Clinical trials: Adverse Reaction
Myocarditis, Immune Checkpoint Inhibitors
Assessment of Myocardial Injury in Patients Treated With Immune Checkpoint Inhibitors
ICI's have become the first-line treatment for patients with various malignancies. Although case studies represent fulminant myocarditis, there is uncertainty in prevalence of subclinical myocardial injury induced by ICI's.
- Conditions
- Myocarditis, Immune Checkpoint Inhibitors, Cardiotoxicity, Myocardial Injury
- Trial name
- MIICI (NCT05349058)
- Testing
- Immune Checkpoint Inhibitors
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Flinders University
Epinephrine Toxicity, Cataract
The Effect of Intracameral Carbachol and Epinephrine on Choroidal Thickness
81 eyes of 81 patients undergoing cataract surgery were included in this prospective interventional study. During cataract surgery, intracameral carbachol was applied to 27 eyes, intracameral epinephrine was administered to 20…
- Conditions
- Epinephrine Toxicity, Cataract, Carbachol Adverse Reaction, Choroid Disease
- Trial name
- NCT05225597
- Testing
- Intracameral administration of epinephrine and carbachol during cataract surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Ordu University
Metabolic Disturbance, Hyperprolactinemia
Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment
The goal of this clinical trial is to explore the potential of metformin in managing olanzapine-induced metabolic disturbance and hyperprolactinemia in patients with schizophrenia. The main questions it aims to answer are: 1.
- Conditions
- Metabolic Disturbance, Hyperprolactinemia, Schizophrenia
- Trial name
- NCT06326840
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Taipei Medical University Hospital
Local Anaesthetic Drug Adverse Reaction
Computer - Controlled Intraligamentary Local Anaesthesia In Extraction of Primary Molars
Background: Exodontia poses a psychological threat for children, increasing the need for profound local anesthesia to assure painless extraction and maintain child cooperation on the dental chair.
- Trial name
- NCT04739735
- Testing
- Dental Local Anaesthesia
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Hypertension
Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics
It is controversial whether or not patients whose Renin Angiotensin System is blocked for the treatment of hypertension suffer increased risk when undergoing surgery and anaesthesia.
- Trial name
- NCT01715584
- Testing
- Sevoflurane/oxygen/air/nitrous oxide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Contrast Media Adverse Reaction
Effects of Contrast Media Temperature on Image Quality and Clinical Adverse Events in Coronary CTA
Extrinsic prewarming of iodinated CT contrast media (CM) to body temperature reduces viscosity and injection pressures. However, guideline recommendations on the necessity to prewarm iodinated CM are conflicting.
- Trial name
- NCT05489055
- Testing
- Iopamidol
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chongqing Emergency Medical Center
Drug Hypersensitivity
Drug Provocation Test (DPT) to Paracetamol
Background : Paracetamol (acetaminophen) drug hypersensitivity reactions (DHR) are oonfirmed in about 10% of alleged cases. The diagnosis is made via an empirical drug provocation test (DPT).
- Trial name
- Paracetamol (NCT03771118)
- Where
- France
- Volunteers
- 498 people
- Sponsor
- University Hospital, Montpellier
Neuralgia, Neuropathic Pain
PK of Lidocaine/Tetracaine and PD Derived From a New Topical Formulation for Treatment of Neuropathic Pain.
Post-herpetic neuralgia (PHN) is the most frequent complications related to herpes zoster, and can persist for months or even years, and require extensive treatment.
- Conditions
- Neuralgia, Neuropathic Pain, Local Anesthetic Complication, Lidocaine Adverse Reaction
- Trial name
- PK/PDLido (NCT06171243)
- Testing
- Lidocaine topical
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Urologic Diseases, Overactive Bladder Syndrome
Trigonal vs Non Trigonal Botox Injection in OAB.
The investigators attend to conduct a prospective randomized study to assess safety and efficacy of trigonal-involved vs. trigonal-sparing botox injection technique, quality of life measurement and post-injection anticholinergics…
- Conditions
- Urologic Diseases, Overactive Bladder Syndrome, Quality of Life, Anticholinergic Syndrome
- Trial name
- NCT03533062
- Testing
- botulinum toxin A
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Vaccine Adverse Reaction
Reactogenicity, Safety and Immunogenicity of a LAIV А/17/Hong Kong/2017/75108 H7N9 Influenza Vaccine
This is a single center phase I, double-blind placebo-controlled study to assess reactogenicity, safety and immunogenicity of a live monovalent A/17/Hong Kong/2017/75108 (H7N9) influenza vaccine in healthy male and female adults…
- Trial name
- NCT03739229
- Testing
- H7N9 LAIV
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Research Institute of Influenza, Russia
Pharmacists in Geriatric Health Services, Conditions Unspecified
The Pharmacist in the Acute Geriatric Inpatient Treatment Team
This trial investigates the effects of a comprehensive pharmaceutical assessment in an acute care geriatric hospital on the number of hospital readmissions and patient's days spent at home.
- Trial name
- AGITATE (NCT03412903)
- Where
- Germany
- Volunteers
- 154 people
- Sponsor
- Prof. Dr. med. Cornelius Bollheimer
Breast Neoplasms, Neoplasm Metastasis
Study the Role of Stem Cell in Curing Drug Induced Liver Injury in Metastatic Breast Cancer (MBC)
The investigators want to know the role of Peripheral hematopoietic stem cell infusion in avoiding Drug Induced Liver Injury,and also try to research SNPs genotyping associated with Drug Induced Liver Injury.
- Trial name
- MBC (NCT01231022)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Cancer Hospital & Institute
Diabetes Mellitus, Type 2, Metformin Adverse Reaction
Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I
Metformin is associated with a high degree of gastrointestinal intolerance, which limits the effective use of the medication. It is proposed to be an inhibitor of liver mitochondrial glycerophosphate dehydrogenase which results…
- Trial name
- NCT03445702
- Testing
- Metformin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Vaccine Adverse Reaction, Gender
Anti-COVID-19 Vaccine Side Effects
In 2021 and following the COVID-19 (corona virus disease 2019) pandemic, different vaccines were initially authorized in Italy and Lebanon. Notably, vaccine side effects were poorly recorded.
- Conditions
- Vaccine Adverse Reaction, Gender, COVID-19 Vaccine Adverse Reaction
- Trial name
- VAX-IT-LEB (NCT05735769)
- Where
- Italy
- Volunteers
- 2,797 people, healthy volunteers welcome
- Sponsor
- University of Bari
Dyskinesia, Drug-Induced
Movement Disorders Caused by Antipsychotic Drugs in Older Patients
This study will assess the risk of experiencing tardive dyskinesia and other movement disturbances associated with three atypical antipsychotic drugs among middle-aged and elderly psychiatric patients.
- Trial name
- NCT00255879
- Testing
- Quetiapine, Risperidone, Olanzapine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of California, San Diego
Chemotherapeutic Toxicity, Cardiotoxicity
Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction
The investigators use the cancer registration system of National Cheng Kung University Hospital to timely screen and evaluate those patients having breast cancer or lymphoma to enroll patients to participate in this clinical…
- Conditions
- Chemotherapeutic Toxicity, Cardiotoxicity, Heart Failure, Breast Cancer
- Trial name
- NCT05892146
- Testing
- Prevention therapy, Rescue therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Cheng-Kung University Hospital
Hemodynamic Instability, Anesthesia; Adverse Effect
Heart Failure and Hemodynamic Stability During Anesthesia Induction
The study aim is to investigate whether preoperative heart failure has impact on hemodynamic stability during anesthesia induction by target controlled infusion of anesthesia (TCI) in non-cardiac, non-morbidly obese surgery.
- Conditions
- Hemodynamic Instability, Anesthesia; Adverse Effect, Heart Failure, Diastolic Dysfunction
- Trial name
- NCT03576261
- Testing
- Preoperative colloid fluid bolus (Gelofusine), Preoperative transthoracic echocardiography
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Umeå University
Terlipressin Adverse Reaction
Terlipressin Infusion in Variceal Hemorrhage
Randomized, open label study of intravenous terlipressin infusion vs. bolus for the treatment of variceal hemorrhage. 24 hour regimen consisting of intravenous terlipressin will be used either at a rate of 0.5mg/hour or 2mg bolus…
- Trial name
- TT (NCT04028505)
- Testing
- Terlipressin Injectable Product
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Aga Khan University
Amobarbital Sodium, Hemodynamics Instability
Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions
At present, there are limited data on perioperative efficacy of barbiturates at home and abroad. The purpose of this clinical trial is to observe the effects of amobarbital sodium combined with low-dose propofol on hemodynamics…
- Trial name
- NCT06385756
- Testing
- Amobarbital, Propofol
- Volunteers
- 96 people
- Sponsor
- Tongji Hospital
Schizophrenia
Genes Polymorphisms and Metabolic Effects of the Second Generation Antipsychotic Drugs in Patients With Schizophrenia
The purpose of the study is to investigate these effects of Second-Generation Antipsychotic (SGAs) on glucose and lipid metabolic parameters in patients with schizophrenia, and explore the relationship between genes polymorphisms…
- Trial name
- NCT02964923
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
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