Clinical trials: Adverse Reaction
Allergy Drug, Allergic Reaction
Preoperative Survey to Evaluate Patient Allergy
The study will only involve identification of the listed allergies from the electronic medical record and investigation into the symptoms that prompted this allergy listing.
- Conditions
- Allergy Drug, Allergic Reaction, Pediatric, Surgery
- Trial name
- NCT05670756
- Testing
- Survey
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Nationwide Children's Hospital
Agitation, Pediatric Disorder
Addition of Magnesium Sulfate to Caudal to Prevent Postoperative Emergence Agitation.
Emergence agitation after sevoflurane anesthesia is still a problem needed to be solved.The aim of the study is to delineate the effect of caudal magnesium sulfate in children undergoing lower abdominal surgery to prevent…
- Trial name
- NCT02164773
- Testing
- Magnesium Sulfate, 0.9%normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Allergic Rhinitis
Intralymphatic Immunotherapy (ILIT) for House Dust Mite, Cat, and Dog Allergen in Allergic Rhinitis Patients
We will perform double-blinded placebo-controlled randomized clinical trial which evaluates the efficacy and safety of allergen-specific intralymphatic immunotherapy (ILIT) for allergens including Dermatophagoides farinae (Df)…
- Trial name
- ILIT (NCT02269566)
- Testing
- HollisterStier, Normal saline
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Gachon University Gil Medical Center
Adverse Reaction to Antiplatelet Agent, Acute Coronary Syndrome
BLeeding Events and Maintenance DoSe of PraSugrel
Aim: to verify if after the acute phase of ACS acute coronary syndrome (1-months), from 1 to 12 months the reduction of maintenance dose of prasugrel from 10 mg to 5 mg/day may reduce the bleeding events (5 mg vs 10 mg).
- Trial name
- BLESS (NCT01790854)
- Testing
- Prasugrel dose 5 mg/day, Prasugrel dose 10 mg/day
- Where
- Italy
- Volunteers
- 195 people
- Sponsor
- David Antoniucci
Frailty, Neuromuscular Blockade
Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery
Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital…
- Conditions
- Frailty, Neuromuscular Blockade, General Anesthetic Drug Adverse Reaction, Gynecologic Cancer
- Trial name
- FIGO (NCT06216002)
- Testing
- Train of four nerve stimulator
- Where
- Thailand
- Volunteers
- 356 people
- Sponsor
- Mahidol University
Administration Related Reaction, Failed Moderate Sedation During Procedure
Intranasal Dexmedetomidine VS Oral Chloral Hydrate for Rescue Sedation During Magnetic Resonance Imaging
The purpose of this investigation was to test the hypothesis that intranasal dexmedetomidine is as effective as second dose of oral chloral hydrate for rescue sedation in infant age between 1 and 6 months who were not adequately…
- Conditions
- Administration Related Reaction, Failed Moderate Sedation During Procedure, Chloral Hydrate Adverse Reaction
- Trial name
- NCT02239445
- Testing
- chloral hydrate Group, low dose dexmedetomidine group, high dose dexmedetomidine group
- Where
- 2 sites in China
- Volunteers
- 158 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Adverse Effect of Radiation Therapy
IORT-Boost-Study, Prospective Observational Study for Intraoperative Radiotherapy of the Breast as a Boost
In this study the investigators observe the investigation, whether the new method for Boost-Irradiation with the Intrabeam Device of Zeiss Germany influences local recurrence, acute and late effects of Radiotherapy, overall…
- Trial name
- NCT02114086
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- Kantonsspital Münsterlingen
Wound Heal, Wound Surgical
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part II
The purpose of the present study is to evaluate the influence of the post-surgical chlorhexidine indication in the gene expression profile and cellular behavior in the early wound healing process -24 hours after injury- of the…
- Conditions
- Wound Heal, Wound Surgical, Oral Soft Tissue Conditions, Chlorhexidine Adverse Reaction
- Trial name
- NCT04276129
- Testing
- periodontal surgery + 24 hr buccal attached gingiva (G) biopsy, post-surgical CHX mouth-rinses indication
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- University of Roma La Sapienza
Injection Site Reaction, Injection Site Bruising
Effectiveness of Mechano-Analgesia and Cold Application on Ecchymosis, Pain and Satisfaction at Subcutaneous Heparin Injection
Fifty-five patients received three subcutaneous heparin injections (165 injections) by the same investigator using additional techniques such as mechano-analgesia and cold application, and without any additional techniques.
- Trial name
- NCT03645369
- Testing
- ShotBlocker, Ice pack
- Volunteers
- 165 people
- Sponsor
- Istanbul Saglik Bilimleri University
Drug-Induced Liver Injury
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Pill.
This is a prospective registry study to surveil early liver injuries caused by Xianlin Gubao Pill (XLGB Pill) through a non-intervention observational way.
- Trial name
- NCT03091556
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Non Small Cell Lung Cancer, Cardiotoxicity
Prospective Study on Radiation Induced Cardiotoxicity Assessed By PET-CT for Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
Prospective clinical study designed to evaluate damage to the heart after receiving standard of care chemotherapy and radiation therapy for locally advanced Non-Small Cell Lung Cancer (NSCLC).
- Conditions
- Non Small Cell Lung Cancer, Cardiotoxicity, Locally Advanced Non-Small Cell Lung Cancer, Radiation Therapy
- Trial name
- NCT07761910
- Testing
- PET/CT 18F-Flurpiridaz Rest/Stress Test, Coronary CT Angiography (CCTA), 18F-Flurpiridaz
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Postoperative Pain, Pregabalin
Pregabalin is an Effective Treatment for Acute Postoperative Pain Following Spinal Surgery Without Major Side Effects
The objective of this study is to examine the efficacy and side effect of varying dose of pregabalin for the treatment of postoperative pain after spinal surgery.
- Conditions
- Postoperative Pain, Pregabalin, Spine Surgery, Adverse Reaction to Pregabalin
- Trial name
- NCT05478382
- Testing
- Pregabalin 25 MG
- Volunteers
- 132 people
- Sponsor
- Ajou University School of Medicine
Drug Allergy, Cephalosporin Allergy
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in…
- Conditions
- Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy
- Trial name
- DACAT (NCT06406114)
- Testing
- Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Contraception, Progestogen Adverse Reaction
Does Oral Desogestrel Prior to Insertion of the Etonogestrel Subdermal Implant Improve Continuation Rate at One Year?
Objective: The etonogestrel subdermal implant (ESI) is an effective and safe method of contraception. Although highly efficient, ESI produces often side effects that reduce its tolerance and acceptance.
- Trial name
- NCT05174195
- Testing
- Desogestrel 0.075 milligram, Implanon NXT® subdermal implant
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Cardiac Toxicity, Chemotherapeutic Agent Toxicity
Aerobic Exercise in Patients Receiving Chemotherapy for Cancer
RATIONALE: Aerobic exercise may help prevent side effects caused by chemotherapy and help improve heart health. PURPOSE: This randomized clinical trial is studying the side effects of aerobic exercise and to see how well it works…
- Conditions
- Cardiac Toxicity, Chemotherapeutic Agent Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00728429
- Testing
- exercise intervention
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Maximum Tolerated Dose, GIST
Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)
This is a single-arm, two cohort, open label phase I/II clinical trial studying the combination of oral imatinib 400 mg, once daily, and oral selinexor given once weekly (Cohort A); and single-agent oral selinexor 60 mg BIW…
- Conditions
- Maximum Tolerated Dose, GIST, Metastatic Adult Soft Tissue Sarcoma, Drug Toxicity
- Trial name
- SeliGIST (NCT04138381)
- Testing
- Selinexor, Imatinib
- Where
- 6 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Grupo Espanol de Investigacion en Sarcomas
Anesthesia; Adverse Effect, Spinal and Epidural, Anaesthetic Complication Neurological
Neurotoxicity of Spinal Anesthesia With Ropivacaine and Bupivacaine
Consenting patients, scheduled for orthopaedic surgery under spinal anesthesia will be randomly assigned (1:1) to receive ropivacaine or bupivacaine as a single shot before the start of surgery, followed by bolus doses of the…
- Trial name
- BuRoNe (NCT03293472)
- Testing
- Ropivacaine, Bupivacaine
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- University of Rzeszow
Safety Surveillance, Adverse Drug Events
Post-marketing Safety Surveillance of Qizhi Tongluo Capsules:a Registry Study.
This registry aims to monitor the safety of Qizhi Tongluo Capsules and to identify the potential risk factors for its adverse drug reactions.
- Conditions
- Safety Surveillance, Adverse Drug Events, Adverse Drug Reactions, Severe Adverse Events
- Trial name
- NCT04479553
- Testing
- Qizhi Tongluo Capsules
- Where
- 14 sites in China
- Volunteers
- 30,000 people
- Sponsor
- Zhong Wang
Ovarian Cancer, Cognitive Impairment
Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT
This is a phase I, dose-escalation and phase II dose-expansion clinical trial determining the maximum tolerated dose (MTD) and safety and tolerability of adding N-Acetyl-Cysteine (NAC) to ovarian cancer patients who are receiving…
- Trial name
- NCT04520139
- Testing
- N-Acetyl-Cysteine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Irvine
Cardiotoxicity
Effect of Trimetazidine on Radiotherapy-induced Heart Damage.
This is a randomized controlled trial. 80 patients with thoracic radiotherapy will be included. Participants will be randomly divided into experimental group or control group.
- Trial name
- NCT04939857
- Testing
- Trimetazidine
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
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