
- 64 people
- Sponsor
- Hellenic Oncology Research Group
Myopathy, HMG COA Reductase Inhibitor Adverse Reaction
Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS
It is our primary hypothesis that statin drugs impair skeletal muscle mitochondrial function and that ubiquinol (the reduced active form of CoQ10) supplementation will block impairment of PCr recovery kinetics in patients using…
- Conditions
- Myopathy, HMG COA Reductase Inhibitor Adverse Reaction, Hypercholesterolemia
- Trial name
- NCT01702987
- Testing
- ubiquinol, statin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
HMG COA Reductase Inhibitor Adverse Reaction
Muscle-Related Side Effects of Statins: Functional Impact, Mechanisms, and Potential Relief With Vitamin D Supplementation
This proposal will explore muscle function (strength and endurance) in men and women suffering from statin-induced muscle symptoms. The mechanisms responsible for these muscle symptoms will be explored.
- Trial name
- NCT01493648
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Delirium, Age-Related Cognitive Decline
Acute Care for Elders (ACE) Program at OHSU Hospital
The purpose of this investigation is to assess the effectiveness of a multi-disciplinary Acute Care for Elders (ACE) program dedicated to the care of patients age 70 and older admitted to Oregon Health \& Science University's…
- Conditions
- Delirium, Age-Related Cognitive Decline, Frail Elderly, Hospital Acquired Pressure Ulcer
- Trial name
- NCT02119078
- Testing
- Acute Care of Elders focused geriatric care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Graft vs Host Disease, Congenital Aniridia
Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation
The ARGOS-IO pressure sensor is intended to be implanted in the human eye in combination with Boston Keratoprosthesis (BKPro) surgery and to remain in place indefinitely.
- Conditions
- Graft vs Host Disease, Congenital Aniridia, Chemical Burns, Stevens-Johnson Syndrome
- Trial name
- NCT02945176
- Testing
- ARGOS-IO system
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Anesthesia; Adverse Effect, Reflex, Abnormal
The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea
The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.
- Conditions
- Anesthesia; Adverse Effect, Reflex, Abnormal, Tinnitus, Spontaneous Oto-Acoustic Emission
- Trial name
- NCT02062333
- Testing
- Dexmedetomidine, esmolol
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- TC Erciyes University
Polypharmacy, Frail Elderly Syndrome
Discontinuation of Long-term Medications in Older People Entering Nursing Home Care
Older people often have several chronic diseases requiring several medications all at once. Taking several medications all at once is called polypharmacy. Polypharmacy is common in nursing home residents.
- Conditions
- Polypharmacy, Frail Elderly Syndrome, Inappropriate Prescribing, Drug-Related Side Effects and Adverse Reactions
- Trial name
- STOPPFrail (NCT03501108)
- Testing
- STOPPFrail deprescribing criteria
- Where
- Ireland
- Volunteers
- 160 people
- Sponsor
- University College Cork
Non Small Cell Lung Cancer Metastatic, Treatment Adverse Effect
Thyroid Dysfunction and Nivolumab Reponse in NSCLC
This is an observational, retrospective and monocentric study, conducted at the university Hospital of Brest The primary objective is to assess the association between the occurrence of thyroid dysfunction in patients treated…
- Conditions
- Non Small Cell Lung Cancer Metastatic, Treatment Adverse Effect, Thyroid Dysfunction, Immune Checkpoint Inhibitor
- Trial name
- THYRONIVO (NCT04470440)
- Where
- France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Brest
Contraception
Safety,Effectiveness and Acceptability of Sino-implant II in DR
A study to assess the contraceptive effectiveness of Sino-implant (II).
- Trial name
- NCT01594632
- Testing
- Jadelle, Sino-implant (II)
- Where
- Dominican Republic
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- FHI 360
Toxicity, Drug
Neoadjuvant CRT Combined With Camrelizumab and Nimotuzumab for Initially Inoperable Patients With Esophageal Carcinoma
Neoadjuvant chemoradiotherapy followed by surgery has been the standard modality for locally advance esophageal carcinoma. According to CROSS study, the pathological complete remission rate achieved by paclitaxel and carboplatin…
- Trial name
- NCT05355168
- Testing
- neoadjuvant chemoradiotherapy combined with Camrelizumab and Nimotuzumab followed by surgery
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Anhui Provincial Hospital
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